Does aging affect the immune status? A comparative analysis in 300 healthy volunteers from France, Austria and Spain

Vasson, M.P. Farges, M.C. Goncalves-Mendes, N. Talvas, J. Ribalta, J. Winklhofer-Roob, B. Rock, E. Rossary, A.

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Does aging affect the immune status? A comparative analysis in 300 healthy volunteers from France, Austria and Spain - PC:561

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https://hdl.handle.net/20.500.11797/PC561

Autor según el artículo:	Vasson, M.P. Farges, M.C. Goncalves-Mendes, N. Talvas, J. Ribalta, J. Winklhofer-Roob, B. Rock, E. Rossary, A.
Año de publicación de la revista:	2013
ISSN:	1742-4933
DOI del artículo:	10.1186/1742-4933-10-38
Enlace a la fuente original:	http://www.immunityageing.com/content/10/1/38
Versión del articulo depositado:	info:eu-repo/semantics/publishedVersion
Acceso a la licencia de uso:	https://creativecommons.org/licenses/by/3.0/es/
Departamento:	Medicina i Cirurgia
URL Documento de licencia:	https://repositori.urv.cat/ca/proteccio-de-dades/
Entidad:	Universitat Rovira i Virgili.
Página inicial:	38
Página final:	49
Volumen de revista:	10

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Título:	Does aging affect the immune status? A comparative analysis in 300 healthy volunteers from France, Austria and Spain
Descripción:	10.1186/1742-4933-10-38 Background As the European population is getting older, there is growing need in scientific data on how to achieve healthy and successful aging. A decline in immune function with age is unanimously supported by many epidemiological and clinical observations, with a decrease in T-cell mediated function encompassing a large part of this alteration. In the EU-funded VITAGE project, the effects of aging on biomarkers of immune status are being studied in three European countries. According to strict inclusion/exclusion criteria, a cohort of 300 healthy male non-smoking 20¿75 years old volunteers were enrolled in France (n?=?99), Spain (n?=?100) and Austria (n?=?101). In each country, the volunteers were classified as a function of age (one age group per decade). Biomarkers of immune status were determined including delayed-type hypersensitivity tests, measurement of lymphocyte surface markers, and serum determinations of interleukin-2, complement fractions and immunoglobulins. Results There were moderate differences in the biomarkers of immune status of the VITAGE study volunteers among the three European centres. The percentage of Natural Killer (NK) cells was 156% and 142% higher in Spain as compared to France and Austria, respectively (p?
Cobertura:	Anglès
Tipo:	Article info:eu-repo/semantics/publishedVersion
Coautor:	Medicina i Cirurgia Universitat Rovira i Virgili.
Materia:	1742-4933
Idioma:	Austria and Spain
Autor:	Vasson, M.P. Farges, M.C. Goncalves-Mendes, N. Talvas, J. Ribalta, J. Winklhofer-Roob, B. Rock, E. Rossary, A.
Derechos:	info:eu-repo/semantics/openAccess
Fecha:	2013

TÍTULO:

https://hdl.handle.net/20.500.11797/PC561

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