Articles producció científica> Ciències Mèdiques Bàsiques

Body iron status and gastric cancer risk in the EURGAST study

  • Dades identificatives

    Identificador: imarina:2006483
    Autors:
    Fonseca-Nunes A., Agudo A., Aranda N., Arija V., Cross A.J., Molina E., Sanchez M.J., Bueno-De-Mesquita H.B., Siersema P., Weiderpass E., Krogh V., Mattiello A., Tumino R., Saieva C., Naccarati A., Ohlsson B., Sjöberg K., Boutron-Ruault M.C., Cadeau C., Fagherazzi G., Boeing H., Steffen A., Kühn T., Katzke V., Tjønneland A., Olsen A., Khaw K.T., Wareham N., Key T., Lu Y., Riboli E., Peeters P.H., Gavrila D., Dorronsoro M., Quirõs J.R., Barricarte A., Jenab M., Zamora-Ros R., Freisling H., Trichopoulou A., Fonseca-Nunes A., Agudo A., Aranda N.
    Resum:
    Although it appears biologically plausible for iron to be associated with gastric carcinogenesis, the evidence is insufficient to lead to any conclusions. To further investigate the relationship between body iron status and gastric cancer risk, we conducted a nested case-control study in the multicentric European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured prediagnostic serum iron, ferritin, transferrin and C-reactive protein, and further estimated total iron-binding capacity (TIBC) and transferrin saturation (TS). Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by iron metrics were estimated from multivariable conditional logistic regression models. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and ferritin and TS indices (ORlog2 ?=?0.80, 95% CI?=?0.72-0.88; OR10%increment ?=?0.87, 95% CI?=?0.78-0.97, respectively). These associations appear to be restricted to noncardia gastric cancer (ferritin showed a p for heterogeneity?=?0.04 and TS had a p for heterogeneity?=?0.02), and no differences were found by histological type. TIBC increased risk of overall gastric cancer (OR50 µg/dl ?=?1.13, 95% CI?=?1.02-1.2) and also with noncardia gastric cancer (p for heterogeneity?=?0.04). Additional analysis suggests that time between blood draw and gastric cancer diagnosis could modify these findings. In conclusion, our results showed a decreased risk of gastric cancer related to higher body iron stores as measured by serum iron and ferritin. Further investigation is needed to clarify t
  • Altres:

    Autor segons l'article: Fonseca-Nunes A., Agudo A., Aranda N., Arija V., Cross A.J., Molina E., Sanchez M.J., Bueno-De-Mesquita H.B., Siersema P., Weiderpass E., Krogh V., Mattiello A., Tumino R., Saieva C., Naccarati A., Ohlsson B., Sjöberg K., Boutron-Ruault M.C., Cadeau C., Fagherazzi G., Boeing H., Steffen A., Kühn T., Katzke V., Tjønneland A., Olsen A., Khaw K.T., Wareham N., Key T., Lu Y., Riboli E., Peeters P.H., Gavrila D., Dorronsoro M., Quirõs J.R., Barricarte A., Jenab M., Zamora-Ros R., Freisling H., Trichopoulou A., Fonseca-Nunes A., Agudo A., Aranda N.
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: Aranda Pons, Núria / Arija Val, Maria Victoria
    Paraules clau: Nested case-control study Iron homeostasis Gastric cancer iron homeostasis gastric cancer
    Resum: Although it appears biologically plausible for iron to be associated with gastric carcinogenesis, the evidence is insufficient to lead to any conclusions. To further investigate the relationship between body iron status and gastric cancer risk, we conducted a nested case-control study in the multicentric European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured prediagnostic serum iron, ferritin, transferrin and C-reactive protein, and further estimated total iron-binding capacity (TIBC) and transferrin saturation (TS). Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by iron metrics were estimated from multivariable conditional logistic regression models. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and ferritin and TS indices (ORlog2 ?=?0.80, 95% CI?=?0.72-0.88; OR10%increment ?=?0.87, 95% CI?=?0.78-0.97, respectively). These associations appear to be restricted to noncardia gastric cancer (ferritin showed a p for heterogeneity?=?0.04 and TS had a p for heterogeneity?=?0.02), and no differences were found by histological type. TIBC increased risk of overall gastric cancer (OR50 µg/dl ?=?1.13, 95% CI?=?1.02-1.2) and also with noncardia gastric cancer (p for heterogeneity?=?0.04). Additional analysis suggests that time between blood draw and gastric cancer diagnosis could modify these findings. In conclusion, our results showed a decreased risk of gastric cancer related to higher body iron stores as measured by serum iron and ferritin. Further investigation is needed to clarify the role of iron in gastric carcinogenesis.© 2015 UICC.
    Àrees temàtiques: Saúde coletiva Química Oncology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Cancer research Biotecnología Biodiversidade
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00207136
    Adreça de correu electrònic de l'autor: nuria.aranda@urv.cat victoria.arija@urv.cat
    Identificador de l'autor: 0000-0001-9708-747X 0000-0002-1758-0975
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijc.29669
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: International Journal Of Cancer. 137 (12): 2904-2914
    Referència de l'ítem segons les normes APA: Fonseca-Nunes A., Agudo A., Aranda N., Arija V., Cross A.J., Molina E., Sanchez M.J., Bueno-De-Mesquita H.B., Siersema P., Weiderpass E., Krogh V., Ma (2015). Body iron status and gastric cancer risk in the EURGAST study. International Journal Of Cancer, 137(12), 2904-2914. DOI: 10.1002/ijc.29669
    DOI de l'article: 10.1002/ijc.29669
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2015
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Cancer Research,Oncology
    Nested case-control study
    Iron homeostasis
    Gastric cancer
    iron homeostasis
    gastric cancer
    Saúde coletiva
    Química
    Oncology
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Cancer research
    Biotecnología
    Biodiversidade
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