Articles producció científica> Bioquímica i Biotecnologia

Chromium Exposure and Risk of Cardiovascular Disease in High Cardiovascular Risk Subjects - Nested Case-Control Study in the Prevention With Mediterranean Diet (PREDIMED) Study.

  • Dades identificatives

    Identificador: imarina:2975466
    Autors:
    Gutierrez-Bedmar, MarioAngel Martinez-Gonzalez, MiguelMunoz-Bravo, CarlosRuiz-Canela, MiguelMariscal, AlbertoSalas-Salvado, JordiEstruch, RamonCorella, DoloresAros, FernandoFito, MonserratLapetra, JoseSerra-Majem, LluisPinto, XavierAlonso-Gomez, AngelPortoles, OlgaFiol, MiquelBullo, MonicaCastaner, OlgaRos, EmilioGomez-Gracia, Enrique
    Resum:
    Epidemiological data on chromium (Cr) exposure and the risk of cardiovascular disease (CVD) are still limited. Toenail Cr level (TCL) provides a time-integrated measure reflecting long-term Cr exposure. We measured TCL to assess the hypothesis that long-term Cr exposure was inversely associated with incident CVD in a population at high risk for CVD.Methods?and?Results:The associations between TCL and CVD were evaluated in a case-control study nested within the "PREvención con DIeta MEDiterránea" (PREDIMED) trial. We randomly selected 147 of the 288 patients diagnosed with CVD during follow-up and matched them on age and sex to 271 controls. Instrumental neutron activation analysis was used to assess TCL. In-person interviews, medical record reviews, and validated questionnaires were used to assess covariates. The fully adjusted OR for the highest vs. lowest quartile of toenail Cr was 0.54 (95% CI: 0.26-1.14; Ptrend=0.189) for the nested case-control study. On stratification for diabetes mellitus (DM), OR was 1.37 (95% CI: 0.54-3.46; Ptrend=0.364) for the DM group, and 0.25 (95% CI: 0.08-0.80; Ptrend=0.030) for the non-DM group (P for interaction=0.078).The present findings, although not statistically significant, are consistent with previously reported inverse associations between TCL and CVD. These results, especially for non-DM patients, increase the limited epidemiological knowledge about the possible protective role of Cr against CVD. (Trial registration: www.controlled-trials.com; ISRCTN35739639.).
  • Altres:

    Autor segons l'article: Gutierrez-Bedmar, Mario; Angel Martinez-Gonzalez, Miguel; Munoz-Bravo, Carlos; Ruiz-Canela, Miguel; Mariscal, Alberto; Salas-Salvado, Jordi; Estruch, Ramon; Corella, Dolores; Aros, Fernando; Fito, Monserrat; Lapetra, Jose; Serra-Majem, Lluis; Pinto, Xavier; Alonso-Gomez, Angel; Portoles, Olga; Fiol, Miquel; Bullo, Monica; Castaner, Olga; Ros, Emilio; Gomez-Gracia, Enrique
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Bulló Bonet, Mònica / Salas Salvadó, Jorge
    Paraules clau: Toenail biomarker Predimed Diabetes Chromium Cardiovascular disease
    Resum: Epidemiological data on chromium (Cr) exposure and the risk of cardiovascular disease (CVD) are still limited. Toenail Cr level (TCL) provides a time-integrated measure reflecting long-term Cr exposure. We measured TCL to assess the hypothesis that long-term Cr exposure was inversely associated with incident CVD in a population at high risk for CVD.Methods?and?Results:The associations between TCL and CVD were evaluated in a case-control study nested within the "PREvención con DIeta MEDiterránea" (PREDIMED) trial. We randomly selected 147 of the 288 patients diagnosed with CVD during follow-up and matched them on age and sex to 271 controls. Instrumental neutron activation analysis was used to assess TCL. In-person interviews, medical record reviews, and validated questionnaires were used to assess covariates. The fully adjusted OR for the highest vs. lowest quartile of toenail Cr was 0.54 (95% CI: 0.26-1.14; Ptrend=0.189) for the nested case-control study. On stratification for diabetes mellitus (DM), OR was 1.37 (95% CI: 0.54-3.46; Ptrend=0.364) for the DM group, and 0.25 (95% CI: 0.08-0.80; Ptrend=0.030) for the non-DM group (P for interaction=0.078).The present findings, although not statistically significant, are consistent with previously reported inverse associations between TCL and CVD. These results, especially for non-DM patients, increase the limited epidemiological knowledge about the possible protective role of Cr against CVD. (Trial registration: www.controlled-trials.com; ISRCTN35739639.).
    Àrees temàtiques: Saúde coletiva Peripheral vascular disease Medicine (miscellaneous) Medicina iii Medicina ii Medicina i General medicine Farmacia Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 13469843
    Adreça de correu electrònic de l'autor: monica.bullo@urv.cat jordi.salas@urv.cat
    Identificador de l'autor: 0000-0002-0218-7046 0000-0003-2700-7459
    Data d'alta del registre: 2024-10-12
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://www.jstage.jst.go.jp/article/circj/81/8/81_CJ-17-0032/_article
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Circulation Journal. 81 (8): 1183-1190
    Referència de l'ítem segons les normes APA: Gutierrez-Bedmar, Mario; Angel Martinez-Gonzalez, Miguel; Munoz-Bravo, Carlos; Ruiz-Canela, Miguel; Mariscal, Alberto; Salas-Salvado, Jordi; Estruch, (2017). Chromium Exposure and Risk of Cardiovascular Disease in High Cardiovascular Risk Subjects - Nested Case-Control Study in the Prevention With Mediterranean Diet (PREDIMED) Study.. Circulation Journal, 81(8), 1183-1190. DOI: 10.1253/circj.CJ-17-0032
    DOI de l'article: 10.1253/circj.CJ-17-0032
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2017
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine,Medicine (Miscellaneous),Peripheral Vascular Disease
    Toenail biomarker
    Predimed
    Diabetes
    Chromium
    Cardiovascular disease
    Saúde coletiva
    Peripheral vascular disease
    Medicine (miscellaneous)
    Medicina iii
    Medicina ii
    Medicina i
    General medicine
    Farmacia
    Ciências biológicas ii
    Ciências biológicas i
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
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