Autor segons l'article: Chaffin, Mark D; Cao, Liu; Deik, Amy A; Clish, Clary B; Hu, Frank B; Martinez-Gonzalez, Miguel A; Razquin, Cristina; Bullo, Monica; Corella, Dolores; Gomez-Gracia, Enrique; Fiol, Miguel; Estruch, Ramon; Lapetra, Jose; Fito, Montserrat; Aros, Fernando; Serra-Majem, Lluis; Ros, Emilio; Liang, Liming
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Bulló Bonet, Mònica
Paraules clau: Untargeted metabolomics Pooled qc sample Missing pattern Measurement artifact Large-scale Design Cardiovascular-disease pooled qc sample missing pattern measurement artifact
Resum: Copyright © 2018 American Chemical Society. High-throughput metabolomics using liquid chromatography and mass spectrometry (LC/MS) provides a useful method to identify biomarkers of disease and explore biological systems. However, the majority of metabolic features detected from untargeted metabolomics experiments have unknown ion signatures, making it critical that data should be thoroughly quality controlled to avoid analyzing false signals. Here, we present a postalignment method relying on intermittent pooled study samples to separate genuine metabolic features from potential measurement artifacts. We apply the method to lipid metabolite data from the PREDIMED (PREvención con DIeta MEDi-terránea) study to demonstrate clear removal of measurement artifacts. The method is publicly available as the R package MetProc, available on CRAN under the GPL-v2 license.
Àrees temàtiques: Química Odontología Medicina veterinaria Medicina ii Medicina i Interdisciplinar General chemistry Farmacia Engenharias iii Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry (miscellaneous) Chemistry (all) Biotecnología Biodiversidade Biochemistry Biochemical research methods Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 15353893
Adreça de correu electrònic de l'autor: monica.bullo@urv.cat
Identificador de l'autor: 0000-0002-0218-7046
Data d'alta del registre: 2024-10-12
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://pubs.acs.org/doi/10.1021/acs.jproteome.8b00893#
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Journal Of Proteome Research. 18 (3): 1446-1450
Referència de l'ítem segons les normes APA: Chaffin, Mark D; Cao, Liu; Deik, Amy A; Clish, Clary B; Hu, Frank B; Martinez-Gonzalez, Miguel A; Razquin, Cristina; Bullo, Monica; Corella, Dolores; (2019). MetProc: Separating Measurement Artifacts from True Metabolites in an Untargeted Metabolomics Experiment. Journal Of Proteome Research, 18(3), 1446-1450. DOI: 10.1021/acs.jproteome.8b00893
DOI de l'article: 10.1021/acs.jproteome.8b00893
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Tipus de publicació: Journal Publications
Repositori URV