Articles producció científica> Bioquímica i Biotecnologia

Decrease in specific micronutrient intake in colorectal cancer patients with tumors presenting Ki-ras mutation

  • Dades identificatives

    Identificador: PC:1661
    Autors:
    JORDI SALASNURIA LASOSERGI MASM. JOSE LAFUENTEXAVIER CASTERADMANUEL TRIASANTONIO BALLESTARAFAEL MOLINACARLOS ASCASOSHICHUN ZHENGJOHN K. WIENCKEAMALIA LAFUENTE
    Resum:
    BACKGROUND: The diversity of the Mediterranean diet and the heterogeneity of acquired genetic alterations in colorectal cancer (CRC) led us to examine the possible association between dietary factors and mutations, such as Ki-ras mutations, in genes implicated in the pathogenesis of these neoplasms. PATIENTS AND METHODS: The study was based on 246 cases and 296 controls. For the molecular study only 117 patients with Ki-ras tumor expression were included. Dietary patterns were assessed using a semi-quantitative food frequency questionnaire. RESULTS: Patients with Ki-ras mutations in codon 12 (K12) consumed significantly less vitamin A (p=0.02), B1 (p=0.01), D (p=0.02) and iron (p=0.03) than controls, whereas patients without these mutations had similar intakes of these nutrients to controls. The consumption of fiber, folate, vitamin E and potassium was lower in the two subgroups of patients (K12-positive or -negative) than in controls. Mutation in codon 13 was not associated with any nutrient deficit. CONCLUSION: These results support previous findings that certain micronutrients protect against colorectal neoplasia and emphasize the importance of considering the different molecular forms of CRC as etiologically distinct diseases.
  • Altres:

    Autor segons l'article: JORDI SALAS; NURIA LASO; SERGI MAS; M. JOSE LAFUENTE; XAVIER CASTERAD; MANUEL TRIAS; ANTONIO BALLESTA; RAFAEL MOLINA; CARLOS ASCASO; SHICHUN ZHENG; JOHN K. WIENCKE; AMALIA LAFUENTE
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: SALAS SALVADÓ, JORGE; NURIA LASO; SERGI MAS; M. JOSE LAFUENTE; XAVIER CASTERAD; MANUEL TRIAS; ANTONIO BALLESTA; RAFAEL MOLINA; CARLOS ASCASO; SHICHUN ZHENG; JOHN K. WIENCKE; AMALIA LAFUENTE
    Paraules clau: Diet colorectal cancer risk Ki-ras
    Resum: BACKGROUND: The diversity of the Mediterranean diet and the heterogeneity of acquired genetic alterations in colorectal cancer (CRC) led us to examine the possible association between dietary factors and mutations, such as Ki-ras mutations, in genes implicated in the pathogenesis of these neoplasms. PATIENTS AND METHODS: The study was based on 246 cases and 296 controls. For the molecular study only 117 patients with Ki-ras tumor expression were included. Dietary patterns were assessed using a semi-quantitative food frequency questionnaire. RESULTS: Patients with Ki-ras mutations in codon 12 (K12) consumed significantly less vitamin A (p=0.02), B1 (p=0.01), D (p=0.02) and iron (p=0.03) than controls, whereas patients without these mutations had similar intakes of these nutrients to controls. The consumption of fiber, folate, vitamin E and potassium was lower in the two subgroups of patients (K12-positive or -negative) than in controls. Mutation in codon 13 was not associated with any nutrient deficit. CONCLUSION: These results support previous findings that certain micronutrients protect against colorectal neoplasia and emphasize the importance of considering the different molecular forms of CRC as etiologically distinct diseases.
    Grup de recerca: Alimentació, Nutrició, Creixement i Salut Mental
    Àrees temàtiques: Biochemistry and technology Bioquímica y tecnología Bioquímica i biotecnologia
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0250-7005
    Identificador de l'autor: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
    Data d'alta del registre: 2016-06-09
    Pàgina final: 2020
    Volum de revista: 24
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: http://ar.iiarjournals.org/content/24/3B/2011.long
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2004
    Pàgina inicial: 2011
    Tipus de publicació: Article Artículo Article
  • Paraules clau:

    Recte -- Càncer
    Còlon -- Càncer
    Dieta
    Diet
    colorectal cancer risk
    Ki-ras
    Biochemistry and technology
    Bioquímica y tecnología
    Bioquímica i biotecnologia
    0250-7005
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