Articles producció científica> Química Analítica i Química Orgànica

Determination of seven drugs of abuse and their metabolites in surface and waste water using solid-phase extraction coupled to liquid chromatography-high resolution mass spectrometry

  • Dades identificatives

    Identificador: imarina:5131722
    Autors:
    Prosen, HelenaFontanals, NuriaBorrull, FrancescMaria Marce, Rosa
    Resum:
    A method based on liquid chromatography with electrospray ionization high-resolution mass spectrometry (Exactive Orbitrap) combined with solid-phase extraction using a strong cationic exchange mixed-mode sorbent has been developed for the determination of seven drugs of abuse, including two synthetic cathinones, as well as some of their metabolites in environmental water samples. The method provides low detection limits and a high confirmation power thanks to the diagnostic and two fragment ions monitored for each compound in high-resolution mass spectrometry, providing six identification points for each analyte. The clean-up step based on methanol in the extraction step adequately decreased the matrix effect, mainly for river and effluent water, and provided suitable process efficiency. Method detection and quantitation limits for environmental waters were at low nanogram per liter. The method was applied to analyze the samples of influent and effluent wastewater, as well as surface water. Codeine, methadone, and its metabolite were determined in all samples of wastewater and the metabolite of cocaine, benzoylecgonine, was found at the highest concentration.
  • Altres:

    Autor segons l'article: Prosen, Helena; Fontanals, Nuria; Borrull, Francesc; Maria Marce, Rosa
    Departament: Química Analítica i Química Orgànica
    Autor/s de la URV: Borrull Ballarín, Francesc / Fontanals Torroja, Núria / Marcé Recasens, Rosa Maria
    Paraules clau: Spain Solid phase extraction Sewage-sludge Selective determination Samples Psychoactive substances Pharmaceuticals Performance Mixed-mode solid-phase extraction Mixed mode ionic exchange sorbents Liquid chromatography-orbitrap-high resolution mass spectrometry Lc-ms/ms Illicit drugs High-resolution mass spectrometry Environmental water samples Environmental water Drugs of abuse Cathinones high-resolution mass spectrometry environmental water samples drugs of abuse cathinones
    Resum: A method based on liquid chromatography with electrospray ionization high-resolution mass spectrometry (Exactive Orbitrap) combined with solid-phase extraction using a strong cationic exchange mixed-mode sorbent has been developed for the determination of seven drugs of abuse, including two synthetic cathinones, as well as some of their metabolites in environmental water samples. The method provides low detection limits and a high confirmation power thanks to the diagnostic and two fragment ions monitored for each compound in high-resolution mass spectrometry, providing six identification points for each analyte. The clean-up step based on methanol in the extraction step adequately decreased the matrix effect, mainly for river and effluent water, and provided suitable process efficiency. Method detection and quantitation limits for environmental waters were at low nanogram per liter. The method was applied to analyze the samples of influent and effluent wastewater, as well as surface water. Codeine, methadone, and its metabolite were determined in all samples of wastewater and the metabolite of cocaine, benzoylecgonine, was found at the highest concentration.
    Àrees temàtiques: Química Psicología Medicina ii Medicina i Materiais Linguística e literatura Interdisciplinar Filtration and separation Farmacia Engenharias iii Engenharias ii Engenharias i Ciências da religião e teologia Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, analytical Biotecnología Biodiversidade Analytical chemistry
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: nuria.fontanals@urv.cat nuria.fontanals@urv.cat rosamaria.marce@urv.cat francesc.borrull@urv.cat
    Identificador de l'autor: 0000-0002-7534-1964 0000-0002-7534-1964 0000-0002-5667-2899 0000-0003-2718-9336
    Data d'alta del registre: 2024-10-12
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://onlinelibrary.wiley.com/doi/abs/10.1002/jssc.201700287
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Journal Of Separation Science. 40 (18): 3621-3631
    Referència de l'ítem segons les normes APA: Prosen, Helena; Fontanals, Nuria; Borrull, Francesc; Maria Marce, Rosa (2017). Determination of seven drugs of abuse and their metabolites in surface and waste water using solid-phase extraction coupled to liquid chromatography-high resolution mass spectrometry. Journal Of Separation Science, 40(18), 3621-3631. DOI: 10.1002/jssc.201700287
    DOI de l'article: 10.1002/jssc.201700287
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2017
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Analytical Chemistry,Chemistry, Analytical,Filtration and Separation
    Spain
    Solid phase extraction
    Sewage-sludge
    Selective determination
    Samples
    Psychoactive substances
    Pharmaceuticals
    Performance
    Mixed-mode solid-phase extraction
    Mixed mode ionic exchange sorbents
    Liquid chromatography-orbitrap-high resolution mass spectrometry
    Lc-ms/ms
    Illicit drugs
    High-resolution mass spectrometry
    Environmental water samples
    Environmental water
    Drugs of abuse
    Cathinones
    high-resolution mass spectrometry
    environmental water samples
    drugs of abuse
    cathinones
    Química
    Psicología
    Medicina ii
    Medicina i
    Materiais
    Linguística e literatura
    Interdisciplinar
    Filtration and separation
    Farmacia
    Engenharias iii
    Engenharias ii
    Engenharias i
    Ciências da religião e teologia
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, analytical
    Biotecnología
    Biodiversidade
    Analytical chemistry
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