Entity: Universitat Rovira i Virgili (URV)
Confidenciality: Si
Education area(s): Nutrició i Metabolisme
APS: NO
Title in different languages: Neuroinflammation, microglia, NAD+, type 1 diabetes mellitus, vitamin B3
Abstract: Diabetes mellitus is frequently linked to chronic neuroinflammation. Accumulating evidence suggest that activated microglia underlies diabetic neuropathy. Currently there are no specific treatments for diabetic neuropathy. NAD+ is a mandatory coenzyme for the action of several NAD+ consuming enzymes that are involved in the inflammatory response. Therefore, its replenishment was considered as a potential therapy to prevent neuroinflammation. In this context, nicotinamide (NAM), which is a precursor of NAD+, may have positive effects on diabetic neuroinflammation. We tested the hypothesis that increased bioavailability of NAM will attenuate activation of microglia in a mouse model of experimental diabetes mellitus type 1 (T1D)
Subject: Nicotina
Academic year: 2021-2022
Language: en
Work's public defense date: 2022-06-20
Subject areas: Health sciences
Student: Torres Mendez, Jeimy Katherine
Department: Bioquímica i Biotecnologia
Creation date in repository: 2023-07-05
Keywords: neuroinflammation, NAD+, type 1 diabetes mellitus
Title in original language: Neuroinflammation, microglia, NAD+, type 1 diabetes mellitus, vitamin B3
Access Rights: info:eu-repo/semantics/openAccess
Repositori URV