Does aging affect the immune status? A comparative analysis in 300 healthy volunteers from France, Austria and Spain

Vasson, M.P. Farges, M.C. Goncalves-Mendes, N. Talvas, J. Ribalta, J. Winklhofer-Roob, B. Rock, E. Rossary, A.

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Does aging affect the immune status? A comparative analysis in 300 healthy volunteers from France, Austria and Spain - PC:561

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https://hdl.handle.net/20.500.11797/PC561

Autor segons l'article:	Vasson, M.P. Farges, M.C. Goncalves-Mendes, N. Talvas, J. Ribalta, J. Winklhofer-Roob, B. Rock, E. Rossary, A.
Any de publicació de la revista:	2013
ISSN:	1742-4933
DOI de l'article:	10.1186/1742-4933-10-38
Enllaç font original:	http://www.immunityageing.com/content/10/1/38
Versió de l'article dipositat:	info:eu-repo/semantics/publishedVersion
Accès a la llicència d'ús:	https://creativecommons.org/licenses/by/3.0/es/
Departament:	Medicina i Cirurgia
URL Document de llicència:	https://repositori.urv.cat/ca/proteccio-de-dades/
Entitat:	Universitat Rovira i Virgili.
Pàgina inicial:	38
Pàgina final:	49
Volum de revista:	10

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Títol:	Does aging affect the immune status? A comparative analysis in 300 healthy volunteers from France, Austria and Spain
Descripció:	10.1186/1742-4933-10-38 Background As the European population is getting older, there is growing need in scientific data on how to achieve healthy and successful aging. A decline in immune function with age is unanimously supported by many epidemiological and clinical observations, with a decrease in T-cell mediated function encompassing a large part of this alteration. In the EU-funded VITAGE project, the effects of aging on biomarkers of immune status are being studied in three European countries. According to strict inclusion/exclusion criteria, a cohort of 300 healthy male non-smoking 20¿75 years old volunteers were enrolled in France (n?=?99), Spain (n?=?100) and Austria (n?=?101). In each country, the volunteers were classified as a function of age (one age group per decade). Biomarkers of immune status were determined including delayed-type hypersensitivity tests, measurement of lymphocyte surface markers, and serum determinations of interleukin-2, complement fractions and immunoglobulins. Results There were moderate differences in the biomarkers of immune status of the VITAGE study volunteers among the three European centres. The percentage of Natural Killer (NK) cells was 156% and 142% higher in Spain as compared to France and Austria, respectively (p?
Cobertura:	Anglès
Tipus:	Article info:eu-repo/semantics/publishedVersion
Coautor:	Medicina i Cirurgia Universitat Rovira i Virgili.
Matèria:	1742-4933
Idioma:	Austria and Spain
Autor:	Vasson, M.P. Farges, M.C. Goncalves-Mendes, N. Talvas, J. Ribalta, J. Winklhofer-Roob, B. Rock, E. Rossary, A.
Drets:	info:eu-repo/semantics/openAccess
Data:	2013

TÍTOL:

https://hdl.handle.net/20.500.11797/PC561

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