Repositori institucional URV
| URV's Author/s: | Alonso Perez, Maria Yolanda / Martorell Bonet, Lourdes / Miralles Ibiza, Maria Carmen / Muntané Medina, Gerard / Sánchez Gistau, Vanessa / Valiente Pallejà, Alba / Vilella Cuadrada, Elisabet |
| Author, as appears in the article.: | Alonso, Yolanda; Miralles, Carmen; Algora, M Jose; Valiente-Palleja, Alba; Sanchez-Gistau, Vanessa; Muntane, Gerard; Labad, Javier; Vilella, Elisabet; Martorell, Lourdes |
| Author's mail: | alba.valiente@urv.cat gerard.muntane@urv.cat vanessa.sanchezg@urv.cat lourdes.martorell@urv.cat elisabet.vilella@urv.cat mariayolanda.alonso@urv.cat mariacarmen.miralles@estudiants.urv.cat |
| Author identifier: | 0000-0003-4999-2197 0000-0002-1887-5919 0000-0001-9784-0636 |
| Journal publication year: | 2022 |
| Publication Type: | Journal Publications |
| APA: | Alonso, Yolanda; Miralles, Carmen; Algora, M Jose; Valiente-Palleja, Alba; Sanchez-Gistau, Vanessa; Muntane, Gerard; Labad, Javier; Vilella, Elisabet; (2022). Risk factors for metabolic syndrome in individuals with recent-onset psychosis at disease onset and after 1-year follow-up. Scientific Reports, 12(1), 11386-. DOI: 10.1038/s41598-022-15479-x |
| Paper original source: | Scientific Reports. 12 (1): 11386- |
| Abstract: | Metabolic syndrome (MetS) is a cluster of parameters encompassing the most dangerous heart attack risk factors, associated with increased morbidity and mortality. It is highly prevalent in recent-onset psychosis (ROP) patients. In this pilot study, we evaluated MetS parameters (fasting glucose, high-density lipoprotein (HDL) cholesterol (HDL-c), fasting triglycerides, waist circumference, and systolic and diastolic blood pressure), clinical symptoms, pharmacological treatment, lifestyle, and inflammatory markers in 69 patients with ROP and 61 healthy controls (HCs). At baseline, waist circumference (p = 0.005) and fasting triglycerides (p = 0.007) were higher in patients with ROP than in HCs. At the 1-year follow-up, patients showed clinical improvement, with a reduction in the positive and negative syndrome scale (PANSS) score (p < 0.001), dietary intake (p = 0.001), and antipsychotic medication dose (p < 0.001); however, fasting glucose (p = 0.011), HDL-c (p = 0.013) and waist circumference worsened (p < 0.001). We identified sex, age, BMI, dietary intake, physical activity, daily tobacco use, daily cannabis use, and antipsychotic doses as risk factors contributing to baseline MetS parameters. After 1-year follow-up, those factors plus the PANSS and Calgary Depression Scale for Schizophrenia (CDSS) scores were associated with MetS parameters. Further studies are needed to understand the contributions of the studied risk factors in patients with ROP at onset and during disease progression. |
| Article's DOI: | 10.1038/s41598-022-15479-x |
| Paper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Medicina i Cirurgia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física |
| Keywords: | Triglycerides Risk factors Psychotic disorders Pilot projects Metabolic syndrome Humans Glucose Follow-up studies Cholesterol, hdl Antipsychotic agents 1st-episode schizophrenia-patients validation spectrum disorders spanish version sex prevalence physical-activity mental states cardiovascular risk cardiometabolic risk |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2025-02-18 |
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