Articles producció científica> Bioquímica i Biotecnologia

Plasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial

  • Dades identificatives

    Identificador: imarina:4098950
    Handle: https://hdl.handle.net/20.500.11797/imarina4098950
    Autors:
    Razquin, CristinaToledo, EstefaniaClish, Clary BRuiz-Canela, MiguelDennis, CourtneyCorella, DoloresPapandreou, ChristopherRos, EmilioEstruch, RamonGuasch-Ferre, MartaGomez-Gracia, EnriqueFito, MontserratYu, EdwardLapetra, JoseWang, DongRomaguera, DoraLiang, LimingAlonso-Gomez, AngelDeik, AmyBullo, MonicaSerra-Majem, LluisSalas-Salvado, JordiHu, Frank BMartinez-Gonzalez, Miguel A
    Resum:
    © 2018 by the American Diabetes Association. OBJECTIVE: Specific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk. RESEARCH DESIGN AND METHODS: We conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline. We repeatedly measured 207 plasma known lipid metabolites at baseline and after 1 year of follow-up. We built combined factors of lipid species using principal component analysis and assessed the association between these lipid factors (or their 1-year changes) and T2D incidence. RESULTS: Baseline lysophosphatidylcholines and lysophosphatidylethanolamines (lysophospholipids [LPs]), phosphatidylcholine-plasmalogens (PC-PLs), sphingomyelins (SMs), and cholesterol esters (CEs) were inversely associated with risk of T2D (multivariable-adjusted P for linear trend ≤0.001 for all). Baseline triacylglycerols (TAGs), diacylglycerols (DAGs), and phosphatidylethanolamines (PEs) were positively associated with T2D risk (multivariable-adjusted P for linear trend <0.001 for all). One-year changes in these lipids showed associations in similar directions but were not significant after adjustment for baseline levels. TAGs with odd-chain fatty acids showed inverse associations with T2D after adjusting for total TAGs. CONCLUSIONS: Two plasma lipid profiles made up of different lipid classes were found to be associated with T2D in participants at high cardiovascular risk. A profile including LPs, PC-PLs, SMs, and CEs was associated with lower T2D risk. Another pro

  • Altres:

    Autor segons l'article: Razquin, Cristina; Toledo, Estefania; Clish, Clary B; Ruiz-Canela, Miguel; Dennis, Courtney; Corella, Dolores; Papandreou, Christopher; Ros, Emilio; Estruch, Ramon; Guasch-Ferre, Marta; Gomez-Gracia, Enrique; Fito, Montserrat; Yu, Edward; Lapetra, Jose; Wang, Dong; Romaguera, Dora; Liang, Liming; Alonso-Gomez, Angel; Deik, Amy; Bullo, Monica; Serra-Majem, Lluis; Salas-Salvado, Jordi; Hu, Frank B; Martinez-Gonzalez, Miguel A
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Bulló Bonet, Mònica / Salas Salvadó, Jorge
    Paraules clau: Risk factors Middle aged Metabolomics Male Lipids Lipid metabolism Incidence Humans Female Diabetes mellitus, type 2 Cohort studies Case-control studies Cardiovascular diseases Aged, 80 and over Aged
    Resum: © 2018 by the American Diabetes Association. OBJECTIVE: Specific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk. RESEARCH DESIGN AND METHODS: We conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline. We repeatedly measured 207 plasma known lipid metabolites at baseline and after 1 year of follow-up. We built combined factors of lipid species using principal component analysis and assessed the association between these lipid factors (or their 1-year changes) and T2D incidence. RESULTS: Baseline lysophosphatidylcholines and lysophosphatidylethanolamines (lysophospholipids [LPs]), phosphatidylcholine-plasmalogens (PC-PLs), sphingomyelins (SMs), and cholesterol esters (CEs) were inversely associated with risk of T2D (multivariable-adjusted P for linear trend ≤0.001 for all). Baseline triacylglycerols (TAGs), diacylglycerols (DAGs), and phosphatidylethanolamines (PEs) were positively associated with T2D risk (multivariable-adjusted P for linear trend <0.001 for all). One-year changes in these lipids showed associations in similar directions but were not significant after adjustment for baseline levels. TAGs with odd-chain fatty acids showed inverse associations with T2D after adjusting for total TAGs. CONCLUSIONS: Two plasma lipid profiles made up of different lipid classes were found to be associated with T2D in participants at high cardiovascular risk. A profile including LPs, PC-PLs, SMs, and CEs was associated with lower T2D risk. Another profile composed of TAGs, DAGs, and PEs was associated with higher T2D risk.
    Àrees temàtiques: Saúde coletiva Odontología Nutrição Medicina iii Medicina ii Medicina i Internal medicine Interdisciplinar General medicine Engenharias iv Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i Biotecnología Antropologia / arqueologia Advanced and specialized nursing
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 01495992
    Adreça de correu electrònic de l'autor: monica.bullo@urv.cat jordi.salas@urv.cat
    Identificador de l'autor: 0000-0002-0218-7046 0000-0003-2700-7459
    Data d'alta del registre: 2024-10-12
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://diabetesjournals.org/care/article/41/12/2617/36497/Plasma-Lipidomic-Profiling-and-Risk-of-Type-2
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Diabetes Care. 41 (12): 2617-2624
    Referència de l'ítem segons les normes APA: Razquin, Cristina; Toledo, Estefania; Clish, Clary B; Ruiz-Canela, Miguel; Dennis, Courtney; Corella, Dolores; Papandreou, Christopher; Ros, Emilio; E (2018). Plasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial. Diabetes Care, 41(12), 2617-2624. DOI: 10.2337/dc18-0840
    DOI de l'article: 10.2337/dc18-0840
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2018
    Tipus de publicació: Journal Publications

  • Paraules clau:

    Advanced and Specialized Nursing,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Internal Medicine
    Risk factors
    Middle aged
    Metabolomics
    Male
    Lipids
    Lipid metabolism
    Incidence
    Humans
    Female
    Diabetes mellitus, type 2
    Cohort studies
    Case-control studies
    Cardiovascular diseases
    Aged, 80 and over
    Aged
    Saúde coletiva
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Internal medicine
    Interdisciplinar
    General medicine
    Engenharias iv
    Enfermagem
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Antropologia / arqueologia
    Advanced and specialized nursing

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