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Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia - imarina:9207263

Autor/s de la URV:Bodi Saera, Maria Amparo / Correig Fraga, Eudald / Gómez Alvarez, Josep / Rodríguez Oviedo, Alejandro Hugo / TREFLER CRESPO, SANDRA INES
Autor segons l'article:Moreno, Gerard; Rodriguez, Alejandro; Sole-Violan, Jordi; Martin-Loeches, Ignacio; Diaz, Emili; Bodi, Maria; Reyes, Luis F.; Gomez, Josep; Guardiola, Juan; Trefler, Sandra; Vidaur, Loreto; Papiol, Elisabet; Socias, Lorenzo; Garcia-Vidal, Carolina; Correig, Eudald; Marin-Corral, Judith; Restrepo, Marcos, I; Nguyen-Van-Tam, Jonathan S.; Torres, Antoni;GETGAG Working Grp
Adreça de correu electrònic de l'autor:eudald.correig@urv.cat
josep.gomez@urv.cat
eudald.correig@urv.cat
alejandrohugo.rodriguez@urv.cat
mariaamparo.bodi@urv.cat
mariaamparo.bodi@urv.cat
Identificador de l'autor:0000-0002-0573-7621
0000-0001-8828-5984
0000-0001-7652-8379
0000-0001-7652-8379
Any de publicació de la revista:2021
Tipus de publicació:Journal Publications
Referència de l'ítem segons les normes APA:Moreno, Gerard; Rodriguez, Alejandro; Sole-Violan, Jordi; Martin-Loeches, Ignacio; Diaz, Emili; Bodi, Maria; Reyes, Luis F.; Gomez, Josep; Guardiola, (2021). Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia. Erj Open Research, 7(1), 00888-2020. DOI: 10.1183/23120541.00888-2020
Referència a l'article segons font original:Erj Open Research. 7 (1): 00888-2020
Resum:Background: The relationship between early oseltamivir treatment (within 48 h of symptom onset) and mortality in patients admitted to intensive care units (ICUs) with severe influenza is disputed. This study aimed to investigate the association between early oseltamivir treatment and ICU mortality in critically ill patients with influenza pneumonia. Methods: This was an observational study of patients with influenza pneumonia admitted to 184 ICUs in Spain during 2009-2018. The primary outcome was to evaluate the association between early oseltamivir treatment and ICU mortality compared with later treatment. Secondary outcomes were to compare the duration of mechanical ventilation and ICU length of stay between the early and later oseltamivir treatment groups. To reduce biases related to observational studies, propensity score matching and a competing risk analysis were performed. Results: During the study period, 2124 patients met the inclusion criteria. All patients had influenza pneumonia and received oseltamivir before ICU admission. Of these, 529 (24.9%) received early oseltamivir treatment. In the multivariate analysis, early treatment was associated with reduced ICU mortality (OR 0.69, 95% CI 0.51-0.95). After propensity score matching, early oseltamivir treatment was associated with improved survival rates in the Cox regression (hazard ratio 0.77, 95% CI 0.61-0.99) and competing risk (subdistribution hazard ratio 0.67, 95% CI 0.53-0.85) analyses. The ICU length of stay and duration of mechanical ventilation were shorter in patients receiving early treatment. Conclusions: Early oseltamivir treatment is associated with improved survival rates in critically ill patients with influenza pneumonia, and may decrease ICU length of stay and mechanical ventilation duration.
DOI de l'article:10.1183/23120541.00888-2020
Enllaç font original:https://openres.ersjournals.com/content/7/1/00888-2020.abstract
Versió de l'article dipositat:info:eu-repo/semantics/publishedVersion
Accès a la llicència d'ús:https://creativecommons.org/licenses/by/3.0/es/
Departament:Bioquímica i Biotecnologia
URL Document de llicència:https://repositori.urv.cat/ca/proteccio-de-dades/
Àrees temàtiques:Respiratory system
Pulmonary and respiratory medicine
Paraules clau:Good health and well-being
Entitat:Universitat Rovira i Virgili
Data d'alta del registre:2024-11-23
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