Autor segons l'article: Taverner, D; Vallvé, JC; Ferré, R; Paredes, S; Masana, L; Castro, A
Departament: Medicina i Cirurgia
Autor/s de la URV: Castro Salomó, Antoni / FERRÉ VALLÈS, RAIMON / Masana Marín, Luis / Paredes Gonzalez-Albo, Silvia Remedios / Vallvé Torrente, Joan Carles
Paraules clau: Risk-factors Metaanalysis Low-density-lipoprotein Intima-media thickness Coronary-artery-disease Carotid plaque Cardiovascular-disease C-reactive protein B-mode ultrasound Antibodies
Resum: OBJECTIVE: To advance the study of variables associated with subclinical atherosclerosis in rheumatoid arthritis (RA) with special consideration for the degree of disease activity, age and gender. METHODS: The carotid intima-media thickness (cIMT) and the presence of carotid atherosclerotic plaques along with clinical and biochemical characteristics were determined in 214 RA patients. RESULTS: Adjusted analysis reveals that men had a 0.059 mm significantly increased cIMT compared with women (p = 0.001; R2 = 3.8%) and that age was associated with cIMT (β = 0.0048 mm; p = 0.0001; R2 = 16%). Interestingly, we observed a significant interaction between gender and age. Thus, the effect of age on cIMT was significantly increased (12%) in men compared with women (p-value for interaction term = 0.041). Moreover, adjusted multivariable linear regression analysis revealed that disease activity score (DAS28) was significantly associated with cIMT in women (β = 0.021; p = 0.018: R2 = 0.03) but not men. In particular, women with high disease activity had a 0.079 mm increased cIMT compared with women in remission (p = 0.026). In addition, men in remission had a 0.134 mm increased cIMT compared with women in remission (p = 0.003; R2 = 8.7%). Active patients did not exhibit differences in cIMT values. Furthermore, 43% of patients presented carotid plaques. The variables independently associated with carotid plaques were age, smoking, health assessment questionnaire, erythrocyte sedimentation rate and rheumatoid factor (p<0.0001; R2 = 46%). CONCLUSION:In our cohort of patients with RA, DAS28 and age are differentially associated with cIMT in men and women. Our findings could explain the contradictory results that have previously been published in the literature.
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Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 19326203
Adreça de correu electrònic de l'autor: silviaremedios.paredes@urv.cat jc.vallve@urv.cat jc.vallve@urv.cat antoni.castro@urv.cat luis.masana@urv.cat
Identificador de l'autor: 0000-0001-5441-6333 0000-0002-0789-4954
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193690
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Plos One. 13 (3): e0193690-
Referència de l'ítem segons les normes APA: Taverner, D; Vallvé, JC; Ferré, R; Paredes, S; Masana, L; Castro, A (2018). Variables associated with subclinical atherosclerosis in a cohort of rheumatoid arthritis patients: Sex-specific associations and differential effects of disease activity and age. Plos One, 13(3), e0193690-. DOI: 10.1371/journal.pone.0193690
DOI de l'article: 10.1371/journal.pone.0193690
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2018
Tipus de publicació: Journal Publications