Repositori institucional URV
| Autor/s de la URV: | Nabgan, Walid |
| Autor segons l'article: | Shahzadi I; Islam M; Saeed H; Haider A; Shahzadi A; Haider J; Ahmed N; Ul-Hamid A; Nabgan W; Ikram M; Rathore HA |
| Adreça de correu electrònic de l'autor: | walid.nabgan@urv.cat |
| Identificador de l'autor: | 0000-0001-9901-862X |
| Any de publicació de la revista: | 2022 |
| Tipus de publicació: | Journal Publications |
| Referència de l'ítem segons les normes APA: | Shahzadi I; Islam M; Saeed H; Haider A; Shahzadi A; Haider J; Ahmed N; Ul-Hamid A; Nabgan W; Ikram M; Rathore HA (2022). Formation of biocompatible MgO/cellulose grafted hydrogel for efficient bactericidal and controlled release of doxorubicin. International Journal Of Biological Macromolecules, 220(), 1277-1286. DOI: 10.1016/j.ijbiomac.2022.08.142 |
| Referència a l'article segons font original: | International Journal Of Biological Macromolecules. 220 1277-1286 |
| Resum: | In this study, MgO-doped CNC-g-PAA hydrogel was synthesized by grafting poly (acrylic acid) (PAA) onto cellulose nanocrystals (CNC) and then doped Magnesium oxide (MgO) using pH 7.0 and 12.0 to obtain an efficient nanocomposite hydrogel for antibacterial and anti-cancer activities. The synthesized nanocomposite hydrogels were evaluated by detailed characterization and confirmed the formation of a well-interconnected porous structure. MgO/CNC-g-PAA (pH = 12.0) exhibited improved bactericidal tendencies towards gram-negative and gram-positive bacteria, which was further investigated by in-silico molecular docking analyses and also examined the reactive oxygen species production by photocatalysis and free radical-scavenging assay. After this, Doxorubicin (DOX), a model anticancer drug, was successfully loaded into nanocomposites (∼79 %) by electrostatic interaction and confirmed pH-triggered based release, which was over 53.7 % in 24 h. Finally, in vitro cytotoxicity-based analysis confirmed the improved antitumor efficacy of nanocomposite hydrogels. These findings revealed that MgO/CNC-g-PAA hydrogels might be prospective carriers for controlled drug delivery. |
| DOI de l'article: | 10.1016/j.ijbiomac.2022.08.142 |
| Enllaç font original: | https://www.sciencedirect.com/science/article/abs/pii/S0141813022018451?via%3Dihub |
| Versió de l'article dipositat: | info:eu-repo/semantics/publishedVersion |
| Accès a la llicència d'ús: | https://creativecommons.org/licenses/by/3.0/es/ |
| Departament: | Enginyeria Química |
| URL Document de llicència: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Àrees temàtiques: | Zootecnia / recursos pesqueiros Structural biology Química Polymer science Planejamento urbano e regional / demografia Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General energy Food science Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Energy (miscellaneous) Economics and econometrics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, applied Biotecnología Biomaterials Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física |
| Paraules clau: | Poly (acrylic acid) (paa) Hydrogel Drug-delivery Cellulose nanocrystals (cnc) therapy polymer poly (acrylic acid) (paa) particles mgo nanoparticles hydrogel cellulose nanocrystals antibacterial |
| Entitat: | Universitat Rovira i Virgili |
| Data d'alta del registre: | 2024-09-07 |
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| DocumentPrincipal | DocumentPrincipal | application/pdf |
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