Autor segons l'article: Hernandez-Alonso, Pablo; Papandreou, Christopher; Bullo, Monica; Ruiz-Canela, Miguel; Dennis, Courtney; Deik, Amy; Wang, Dong D.; Guasch-Ferre, Marta; Yu, Edward; Toledo, Estefania; Razquin, Cristina; Corella, Dolores; Estruch, Ramon; Ros, Emilio; Fito, Montserrat; Aros, Fernando; Fiol, Miquel; Serra-Majem, Lluis; Liang, Liming; Clish, Clary B.; Martinez-Gonzalez, Miguel A.; Hu, Frank B.; Salas-Salvado, Jordi;
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Bulló Bonet, Mònica / Salas Salvadó, Jorge
Paraules clau: lc-ms lipidomics metabolites metabolomics Alcohol-consumption Biomarker Cardiovascular-disease Discovery Lc-ms Lipidomics Metabolites Metabolomics Red wine Resveratrol Risk
Resum: Scope The relationship between red wine (RW) consumption and metabolism is poorly understood. It is aimed to assess the systemic metabolomic profiles in relation to frequent RW consumption as well as the ability of a set of metabolites to discriminate RW consumers. Methods and results A cross-sectional analysis of 1157 participants is carried out. Subjects are divided as non-RW consumers versus RW consumers (>1 glass per day RW [100 mL per day]). Plasma metabolomics analysis is performed using LC-MS. Associations between 386 identified metabolites and RW consumption are assessed using elastic net regression analysis taking into consideration baseline significant covariates. Ten-cross-validation (CV) is performed and receiver operating characteristic curves are constructed in each of the validation datasets based on weighted models. A subset of 13 metabolites is consistently selected and RW consumers versus nonconsumers are discriminated. Based on the multi-metabolite model weighted with the regression coefficients of metabolites, the area under the curve is 0.83 (95% CI: 0.80-0.86). These metabolites mainly consisted of lipid species, some organic acids, and alkaloids. Conclusions A multi-metabolite model identified in a Mediterranean population appears useful to discriminate between frequent RW consumers and nonconsumers. Further studies are needed to assess the contribution of these metabolites in health and disease.
Àrees temàtiques: Astronomia / física Biotechnology Biotecnología Ciência de alimentos Ciências agrárias i Ciências biológicas i Ciências biológicas ii Educação física Farmacia Food science Food science & technology Interdisciplinar Medicina i Medicina ii Medicina veterinaria Nutrição Química Saúde coletiva
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: monica.bullo@urv.cat jordi.salas@urv.cat
ISSN: 16134125
Identificador de l'autor: 0000-0002-0218-7046 0000-0003-2700-7459
Data d'alta del registre: 2023-02-18
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.201900140
Referència a l'article segons font original: Molecular Nutrition & Food Research. 63 (17): e1900140-
Referència de l'ítem segons les normes APA: Hernandez-Alonso, Pablo; Papandreou, Christopher; Bullo, Monica; Ruiz-Canela, Miguel; Dennis, Courtney; Deik, Amy; Wang, Dong D.; Guasch-Ferre, Marta; (2019). Plasma Metabolites Associated with Frequent Red Wine Consumption: A Metabolomics Approach within the PREDIMED Study. Molecular Nutrition & Food Research, 63(17), e1900140-. DOI: 10.1002/mnfr.201900140
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1002/mnfr.201900140
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Tipus de publicació: Journal Publications
Repositori URV