Autor/es de la URV: | Bodi Saera, Maria Amparo / Correig Fraga, Eudald / Gómez Alvarez, Josep / Rodríguez Oviedo, Alejandro Hugo / TREFLER CRESPO, SANDRA INES |
Autor según el artículo: | Moreno, Gerard; Rodriguez, Alejandro; Sole-Violan, Jordi; Martin-Loeches, Ignacio; Diaz, Emili; Bodi, Maria; Reyes, Luis F.; Gomez, Josep; Guardiola, Juan; Trefler, Sandra; Vidaur, Loreto; Papiol, Elisabet; Socias, Lorenzo; Garcia-Vidal, Carolina; Correig, Eudald; Marin-Corral, Judith; Restrepo, Marcos, I; Nguyen-Van-Tam, Jonathan S.; Torres, Antoni;GETGAG Working Grp |
Direcció de correo del autor: | eudald.correig@urv.cat josep.gomez@urv.cat eudald.correig@urv.cat alejandrohugo.rodriguez@urv.cat mariaamparo.bodi@urv.cat mariaamparo.bodi@urv.cat |
Identificador del autor: | 0000-0002-0573-7621 0000-0001-8828-5984 0000-0001-7652-8379 0000-0001-7652-8379 |
Año de publicación de la revista: | 2021 |
Tipo de publicación: | Journal Publications |
Referencia de l'ítem segons les normes APA: | Moreno, Gerard; Rodriguez, Alejandro; Sole-Violan, Jordi; Martin-Loeches, Ignacio; Diaz, Emili; Bodi, Maria; Reyes, Luis F.; Gomez, Josep; Guardiola, (2021). Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia. Erj Open Research, 7(1), 00888-2020. DOI: 10.1183/23120541.00888-2020 |
Referencia al articulo segun fuente origial: | Erj Open Research. 7 (1): 00888-2020 |
Resumen: | Background: The relationship between early oseltamivir treatment (within 48 h of symptom onset) and mortality in patients admitted to intensive care units (ICUs) with severe influenza is disputed. This study aimed to investigate the association between early oseltamivir treatment and ICU mortality in critically ill patients with influenza pneumonia.
Methods: This was an observational study of patients with influenza pneumonia admitted to 184 ICUs in Spain during 2009-2018. The primary outcome was to evaluate the association between early oseltamivir treatment and ICU mortality compared with later treatment. Secondary outcomes were to compare the duration of mechanical ventilation and ICU length of stay between the early and later oseltamivir treatment groups. To reduce biases related to observational studies, propensity score matching and a competing risk analysis were performed.
Results: During the study period, 2124 patients met the inclusion criteria. All patients had influenza pneumonia and received oseltamivir before ICU admission. Of these, 529 (24.9%) received early oseltamivir treatment. In the multivariate analysis, early treatment was associated with reduced ICU mortality (OR 0.69, 95% CI 0.51-0.95). After propensity score matching, early oseltamivir treatment was associated with improved survival rates in the Cox regression (hazard ratio 0.77, 95% CI 0.61-0.99) and competing risk (subdistribution hazard ratio 0.67, 95% CI 0.53-0.85) analyses. The ICU length of stay and duration of mechanical ventilation were shorter in patients receiving early treatment.
Conclusions: Early oseltamivir treatment is associated with improved survival rates in critically ill patients with influenza pneumonia, and may decrease ICU length of stay and mechanical ventilation duration. |
DOI del artículo: | 10.1183/23120541.00888-2020 |
Enlace a la fuente original: | https://openres.ersjournals.com/content/7/1/00888-2020.abstract |
Versión del articulo depositado: | info:eu-repo/semantics/publishedVersion |
Acceso a la licencia de uso: | https://creativecommons.org/licenses/by/3.0/es/ |
Departamento: | Bioquímica i Biotecnologia |
URL Documento de licencia: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
Áreas temáticas: | Respiratory system Pulmonary and respiratory medicine |
Palabras clave: | Good health and well-being |
Entidad: | Universitat Rovira i Virgili |
Fecha de alta del registro: | 2024-11-23 |
Descripción: | Background: The relationship between early oseltamivir treatment (within 48 h of symptom onset) and mortality in patients admitted to intensive care units (ICUs) with severe influenza is disputed. This study aimed to investigate the association between early oseltamivir treatment and ICU mortality in critically ill patients with influenza pneumonia.
Methods: This was an observational study of patients with influenza pneumonia admitted to 184 ICUs in Spain during 2009-2018. The primary outcome was to evaluate the association between early oseltamivir treatment and ICU mortality compared with later treatment. Secondary outcomes were to compare the duration of mechanical ventilation and ICU length of stay between the early and later oseltamivir treatment groups. To reduce biases related to observational studies, propensity score matching and a competing risk analysis were performed.
Results: During the study period, 2124 patients met the inclusion criteria. All patients had influenza pneumonia and received oseltamivir before ICU admission. Of these, 529 (24.9%) received early oseltamivir treatment. In the multivariate analysis, early treatment was associated with reduced ICU mortality (OR 0.69, 95% CI 0.51-0.95). After propensity score matching, early oseltamivir treatment was associated with improved survival rates in the Cox regression (hazard ratio 0.77, 95% CI 0.61-0.99) and competing risk (subdistribution hazard ratio 0.67, 95% CI 0.53-0.85) analyses. The ICU length of stay and duration of mechanical ventilation were shorter in patients receiving early treatment.
Conclusions: Early oseltamivir treatment is associated with improved survival rates in critically ill patients with influenza pneumonia, and may decrease ICU length of stay and mechanical ventilation duration |
Tipo: | Journal Publications |
Coautor: | Universitat Rovira i Virgili |
Títol: | Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia |
Materia: | Pulmonary and Respiratory Medicine,Respiratory System Good health and well-being Respiratory system Pulmonary and respiratory medicine |
Fecha: | 2021 |
Autor: | Moreno, Gerard Rodriguez, Alejandro Sole-Violan, Jordi Martin-Loeches, Ignacio Diaz, Emili Bodi, Maria Reyes, Luis F. Gomez, Josep Guardiola, Juan Trefler, Sandra Vidaur, Loreto Papiol, Elisabet Socias, Lorenzo Garcia-Vidal, Carolina Correig, Eudald Marin-Corral, Judith Restrepo, Marcos, I Nguyen-Van-Tam, Jonathan S. Torres, Antoni GETGAG Working Grp |
Derechos: | info:eu-repo/semantics/openAccess |
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