Autor segons l'article: Comino, Isabel; Segura, Veronica; Ortigosa, Luis; Espin, Beatriz; Castillejo, Gemma; Antonio Garrote, Jose; Sierra, Carlos; Millan, Antonio; Ribes-Koninckx, Carmen; Roman, Enriqueta; Rodriguez-Herrera, Alfonso; Diaz, Jacobo; Silvester, Jocelyn Anne; Cebolla, Angel; Sousa, Carolina;
Departament: Medicina i Cirurgia
Autor/s de la URV: Castillejo De Villasante, Gemma
Paraules clau: Transglutaminase Quality-of-life Mucosal recovery Management Guidelines Food Follow-up Antibodies Adults Adherence
Resum: Background Treatment for coeliac disease is a lifelong strict gluten-free diet. Although guidelines recommend regular follow-up with dietary interviews and coeliac serology, these methods may be inaccurate. Aim To evaluate the usefulness of faecal gluten immunogenic peptides to support the diagnosis and to determine the adherence to the gluten-free diet in coeliac children. Methods Multicentre prospective observational study including 64 coeliac children. Faecal gluten peptides, and tissue transglutaminase and deamidated gliadin peptide antibodies were analyzed at diagnosis, and 6, 12 and 24 months thereafter. Gluten consumption was estimated from gluten peptide levels. Results Most children (97%) had detectable gluten peptides at diagnosis. On a gluten-free diet, the rate of gluten peptides increased from 13% at 6 months to 25% at 24 months. Mean estimated gluten exposure dropped from 5543 mg/d at diagnosis to 144 mg/d at 6 months, then increased to 606 mg/d by 24 months. In contrast, deamidated gliadin peptide antibodies normalised and only 20% had elevated tissue transglutaminase antibody by 24 months. The elevation of tissue transglutaminase antibody was more prolonged in patients with detectable gluten peptides (P < 0.05). Nevertheless, absolute levels of tissue transglutaminase antibody had low sensitivity to identify patients with detectable gluten peptides (P > 0.1). Dietitian assessment was only moderately correlated with gluten peptide detection (kappa = 0.5). Conclusions Faecal gluten peptides testing may guide treatment of coeliac disease prior to diagnosis and during the assessment diet adherence. Further studies could determine if early identification of gluten exposure reduces the need for expensive/invasive investigations for non-responsive coeliac disease. ClinicalTrials.gov Number: NCT02711397.
Àrees temàtiques: Pharmacology (medical) Pharmacology & pharmacy Odontología Medicina ii Medicina i Hepatology General medicine Gastroenterology & hepatology Gastroenterology Ciências biológicas ii
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 02692813
Adreça de correu electrònic de l'autor: gemma.castillejo@urv.cat
Data d'alta del registre: 2023-02-22
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://onlinelibrary.wiley.com/doi/full/10.1111/apt.15277
Referència a l'article segons font original: Alimentary Pharmacology & Therapeutics. 49 (12): 1484-1492
Referència de l'ítem segons les normes APA: Comino, Isabel; Segura, Veronica; Ortigosa, Luis; Espin, Beatriz; Castillejo, Gemma; Antonio Garrote, Jose; Sierra, Carlos; Millan, Antonio; Ribes-Kon (2019). Prospective longitudinal study: use of faecal gluten immunogenic peptides to monitor children diagnosed with coeliac disease during transition to a gluten-free diet. Alimentary Pharmacology & Therapeutics, 49(12), 1484-1492. DOI: 10.1111/apt.15277
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1111/apt.15277
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Tipus de publicació: Journal Publications
Repositori URV