Articles producció científica> Bioquímica i Biotecnologia

Plasma Metabolites From Choline Pathway and Risk of Cardiovascular Disease in the PREDIMED (Prevention With Mediterranean Diet) Study

  • Dades identificatives

    Identificador: imarina:3177539
    Handle: https://hdl.handle.net/20.500.11797/imarina3177539
    Autors:
    Guasch-Ferre, MartaHu, Frank BRuiz-Canela, MiguelBullo, MonicaToledo, EstefaniaWang, Dong DCorella, DoloresGomez-Gracia, EnriqueFiol, MiquelEstruch, RamonLapetra, JoseFito, MontserratAros, FernandoSerra-Majem, LluisRos, EmilioDennis, CourtneyLiang, LimingClish, Clary BMartinez-Gonzalez, Miguel ASalas-Salvado, Jordi
    Resum:
    The relationship between plasma concentrations of betaine and choline metabolism and major cardiovascular disease (CVD) end points remains unclear. We have evaluated the association between metabolites from the choline pathway and risk of incident CVD and the potential modifying effect of Mediterranean diet interventions.We designed a case-cohort study nested within the PREDIMED (Prevention With Mediterranean Diet) trial, including 229 incident CVD cases and 751 randomly selected participants at baseline, followed up for 4.8 years. We used liquid chromatography-tandem mass spectrometry to measure, at baseline and at 1 year of follow-up, plasma concentrations of 5 metabolites in the choline pathway: trimethylamine N-oxide, betaine, choline, phosphocholine, and ?-glycerophosphocholine. We have calculated a choline metabolite score using a weighted sum of these 5 metabolites. We used weighted Cox regression models to estimate CVD risk. The multivariable hazard ratios (95% confidence intervals) per 1-SD increase in choline and ?-glycerophosphocholine metabolites were 1.24 (1.05-1.46) and 1.24 (1.03-1.50), respectively. The baseline betaine/choline ratio was inversely associated with CVD. The baseline choline metabolite score was associated with a 2.21-fold higher risk of CVD across extreme quartiles (95% confidence interval, 1.36-3.59; P<0.001 for trend) and a 2.27-fold higher risk of stroke (95% confidence interval, 1.24-4.16; P<0.001 for trend). Participants in the higher quartiles of the score who were randomly assigned to the control group had a higher risk of CVD compared with participants in the lower quartile and assigned to the Mediterranean diet groups (P=0.05 for interaction). No significant associations were observed for 1-year changes in individual plasma metabo

  • Altres:

    Autor segons l'article: Guasch-Ferre, Marta; Hu, Frank B; Ruiz-Canela, Miguel; Bullo, Monica; Toledo, Estefania; Wang, Dong D; Corella, Dolores; Gomez-Gracia, Enrique; Fiol, Miquel; Estruch, Ramon; Lapetra, Jose; Fito, Montserrat; Aros, Fernando; Serra-Majem, Lluis; Ros, Emilio; Dennis, Courtney; Liang, Liming; Clish, Clary B; Martinez-Gonzalez, Miguel A; Salas-Salvado, Jordi
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Bulló Bonet, Mònica / Salas Salvadó, Jorge
    Paraules clau: Metabolomics Mediterranean diet Gut microbiota Choline Cardiovascular disease mediterranean diet gut microbiota choline cardiovascular disease
    Resum: The relationship between plasma concentrations of betaine and choline metabolism and major cardiovascular disease (CVD) end points remains unclear. We have evaluated the association between metabolites from the choline pathway and risk of incident CVD and the potential modifying effect of Mediterranean diet interventions.We designed a case-cohort study nested within the PREDIMED (Prevention With Mediterranean Diet) trial, including 229 incident CVD cases and 751 randomly selected participants at baseline, followed up for 4.8 years. We used liquid chromatography-tandem mass spectrometry to measure, at baseline and at 1 year of follow-up, plasma concentrations of 5 metabolites in the choline pathway: trimethylamine N-oxide, betaine, choline, phosphocholine, and ?-glycerophosphocholine. We have calculated a choline metabolite score using a weighted sum of these 5 metabolites. We used weighted Cox regression models to estimate CVD risk. The multivariable hazard ratios (95% confidence intervals) per 1-SD increase in choline and ?-glycerophosphocholine metabolites were 1.24 (1.05-1.46) and 1.24 (1.03-1.50), respectively. The baseline betaine/choline ratio was inversely associated with CVD. The baseline choline metabolite score was associated with a 2.21-fold higher risk of CVD across extreme quartiles (95% confidence interval, 1.36-3.59; P<0.001 for trend) and a 2.27-fold higher risk of stroke (95% confidence interval, 1.24-4.16; P<0.001 for trend). Participants in the higher quartiles of the score who were randomly assigned to the control group had a higher risk of CVD compared with participants in the lower quartile and assigned to the Mediterranean diet groups (P=0.05 for interaction). No significant associations were observed for 1-year changes in individual plasma metabolites and CVD.A metabolite score combining plasma metabolites from the choline pathway was associated with an increased risk of CVD in a Mediterranean population at high cardiovascular risk.URL: http://www.controlled-trials.com. Unique identifier: ISRCTN35739639.© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
    Àrees temàtiques: Saúde coletiva Nutrição Medicina ii Medicina i Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20479980
    Adreça de correu electrònic de l'autor: monica.bullo@urv.cat jordi.salas@urv.cat
    Identificador de l'autor: 0000-0002-0218-7046 0000-0003-2700-7459
    Data d'alta del registre: 2024-10-12
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.ahajournals.org/doi/10.1161/JAHA.117.006524
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Journal Of The American Heart Association. 6 (11): 006524-
    Referència de l'ítem segons les normes APA: Guasch-Ferre, Marta; Hu, Frank B; Ruiz-Canela, Miguel; Bullo, Monica; Toledo, Estefania; Wang, Dong D; Corella, Dolores; Gomez-Gracia, Enrique; Fiol, (2017). Plasma Metabolites From Choline Pathway and Risk of Cardiovascular Disease in the PREDIMED (Prevention With Mediterranean Diet) Study. Journal Of The American Heart Association, 6(11), 006524-. DOI: 10.1161/JAHA.117.006524
    DOI de l'article: 10.1161/JAHA.117.006524
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2017
    Tipus de publicació: Journal Publications

  • Paraules clau:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine
    Metabolomics
    Mediterranean diet
    Gut microbiota
    Choline
    Cardiovascular disease
    mediterranean diet
    gut microbiota
    choline
    cardiovascular disease
    Saúde coletiva
    Nutrição
    Medicina ii
    Medicina i
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
    Biotecnología

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