Autor segons l'article: Babio, Nancy; Toledo, Estefania; Estruch, Ramon; Ros, Emilio; Martinez-Gonzalez, Miguel A; Castaner, Olga; Bullo, Monica; Corella, Dolores; Aros, Fernando; Gomez-Gracia, Enrique; Ruiz-Gutierrez, Valentina; Fiol, Miquel; Lapetra, Jose; Lamuela-Raventos, Rosa M; Serra-Majem, Lluis; Pinto, Xavier; Basora, Josep; Sorli, Jose V; Salas-Salvado, Jordi
Departament: Ciències Mèdiques Bàsiques Medicina i Cirurgia Bioquímica i Biotecnologia
Autor/s de la URV: Babio Sánchez, Nancy Elvira / Basora Gallisa, Josep / Bulló Bonet, Mònica / Castro Salomó, Antoni / Fernández Ballart, Joan Domènech / Salas Salvadó, Jorge
Paraules clau: Women Weight-loss Style diet Spanish men Prevalence Population Monounsaturated fat Cardiovascular risk-factors Body-fat distribution Adherence
Resum: Little evidence exists on the effect of an energy-unrestricted healthy diet on metabolic syndrome. We evaluated the long-term effect of Mediterranean diets ad libitum on the incidence or reversion of metabolic syndrome.We performed a secondary analysis of the PREDIMED trial--a multicentre, randomized trial done between October 2003 and December 2010 that involved men and women (age 55-80 yr) at high risk for cardiovascular disease. Participants were randomly assigned to 1 of 3 dietary interventions: a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with nuts or advice on following a low-fat diet (the control group). The interventions did not include increased physical activity or weight loss as a goal. We analyzed available data from 5801 participants. We determined the effect of diet on incidence and reversion of metabolic syndrome using Cox regression analysis to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).Over 4.8 years of follow-up, metabolic syndrome developed in 960 (50.0%) of the 1919 participants who did not have the condition at baseline. The risk of developing metabolic syndrome did not differ between participants assigned to the control diet and those assigned to either of the Mediterranean diets (control v. olive oil HR 1.10, 95% CI 0.94-1.30, p = 0.231; control v. nuts HR 1.08, 95% CI 0.92-1.27, p = 0.3). Reversion occurred in 958 (28.2%) of the 3392 participants who had metabolic syndrome at baseline. Compared with the control group, participants on either Mediterranean diet were more likely to undergo reversion (control v. olive oil HR 1.35, 95% CI 1.15-1.58, p < 0.001; control v. nuts HR 1.28, 95% CI 1.08-1.51, p < 0.001). Participants in the group receiving olive oil supplementation showed significant decreases in both central obesity and high fasting glucose (p = 0.02); participants in the group supplemented with nuts showed a significant decrease in central obesity.A Mediterranean diet supplemented with either extra virgin olive oil or nuts is not associated with the onset of metabolic syndrome, but such diets are more likely to cause reversion of the condition. An energy-unrestricted Mediterranean diet may be useful in reducing the risks of central obesity and hyperglycemia in people at high risk of cardiovascular disease.ClinicalTrials.gov, no. ISRCTN35739639.© 2014 Canadian Medical Association or its licensors.
Àrees temàtiques: Saúde coletiva Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina ii Medicina i General medicine Educação física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 08203946
Adreça de correu electrònic de l'autor: josep.basora@urv.cat monica.bullo@urv.cat josep.basora@urv.cat antoni.castro@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Identificador de l'autor: 0000-0002-0218-7046 0000-0001-5441-6333 0000-0003-2700-7459 0000-0003-3527-5277
Data d'alta del registre: 2024-10-12
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.cmaj.ca/content/186/17/E649
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Canadian Medical Association Journal. 186 (17): E649-E657
Referència de l'ítem segons les normes APA: Babio, Nancy; Toledo, Estefania; Estruch, Ramon; Ros, Emilio; Martinez-Gonzalez, Miguel A; Castaner, Olga; Bullo, Monica; Corella, Dolores; Aros, Fern (2014). Mediterranean diets and metabolic syndrome status in the PREDIMED randomized trial. Canadian Medical Association Journal, 186(17), E649-E657. DOI: 10.1503/cmaj.140764
DOI de l'article: 10.1503/cmaj.140764
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2014
Tipus de publicació: Journal Publications
Repositori URV