Articles producció científica> Psicologia

Age-related effects of X-ray irradiation on mouse hippocampus

  • Dades identificatives

    Identificador: PC:1653
    Autors:
    Montserrat BellésArianna CasciatiKatalin DobosFrancesca AntonelliAnett BenedekStefan J. KempfAndrea BaloghMirella TanoriLuis HerediaMichael J. AtkinsonChristine von ToerneOmid AzimzadehAnna SaranGeza SáfrányMohammed A. BenotmaneM. Victoria Linares-VidalSoile TapioKatalin LumniczkySimonetta Pazzaglia
    Resum:
    DOI: 10.18632/oncotarget.8575URL: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=8575
  • Altres:

    Autor segons l'article: Montserrat Bellés; Arianna Casciati; Katalin Dobos; Francesca Antonelli; Anett Benedek; Stefan J. Kempf; Andrea Balogh; Mirella Tanori; Luis Heredia; Michael J. Atkinson; Christine von Toerne; Omid Azimzadeh; Anna Saran; Geza Sáfrány; Mohammed A. Benotmane; M. Victoria Linares-Vidal; Soile Tapio; Katalin Lumniczky; Simonetta Pazzaglia
    Departament: Psicologia Ciències Mèdiques Bàsiques
    Autor/s de la URV: BELLES MATEU, MONTSERRAT; Arianna Casciati; Katalin Dobos; Francesca Antonelli; Anett Benedek; Stefan J. Kempf; Andrea Balogh; Mirella Tanori; HEREDIA SANTAELLA, LUIS; Michael J. Atkinson; Christine von Toerne; Omid Azimzadeh; Anna Saran; Geza Sáfrány; Mohammed A. Benotmane; LINARES VIDAL, M. VICTORIA; Soile Tapio; Katalin Lumniczky; Simonetta Pazzaglia
    Paraules clau: cognitive effects mitochondria proteomics
    Resum: Therapeutic irradiation of pediatric and adult patients can profoundly affect adult neurogenesis, and cognitive impairment manifests as a deficit in hippocampal-dependent functions. Age plays a major role in susceptibility to radiation, and younger children are at higher risk of cognitive decay when compared to adults. Cranial irradiation affects hippocampal neurogenesis by induction of DNA damage in neural progenitors, through the disruption of the neurogenic microenvironment, and defective integration of newborn neurons into the neuronal network. Our goal here was to assess cellular and molecular alterations induced by cranial X-ray exposure to low/moderate doses (0.1 and 2 Gy) in the hippocampus of mice irradiated at the postnatal ages of day 10 or week 10, as well as the dependency of these phenomena on age at irradiation. To this aim, changes in the cellular composition of the dentate gyrus, mitochondrial functionality, proteomic profile in the hippocampus, as well as cognitive performance were evaluated by a multidisciplinary approach. Our results suggest the induction of specific alterations in hippocampal neurogenesis, microvascular density and mitochondrial functions, depending on age at irradiation. A better understanding of how irradiation impairs hippocampal neurogenesis at low and moderate doses is crucial to minimize adverse effects of therapeutic irradiation, contributing also to radiation safety regulations.
    Grup de recerca: Laboratori de Toxicologia i Salut Mediambiental
    Àrees temàtiques: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1949-2553
    Identificador de l'autor: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
    Data d'alta del registre: 2016-06-09
    Pàgina final: 28058
    Volum de revista: 7
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=8575
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.18632/oncotarget.8575
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2016
    Pàgina inicial: 28040
    Tipus de publicació: Article Artículo Article
  • Paraules clau:

    Proteòmica
    Hipocamp
    Mitocondris
    cognitive effects
    mitochondria
    proteomics
    Bioquímica i biotecnologia
    Bioquímica y tecnología
    Biochemistry and technology
    1949-2553
  • Documents:

  • Cerca a google

    Search to google scholar