Repositori URV

Autor segons l'article: Sala-Vila, Aleix; Guasch-Ferre, Marta; Hu, Frank B; Sanchez-Tainta, Ana; bullo, Monica; Serra-Mir, Merce; Lopez-Sabater, Carmen; Sorli, Jose V; Aros, Fernando; Fiol, Miquel; Munoz, Miguel A; Serra-Majem, Luis; Alfredo Martinez, J; Corella, Dolores; Fito, Montserrat; Salas-Salvado, Jordi; Martinez-Gonzalez, Miguel A; Estruch, Ramon; Ros, Emilio

Departament: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia

Autor/s de la URV: Babio Sánchez, Nancy Elvira / Bulló Bonet, Mònica / Cabre Vila, Juan Jose / Díaz López, Andres / Fernández Ballart, Joan Domènech / IBARROLA JURADO, NURIA / Salas Salvadó, Jorge

Paraules clau: Sudden cardiac death Nutrition Fatty acid nutrition fatty acid

Resum: Epidemiological evidence suggests a cardioprotective role of ?-linolenic acid (ALA), a plant-derived ?-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ?-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all-cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long-chain n-3 polyunsaturated fatty acids (?500 mg/day).We longitudinally evaluated 7202 participants in the PREvención con DIeta MEDiterránea (PREDIMED) trial. Multivariable-adjusted Cox regression models were fitted to estimate hazard ratios. ALA intake correlated to walnut consumption (r=0.94). During a 5.9-y follow-up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios for meeting ALA recommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56-0.92) for all-cause mortality and 0.95 (95% CI 0.58-1.57) for fatal cardiovascular disease. The hazard ratios for meeting the recommendation for long-chain n-3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67-1.05) for all-cause mortality, 0.61 (95% CI 0.39-0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29-0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22-1.01) for sudden cardiac death. The highest reduction in all-cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45-0.87]).In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all-cause mortality, whereas protection from cardiac mortality is limited to fish-derived long-chain n-3 polyunsaturated fatty acids.URL: http://www.Controlled-trials.com/. Unique identifier: ISRCTN35739639.© 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

Àrees temàtiques: Saúde coletiva Nutrição Medicina ii Medicina i Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología

Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20479980

Adreça de correu electrònic de l'autor: juanjose.cabre@urv.cat andres.diaz@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat

Identificador de l'autor: 0000-0003-1082-6861 0000-0002-7500-5629 0000-0002-0218-7046 0000-0003-2700-7459 0000-0003-3527-5277

Data d'alta del registre: 2024-10-12

Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion

Enllaç font original: https://www.ahajournals.org/doi/10.1161/JAHA.115.002543

URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/

Referència a l'article segons font original: Journal Of The American Heart Association. 5 (1): e002543-

Referència de l'ítem segons les normes APA: Sala-Vila, Aleix; Guasch-Ferre, Marta; Hu, Frank B; Sanchez-Tainta, Ana; bullo, Monica; Serra-Mir, Merce; Lopez-Sabater, Carmen; Sorli, Jose V; Aros, (2016). Dietary alpha-Linolenic Acid, Marine omega-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvencion con DIeta MEDiterranea (PREDIMED) Study. Journal Of The American Heart Association, 5(1), e002543-. DOI: 10.1161/JAHA.115.002543

DOI de l'article: 10.1161/JAHA.115.002543

Entitat: Universitat Rovira i Virgili

Any de publicació de la revista: 2016

Tipus de publicació: Journal Publications