Risk factors for metabolic syndrome in individuals with recent-onset psychosis at disease onset and after 1-year follow-up

Alonso, Yolanda; Miralles, Carmen; Algora, M Jose; Valiente-Palleja, Alba; Sanchez-Gistau, Vanessa; Muntane, Gerard; Labad, Javier; Vilella, Elisabet; Martorell, Lourdes

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Risk factors for metabolic syndrome in individuals with recent-onset psychosis at disease onset and after 1-year follow-up - imarina:9271524

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https://hdl.handle.net/20.500.11797/imarina9271524

Autor/es de la URV:	Alonso Perez, Maria Yolanda / Martorell Bonet, Lourdes / Miralles Ibiza, Maria Carmen / Muntané Medina, Gerard / Sánchez Gistau, Vanessa / Valiente Pallejà, Alba / Vilella Cuadrada, Elisabet
Autor según el artículo:	Alonso, Yolanda; Miralles, Carmen; Algora, M Jose; Valiente-Palleja, Alba; Sanchez-Gistau, Vanessa; Muntane, Gerard; Labad, Javier; Vilella, Elisabet; Martorell, Lourdes
Direcció de correo del autor:	alba.valiente@urv.cat gerard.muntane@urv.cat vanessa.sanchezg@urv.cat lourdes.martorell@urv.cat elisabet.vilella@urv.cat mariayolanda.alonso@urv.cat mariacarmen.miralles@estudiants.urv.cat
Identificador del autor:	0000-0003-4999-2197 0000-0002-1887-5919 0000-0001-9784-0636
Año de publicación de la revista:	2022
Tipo de publicación:	Journal Publications
Referencia de l'ítem segons les normes APA:	Alonso, Yolanda; Miralles, Carmen; Algora, M Jose; Valiente-Palleja, Alba; Sanchez-Gistau, Vanessa; Muntane, Gerard; Labad, Javier; Vilella, Elisabet; (2022). Risk factors for metabolic syndrome in individuals with recent-onset psychosis at disease onset and after 1-year follow-up. Scientific Reports, 12(1), 11386-. DOI: 10.1038/s41598-022-15479-x
Referencia al articulo segun fuente origial:	Scientific Reports. 12 (1): 11386-
Resumen:	Metabolic syndrome (MetS) is a cluster of parameters encompassing the most dangerous heart attack risk factors, associated with increased morbidity and mortality. It is highly prevalent in recent-onset psychosis (ROP) patients. In this pilot study, we evaluated MetS parameters (fasting glucose, high-density lipoprotein (HDL) cholesterol (HDL-c), fasting triglycerides, waist circumference, and systolic and diastolic blood pressure), clinical symptoms, pharmacological treatment, lifestyle, and inflammatory markers in 69 patients with ROP and 61 healthy controls (HCs). At baseline, waist circumference (p = 0.005) and fasting triglycerides (p = 0.007) were higher in patients with ROP than in HCs. At the 1-year follow-up, patients showed clinical improvement, with a reduction in the positive and negative syndrome scale (PANSS) score (p < 0.001), dietary intake (p = 0.001), and antipsychotic medication dose (p < 0.001); however, fasting glucose (p = 0.011), HDL-c (p = 0.013) and waist circumference worsened (p < 0.001). We identified sex, age, BMI, dietary intake, physical activity, daily tobacco use, daily cannabis use, and antipsychotic doses as risk factors contributing to baseline MetS parameters. After 1-year follow-up, those factors plus the PANSS and Calgary Depression Scale for Schizophrenia (CDSS) scores were associated with MetS parameters. Further studies are needed to understand the contributions of the studied risk factors in patients with ROP at onset and during disease progression.
DOI del artículo:	10.1038/s41598-022-15479-x
Versión del articulo depositado:	info:eu-repo/semantics/publishedVersion
Acceso a la licencia de uso:	https://creativecommons.org/licenses/by/3.0/es/
Departamento:	Medicina i Cirurgia
URL Documento de licencia:	https://repositori.urv.cat/ca/proteccio-de-dades/
Áreas temáticas:	Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
Palabras clave:	Triglycerides Risk factors Psychotic disorders Pilot projects Metabolic syndrome Humans Glucose Follow-up studies Cholesterol, hdl Antipsychotic agents 1st-episode schizophrenia-patients validation spectrum disorders spanish version sex prevalence physical-activity mental states cardiovascular risk cardiometabolic risk
Entidad:	Universitat Rovira i Virgili
Fecha de alta del registro:	2025-02-18

Descripción:	Metabolic syndrome (MetS) is a cluster of parameters encompassing the most dangerous heart attack risk factors, associated with increased morbidity and mortality. It is highly prevalent in recent-onset psychosis (ROP) patients. In this pilot study, we evaluated MetS parameters (fasting glucose, high-density lipoprotein (HDL) cholesterol (HDL-c), fasting triglycerides, waist circumference, and systolic and diastolic blood pressure), clinical symptoms, pharmacological treatment, lifestyle, and inflammatory markers in 69 patients with ROP and 61 healthy controls (HCs). At baseline, waist circumference (p = 0.005) and fasting triglycerides (p = 0.007) were higher in patients with ROP than in HCs. At the 1-year follow-up, patients showed clinical improvement, with a reduction in the positive and negative syndrome scale (PANSS) score (p < 0.001), dietary intake (p = 0.001), and antipsychotic medication dose (p < 0.001); however, fasting glucose (p = 0.011), HDL-c (p = 0.013) and waist circumference worsened (p < 0.001). We identified sex, age, BMI, dietary intake, physical activity, daily tobacco use, daily cannabis use, and antipsychotic doses as risk factors contributing to baseline MetS parameters. After 1-year follow-up, those factors plus the PANSS and Calgary Depression Scale for Schizophrenia (CDSS) scores were associated with MetS parameters. Further studies are needed to understand the contributions of the studied risk factors in patients with ROP at onset and during disease progression.
Tipo:	Journal Publications
Títol:	Risk factors for metabolic syndrome in individuals with recent-onset psychosis at disease onset and after 1-year follow-up
Coautor:	Universitat Rovira i Virgili
Materia:	Multidisciplinary,Multidisciplinary Sciences Triglycerides Risk factors Psychotic disorders Pilot projects Metabolic syndrome Humans Glucose Follow-up studies Cholesterol, hdl Antipsychotic agents 1st-episode schizophrenia-patients validation spectrum disorders spanish version sex prevalence physical-activity mental states cardiovascular risk cardiometabolic risk Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
Autor:	Alonso, Yolanda Miralles, Carmen Algora, M Jose Valiente-Palleja, Alba Sanchez-Gistau, Vanessa Muntane, Gerard Labad, Javier Vilella, Elisabet Martorell, Lourdes
Derechos:	info:eu-repo/semantics/openAccess
Fecha:	2022

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