Autor segons l'article: Razquin C; Toledo E; Clish CB; Ruiz-Canela M; Dennis C; Corella D; Papandreou C; Ros E; Estruch R; Guasch-Ferré M; Gómez-Gracia E; Fitó M; Yu E; Lapetra J; Wang D; Romaguera D; Liang L; Alonso-Gómez A; Deik A; Bullo M; Serra-Majem L; Salas-Salvadó J; Hu FB; Martínez-González MA
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Bulló Bonet, Mònica / Salas Salvadó, Jorge
Paraules clau: @infoAeu @residentesaeu @uroweb Etiqueta «#» Hashtag
Resum: © 2018 by the American Diabetes Association. OBJECTIVE: Specific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk. RESEARCH DESIGN AND METHODS: We conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline. We repeatedly measured 207 plasma known lipid metabolites at baseline and after 1 year of follow-up. We built combined factors of lipid species using principal component analysis and assessed the association between these lipid factors (or their 1-year changes) and T2D incidence. RESULTS: Baseline lysophosphatidylcholines and lysophosphatidylethanolamines (lysophospholipids [LPs]), phosphatidylcholine-plasmalogens (PC-PLs), sphingomyelins (SMs), and cholesterol esters (CEs) were inversely associated with risk of T2D (multivariable-adjusted P for linear trend ≤0.001 for all). Baseline triacylglycerols (TAGs), diacylglycerols (DAGs), and phosphatidylethanolamines (PEs) were positively associated with T2D risk (multivariable-adjusted P for linear trend <0.001 for all). One-year changes in these lipids showed associations in similar directions but were not significant after adjustment for baseline levels. TAGs with odd-chain fatty acids showed inverse associations with T2D after adjusting for total TAGs. CONCLUSIONS: Two plasma lipid profiles made up of different lipid classes were found to be associated with T2D in participants at high cardiovascular risk. A profile including LPs, PC-PLs, SMs, and CEs was associated with lower T2D risk. Another profile composed of TAGs, DAGs, and PEs was associated with higher T2D risk.
Àrees temàtiques: Advanced and specialized nursing Antropologia / arqueologia Biotecnología Ciências biológicas i Ciências biológicas ii Endocrinology & metabolism Endocrinology, diabetes and metabolism Enfermagem Engenharias iv General medicine Interdisciplinar Internal medicine Medicina i Medicina ii Medicina iii Nutrição Odontología Saúde coletiva
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: monica.bullo@urv.cat jordi.salas@urv.cat
ISSN: 01495992
Identificador de l'autor: 0000-0002-0218-7046 0000-0003-2700-7459
Data d'alta del registre: 2023-02-18
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://diabetesjournals.org/care/article/41/12/2617/36497/Plasma-Lipidomic-Profiling-and-Risk-of-Type-2
Referència a l'article segons font original: Diabetes Care. 41 (12): 2617-2624
Referència de l'ítem segons les normes APA: Razquin C; Toledo E; Clish CB; Ruiz-Canela M; Dennis C; Corella D; Papandreou C; Ros E; Estruch R; Guasch-Ferré M; Gómez-Gracia E; Fitó M; Yu E; Lapet (2018). Plasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial. Diabetes Care, 41(12), 2617-2624. DOI: 10.2337/dc18-0840
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.2337/dc18-0840
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2018
Tipus de publicació: Journal Publications
Repositori URV