Autor segons l'article: Voltas N, Arija V, Hernández-Martínez C, Jiménez-Feijoo R, Ferré N, Canals J
Departament: Psicologia Ciències Mèdiques Bàsiques
Autor/s de la URV: Arija Val, Maria Victoria / Canals Sans, Josefa / Ferre Pallas, Natalia / Hernandez Martinez, Carmen / Voltas Moreso, Núria
Paraules clau: Psychopathology Neurodevelopment Inflammatory biomarkers Infants Il-6 Il-4 Il-1? Cortisol neurodevelopment inflammatory biomarkers infants il-6 il-4 il-1? cortisol
Resum: Few studies have investigated the relationship between post-natal inflammatory biomarkers at early age and child neurodevelopment outcomes. The main aim of this study was to examine the relationship between IL-6, IL-1β, IL-4 cytokines, as well as cortisol at 6 and 12 months of age, and neurodevelopment and psychological problems at 30 months of age. The study was conducted on a sample of 51 full-term newborns who were followed up at 6, 12, and 30 months of age. Infant neurodevelopment was assessed using the Bayley Scales of Infant Development-II, psychological problems were assessed with the Child Behavior Checklist 1.5-5 (CBCL 1.5-5) and the mother's emotional symptoms were assessed with the General Health Questionnaire-28. When the infants were 6 and 12 months old, IL-6, IL-1β, IL-4 cytokines, and cortisol were measured in blood samples. The results showed that higher IL-6 at 12 months predicted higher scores in internalizing (emotionally reactive, anxious/depressed, withdrawn and attention problems) and externalizing problems (aggressive behavior) at 30 months. By contrast, high levels of IL-1β at 6 months were related to worse motor skills. Inflammatory biomarkers were not related to mental performance. IL-6 and IL-1β could be early markers of later psychological problems and psychomotor disabilities.
Àrees temàtiques: Saúde coletiva Psicología Odontología Neurosciences Neurology (clinical) Neurology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Immunology and allergy Immunology General medicine Farmacia Engenharias iv Engenharias ii Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 01655728
Adreça de correu electrònic de l'autor: nuria.voltas@urv.cat carmen.hernandez@urv.cat natalia.ferre@urv.cat josefa.canals@urv.cat victoria.arija@urv.cat
Identificador de l'autor: 0000-0001-8855-0282 0000-0001-6328-8679 0000-0002-2838-1525 0000-0002-6209-9558 0000-0002-1758-0975
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.jni-journal.com/article/S0165-5728(16)30345-9/abstract
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Journal Of Neuroimmunology. 305 42-50
Referència de l'ítem segons les normes APA: Voltas N, Arija V, Hernández-Martínez C, Jiménez-Feijoo R, Ferré N, Canals J (2017). Are there early inflammatory biomarkers that affect neurodevelopment in infancy?. Journal Of Neuroimmunology, 305(), 42-50. DOI: 10.1016/j.jneuroim.2017.01.017
DOI de l'article: 10.1016/j.jneuroim.2017.01.017
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2017
Tipus de publicació: Journal Publications
Repositori URV