Articles producció científica> Medicina i Cirurgia

Role of the fatty acid-binding protein 4 in heart failure and cardiovascular disease

  • Dades identificatives

    Identificador: imarina:5130965
    Autors:
    Rodríguez-Calvo, RGirona, JAlegret, JMBosquet, AIbarretxe, DMasana, L
    Resum:
    Obesity and ectopic fat accumulation in non-adipose tissues are major contributors to heart failure (HF) and cardiovascular disease (CVD). Adipocytes act as endocrine organs by releasing a large number of bioactive molecules into the bloodstream, which participate in a communication network between white adipose tissue and other organs, including the heart. Among these molecules, fatty acid binding protein 4 (FABP4) has been recently shown to increase cardiometabolic risk. Both clinical and experimental evidence have identified FABP4 as a relevant player in atherosclerosis and coronary artery disease, and it has been directly related to cardiac alterations such as left ventricular hypertrophy (LVH) or both systolic and diastolic cardiac dysfunction. The available interventional studies preclude the establishment of a direct causal role of this molecule in CVD and HF and propose FABP4 as a biomarker rather than as an aetiological factor. However, several experimental reports have suggested that FABP4 may act as a direct contributor in cardiac metabolism and physiopathology, and pharmacological targeting of FABP4 may restore some of the metabolic alterations that are conducive to CVD and HF. Here, we review the current knowledge of FABP4 with regard to HF and CVD as well as the molecular basis of how this protein participates in the regulation of cardiac function.
  • Altres:

    Autor segons l'article: Rodríguez-Calvo, R; Girona, J; Alegret, JM; Bosquet, A; Ibarretxe, D; Masana, L
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Alegret Colomé, Josep Maria / BOSQUET AGUDO, ALBA / Girona Tell, Josefa / Ibarretxe Gerediaga, Daiana / Masana Marín, Luis
    Paraules clau: Heart failure Fabp4 Cardiovascular disease Adipokines fabp4 cardiovascular disease adipokines
    Resum: Obesity and ectopic fat accumulation in non-adipose tissues are major contributors to heart failure (HF) and cardiovascular disease (CVD). Adipocytes act as endocrine organs by releasing a large number of bioactive molecules into the bloodstream, which participate in a communication network between white adipose tissue and other organs, including the heart. Among these molecules, fatty acid binding protein 4 (FABP4) has been recently shown to increase cardiometabolic risk. Both clinical and experimental evidence have identified FABP4 as a relevant player in atherosclerosis and coronary artery disease, and it has been directly related to cardiac alterations such as left ventricular hypertrophy (LVH) or both systolic and diastolic cardiac dysfunction. The available interventional studies preclude the establishment of a direct causal role of this molecule in CVD and HF and propose FABP4 as a biomarker rather than as an aetiological factor. However, several experimental reports have suggested that FABP4 may act as a direct contributor in cardiac metabolism and physiopathology, and pharmacological targeting of FABP4 may restore some of the metabolic alterations that are conducive to CVD and HF. Here, we review the current knowledge of FABP4 with regard to HF and CVD as well as the molecular basis of how this protein participates in the regulation of cardiac function.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Química Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar General medicine Farmacia Engenharias iv Engenharias iii Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Endocrinology Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología Biodiversidade
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00220795
    Adreça de correu electrònic de l'autor: daiana.ibarretxe@urv.cat josefa.girona@urv.cat josefa.girona@urv.cat josepmaria.alegret@urv.cat luis.masana@urv.cat
    Identificador de l'autor: 0000-0002-6267-8779 0000-0002-6267-8779 0000-0002-6117-5512 0000-0002-0789-4954
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://joe.bioscientifica.com/view/journals/joe/233/3/R173.xml
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Journal Of Endocrinology. 233 (3): R173-R184
    Referència de l'ítem segons les normes APA: Rodríguez-Calvo, R; Girona, J; Alegret, JM; Bosquet, A; Ibarretxe, D; Masana, L (2017). Role of the fatty acid-binding protein 4 in heart failure and cardiovascular disease. Journal Of Endocrinology, 233(3), R173-R184. DOI: 10.1530/JOE-17-0031
    DOI de l'article: 10.1530/JOE-17-0031
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2017
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Endocrinology,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism
    Heart failure
    Fabp4
    Cardiovascular disease
    Adipokines
    fabp4
    cardiovascular disease
    adipokines
    Zootecnia / recursos pesqueiros
    Química
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Engenharias iii
    Enfermagem
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Endocrinology
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
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