Articles producció científica> Ciències Mèdiques Bàsiques

Effects of C282Y, H63D, and S65C HFE gene mutations, diet, and life-style factors on iron status in a general Mediterranean population from Tarragona, Spain

  • Dades identificatives

    Identificador: imarina:5122287
    Autors:
    Aranda N, Viteri FE, Montserrat C, Arija V
    Resum:
    Mutations in the HFE gene result in iron overload and can produce hereditary hemochromatosis (HH), a disorder of iron metabolism characterized by increased intestinal iron absorption. Dietary quality, alcoholism and other life-style factors can increase the risk of iron overload, especially among genetically at risk populations. Polymorphisms of the HFE gene (C282Y, H63D and S65C) were measured together with serum ferritin (SF), transferrin saturation (TS) and hemoglobin, to measure iron status, in randomly-selected healthy subjects living in the Spanish Mediterranean coast (n = 815; 425 females, 390 males), 18 to 75 years of age. The intake of dietary components that affect iron absorption was calculated from 3-day dietary records. The presence of C282Y/H63D compound heterozygote that had a prevalence of 2.8% in males and 1.2% in females was associated with an elevated TS and SF. No subject was homozygous for C282Y or S65C. The C282Y heterozygote, H63D heterozygote and homozygote and H63D/S65C compound heterozygote genotypes were associated with increased TS relative to the wild type in the general population. These genotypes together with the alcohol and iron intake increase the indicators of iron status, while calcium intake decreases them. We did not observe any affect of the S65C heterozygote genotype on these levels. All the HFE genotypes except for the S65C heterozygote together with the alcohol, iron and calcium intake affect the indicators of iron status. The C282Y/H63D compound heterozygote genotype has the higher phenotypic expression in our Spanish Mediterranean population.
  • Altres:

    Autor segons l'article: Aranda N, Viteri FE, Montserrat C, Arija V
    Departament: Ciències Mèdiques Bàsiques
    e-ISSN: 1432-0584
    Autor/s de la URV: Aranda Pons, Núria / Arija Val, Maria Victoria
    Paraules clau: Stores Serum ferritin S65c variant Risk Overload Middle-aged women Mediterranean diet Iron overload Hfe gene Hereditary hemochromatosis Heme iron H63d variant Genética-nutrición Estilos de vida Disease C282yvariant Atherosclerosis Association sobrecarga de hierro
    Resum: Mutations in the HFE gene result in iron overload and can produce hereditary hemochromatosis (HH), a disorder of iron metabolism characterized by increased intestinal iron absorption. Dietary quality, alcoholism and other life-style factors can increase the risk of iron overload, especially among genetically at risk populations. Polymorphisms of the HFE gene (C282Y, H63D and S65C) were measured together with serum ferritin (SF), transferrin saturation (TS) and hemoglobin, to measure iron status, in randomly-selected healthy subjects living in the Spanish Mediterranean coast (n = 815; 425 females, 390 males), 18 to 75 years of age. The intake of dietary components that affect iron absorption was calculated from 3-day dietary records. The presence of C282Y/H63D compound heterozygote that had a prevalence of 2.8% in males and 1.2% in females was associated with an elevated TS and SF. No subject was homozygous for C282Y or S65C. The C282Y heterozygote, H63D heterozygote and homozygote and H63D/S65C compound heterozygote genotypes were associated with increased TS relative to the wild type in the general population. These genotypes together with the alcohol and iron intake increase the indicators of iron status, while calcium intake decreases them. We did not observe any affect of the S65C heterozygote genotype on these levels. All the HFE genotypes except for the S65C heterozygote together with the alcohol, iron and calcium intake affect the indicators of iron status. The C282Y/H63D compound heterozygote genotype has the higher phenotypic expression in our Spanish Mediterranean population.
    Àrees temàtiques: Saúde coletiva Química Odontología Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar Hematology General medicine Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0939-5555
    Adreça de correu electrònic de l'autor: nuria.aranda@urv.cat victoria.arija@urv.cat
    Identificador de l'autor: 0000-0001-9708-747X 0000-0002-1758-0975
    Pàgina final: 773
    Data d'alta del registre: 2023-02-18
    Volum de revista: 89
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://link.springer.com/article/10.1007/s00277-010-0901-9
    Referència a l'article segons font original: Annals Of Hematology. 89 (8): 767-773
    Referència de l'ítem segons les normes APA: Aranda N, Viteri FE, Montserrat C, Arija V (2010). Effects of C282Y, H63D, and S65C HFE gene mutations, diet, and life-style factors on iron status in a general Mediterranean population from Tarragona, Spain. Annals Of Hematology, 89(8), 767-773. DOI: 10.1007/s00277-010-0901-9
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1007/s00277-010-0901-9
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2010
    Pàgina inicial: 767
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Hematology,Medicine (Miscellaneous)
    Stores
    Serum ferritin
    S65c variant
    Risk
    Overload
    Middle-aged women
    Mediterranean diet
    Iron overload
    Hfe gene
    Hereditary hemochromatosis
    Heme iron
    H63d variant
    Genética-nutrición
    Estilos de vida
    Disease
    C282yvariant
    Atherosclerosis
    Association
    sobrecarga de hierro
    Saúde coletiva
    Química
    Odontología
    Medicine (miscellaneous)
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Hematology
    General medicine
    Farmacia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
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