Articles producció científicaEnginyeria Química

Amperometric supramolecular genosensor self-assembled on cyclodextrin-modified surfaces

  • Dades identificatives

    Identificador:  imarina:3642318
    Handle: https://hdl.handle.net/20.500.11797/imarina3642318
    Autors:  Ortiz, Mayreli; Torrens, Mabel; Alakulppi, Noora; Strombom, Linda; Fragoso, Alex; O'Sullivan, Ciara K
    Resum:
    A novel genosensor platform based on supramolecular interactions has been developed based on the self-assembly of bifunctionalised polymer bearing adamantane and DNA onto cyclodextrin surfaces. The surface chemistry can undergo a controlled regeneration, as revealed by SPR and impedance spectroscopy, has an excellent detection limit of 0.08 nM and demonstrated high selectivity, clearly differentiating between complementary and non-complementary DNA sequences. The performance of the developed genosensor was validated by applying it to the detection of DNA in a real patient sample that had been previously genotyped.

  • Altres:

    Autor segons l'article: Ortiz, Mayreli; Torrens, Mabel; Alakulppi, Noora; Strombom, Linda; Fragoso, Alex; O'Sullivan, Ciara K
    Departament: Enginyeria Química
    Autor/s de la URV: Fragoso Sierra, Alex / O'SULLIVAN, CIARA KATHLEEN / Ortíz Rodríguez, Mayreli / TORRENS DEL VALLE, MABEL
    Paraules clau: Supramolecular chemistry; Genosensor; Cyclodextrin; Amperometry
    Resum: A novel genosensor platform based on supramolecular interactions has been developed based on the self-assembly of bifunctionalised polymer bearing adamantane and DNA onto cyclodextrin surfaces. The surface chemistry can undergo a controlled regeneration, as revealed by SPR and impedance spectroscopy, has an excellent detection limit of 0.08 nM and demonstrated high selectivity, clearly differentiating between complementary and non-complementary DNA sequences. The performance of the developed genosensor was validated by applying it to the detection of DNA in a real patient sample that had been previously genotyped.
    Àrees temàtiques: Química; Medicina ii; Materiais; Interdisciplinar; Farmacia; Ensino; Engenharias iii; Engenharias ii; Electrochemistry; Ciências biológicas i; Biotecnología; Biodiversidade; Astronomia / física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: mayreli.ortiz@urv.cat; mayreli.ortiz@urv.cat; alex.fragoso@urv.cat
    Data d'alta del registre: 2024-10-12
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S1388248111001159
    Referència a l'article segons font original: Electrochemistry Communications. 13 (6): 578-581
    Referència de l'ítem segons les normes APA: Ortiz, Mayreli; Torrens, Mabel; Alakulppi, Noora; Strombom, Linda; Fragoso, Alex; O'Sullivan, Ciara K (2011). Amperometric supramolecular genosensor self-assembled on cyclodextrin-modified surfaces. Electrochemistry Communications, 13(6), 578-581. DOI: 10.1016/j.elecom.2011.03.014
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1016/j.elecom.2011.03.014
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2011
    Tipus de publicació: Journal Publications

  • Paraules clau:

    Electrochemistry
    Supramolecular chemistry
    Genosensor
    Cyclodextrin
    Amperometry
    Química
    Medicina ii
    Materiais
    Interdisciplinar
    Farmacia
    Ensino
    Engenharias iii
    Engenharias ii
    Electrochemistry
    Ciências biológicas i
    Biotecnología
    Biodiversidade
    Astronomia / física

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