Autor segons l'article: del Bas, JM; Caimari, A; Rodriguez-Naranjo, MI; Arola, L; Childs, CE; Chavez, CP; West, AL; Miles, EA; Calder, PC
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Del Bas Prior, José María
Paraules clau: Polyunsaturated fatty acids; Omega-3; Obesity; Lysophospholipid metabolism; Lysophosphatidylethanolamine; Lysophosphatidylcholine; Insulin resistance; Inflammation; Fish oil; Fatty liver disease; omega-3; obesity; lysophospholipid metabolism; lysophosphatidylethanolamine; lysophosphatidylcholine; insulin resistance; inflammation; fish oil; fatty liver disease
Resum: Plasma lysophospholipids have emerged as signaling molecules with important effects on inflammation, insulin resistance, and fatty liver disease, each of which is linked closely to obesity. Dietary n-3 (¿-3) polyunsaturated fatty acids (PUFAs) may be able to improve these conditions. Objective: The objective of this study was to assess the response of plasma lysophospholipids to obesity, n-3 PUFA consumption, and a high-fat meal challenge to better understand the role of lysophospholipid metabolism in the progression of obesity-related disorders. Design: We determined the concentrations of 8 lysophosphatidylcholines, 11 lysophosphatidylethanolamines, and 7 lysophosphatidylinositols in the plasma of 34 normal-weight and 38 obese subjects randomly assigned to consume corn oil (control) or n-3 PUFA-rich fish oil (3 g/d; n = 15-19/group) for 90 d. Blood samples were collected on the last day of the study under fasting conditions and 6 h after a high-fat meal (1135 kcal, 86 g fat) challenge. The profile of secreted lysophospholipids was studied in HepG2 cells under palmitate-induced steatosis. Results: Obese and normal-weight subjects had different profiles of plasma lysophospholipids. A multivariate combination of the 26 lysophospholipids could discriminate between normal-weight and obese subjects with an accuracy of 98%. The high-fat meal challenge altered the concentration of plasma lysophosphatidylcholines in an oil treatment-dependent manner in normal-weight but not obese subjects, suggesting that obesity impairs the sensitivity of lysophospholipid metabolism to n-3 PUFAs. Noncytotoxic steatosis in HepG2 cells affected the secretion pattern of lysophospholipids, partially resembling the changes observed in the plasma of obese subjects. Conclusions: Obesity has a substantial impact on lysophospholipid metabolism, altering the plasma lysophospholipid profile and abolishing its sensitivity to dietary n-3 PUFAs. These effects could contribute to the onset or progression of alterations associated with obesity, such as inflammation, insulin resistance, and fatty liver disease.
Àrees temàtiques: Serviço social; Saúde coletiva; Odontología; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicine (miscellaneous); Medicina iii; Medicina ii; Medicina i; General medicine; Enfermagem; Educação física; Ciências biológicas ii; Ciência de alimentos; Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: josepm.delbas@urv.cat
Data d'alta del registre: 2025-02-17
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/pii/S0002916522045385
Referència a l'article segons font original: American Journal Of Clinical Nutrition. 104 (2): 266-279
Referència de l'ítem segons les normes APA: del Bas, JM; Caimari, A; Rodriguez-Naranjo, MI; Arola, L; Childs, CE; Chavez, CP; West, AL; Miles, EA; Calder, PC (2016). Impairment of lysophospholipid metabolism in obesity: Altered plasma profile and desensitization to the modulatory properties of n-3 polyunsaturated fatty acids in a randomized controlled trial. American Journal Of Clinical Nutrition, 104(2), 266-279. DOI: 10.3945/ajcn.116.130872
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.3945/ajcn.116.130872
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2016
Tipus de publicació: Journal Publications
Repositori URV