Articles producció científica> Bioquímica i Biotecnologia

Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development

  • Dades identificatives

    Identificador: PC:2849
    Autors:
    Salas-Salvadó, J.Casas, R.Urpi-Sardà, M.Sacanella, E.Arranz, S.Corella, D.Castañer, O.Lamuela-Raventós, R.Lapetra, J.Portillo, M.Estruch, R.
    Resum:
    Objective. To evaluate the long-Term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex®. Results. At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1β (P<0.05; all) compared to LFD. IL-1β, IL-5, IL-7, IL-12p70, IL-18, TNF-α, IFN-γ, GCSF, GMCSF, and ENA78 (P<0.05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 (P<0.05; both) in the MeDiet+nuts group. Conclusions. Long-Term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.
  • Altres:

    Autor segons l'article: Salas-Salvadó, J.; Casas, R.; Urpi-Sardà, M.; Sacanella, E.; Arranz, S.; Corella, D.; Castañer, O.; Lamuela-Raventós, R.; Lapetra, J.; Portillo, M.; Estruch, R.
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: SALAS SALVADÓ, JORGE; Casas, R.; Urpi-Sardà, M.; Sacanella, E.; Arranz, S.; Corella, D.; Castañer, O.; Lamuela-Raventós, R.; Lapetra, J.; Portillo, M.; Estruch, R.
    Resum: Objective. To evaluate the long-Term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex®. Results. At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1β (P<0.05; all) compared to LFD. IL-1β, IL-5, IL-7, IL-12p70, IL-18, TNF-α, IFN-γ, GCSF, GMCSF, and ENA78 (P<0.05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 (P<0.05; both) in the MeDiet+nuts group. Conclusions. Long-Term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.
    Grup de recerca: Alimentació, Nutrició, Creixement i Salut Mental
    Àrees temàtiques: Biochemistry and technology Bioquímica y tecnología Bioquímica i biotecnologia
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0962-9351
    Identificador de l'autor: 0000-0003-2700-7459; ; ; ; ; ; ; ; ; ;
    Data d'alta del registre: 2017-09-14
    Volum de revista: 2017
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.hindawi.com/journals/mi/2017/3674390/
    Programa de finançament: altres; RyC; PI13/02184
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1155/2017/3674390
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2017
    Pàgina inicial: 3674390
    Tipus de publicació: Article Artículo Article
  • Paraules clau:

    Placa ateroscleròtica
    Dieta mediterrània
    Biochemistry and technology
    Bioquímica y tecnología
    Bioquímica i biotecnologia
    0962-9351
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