Articles producció científica> Medicina i Cirurgia

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

  • Dades identificatives

    Identificador: imarina:5871132
    Autors:
    Huang, TaoWang, TiangeZheng, YanEllervik, ChristinaGao, MengFang, ZheChai, Jin-FangAhluwalia, Tarun Veer SWang, YujieVoortman, TrudyNoordam, RaymondFrazier-Wood, AlexisScholz, MarkusSonestedt, EmilyAkiyama, MasatoDorajoo, RajkumarZhou, AngKilpelainen, Tuomas OKleber, Marcus ECrozier, Sarah RGodfrey, Keith MLemaitre, RozennFelix, Janine FShi, YuanGupta, PreetiKhor, Chiea-ChuenLehtimaki, TerhoWang, Carol ATiesler, Carla M TThiering, ElisabethStandl, MarieRzehak, PeterMarouli, EiriniHe, MeianLecoeur, CecileCorella, DoloresLai, Chao-QiangMoreno, Luis APitkanen, NiinaBoreham, Colin AZhang, TaoSaw, Seang MeiRidker, Paul MGraff, MariaelisaVan Rooij, Frank J AUitterlinden, Andre GHofman, Albertvan Heemst, DianaRosendaal, Frits Rde Mutsert, ReneeBurkhardt, RalphSchulz, Christina-AlexandraEricson, UlrikaKamatani, YoichiroYuan, Jian-MinPower, ChrisHansen, TorbenSorensen, Thorkild I ATjonneland, AnneOvervad, KimDelgado, GracielaCooper, CyrusDjousse, LucRivadeneira, FernandoJameson, KarenZhao, WantingLiu, JianjunLee, Nanette RRaitakari, OlliKahonen, MikaViikari, JormaGrote, VeitLanghendries, Jean-PaulKoletzko, BertholdEscribano, JoaquinVerduci, ElviraDedoussis, GeorgeYu, CaizhengTham, Yih ChungLim, BlancheLim, Sing HuiFroguel, PhilippeBalkau, BeverleyFink, Nadia RVinding, Rebecca KSevelsted, AstridBisgaard, HansColtell, OscarDallongeville, JeanGottrand, FredericPahkala, KatjaNiinikoski, HarriHypponen, ElinaPedersen, OlufMarz, WinfriedInskip, HazelJaddoe, VincentW VDennison, ElaineYinWong, TienSabanayagam, CharumathiTai, E-ShyongMohlke, Karen LMackey, David AGruszfeld, DariuszDel
    Resum:
    Importance: Observational studies have shown associations of birth weight with type 2 diabetes (T2D) and glycemic traits, but it remains unclear whether these associations represent causal associations. Objective: To test the association of birth weight with T2D and glycemic traits using a mendelian randomization analysis. Design, Setting, and Participants: This mendelian randomization study used a genetic risk score for birth weight that was constructed with 7 genome-wide significant single-nucleotide polymorphisms. The associations of this score with birth weight and T2D were tested in a mendelian randomization analysis using study-level data. The association of birth weight with T2D was tested using both study-level data (7 single-nucleotide polymorphisms were used as an instrumental variable) and summary-level data from the consortia (43 single-nucleotide polymorphisms were used as an instrumental variable). Data from 180 056 participants from 49 studies were included. Main Outcomes and Measures: Type 2 diabetes and glycemic traits. Results: This mendelian randomization analysis included 49 studies with 41 155 patients with T2D and 80 008 control participants from study-level data and 34 840 patients with T2D and 114 981 control participants from summary-level data. Study-level data showed that a 1-SD decrease in birth weight due to the genetic risk score was associated with higher risk of T2D among all participants (odds ratio [OR], 2.10; 95% CI, 1.69-2.61; P = 4.03 × 10-5), among European participants (OR, 1.96; 95% CI, 1.42-2.71; P = .04), and among East Asian participants (OR, 1.39; 95% CI, 1.18-1.62; P = .04). Similar results were observed from summary-level analyses. In addition, each 1-SD lower birth weight was associated with 0.189 SD higher fasting glucose
  • Altres:

    Autor segons l'article: Huang, Tao; Wang, Tiange; Zheng, Yan; Ellervik, Christina; Gao, Meng; Fang, Zhe; Chai, Jin-Fang; Ahluwalia, Tarun Veer S; Wang, Yujie; Voortman, Trudy; Noordam, Raymond; Frazier-Wood, Alexis; Scholz, Markus; Sonestedt, Emily; Akiyama, Masato; Dorajoo, Rajkumar; Zhou, Ang; Kilpelainen, Tuomas O; Kleber, Marcus E; Crozier, Sarah R; Godfrey, Keith M; Lemaitre, Rozenn; Felix, Janine F; Shi, Yuan; Gupta, Preeti; Khor, Chiea-Chuen; Lehtimaki, Terho; Wang, Carol A; Tiesler, Carla M T; Thiering, Elisabeth; Standl, Marie; Rzehak, Peter; Marouli, Eirini; He, Meian; Lecoeur, Cecile; Corella, Dolores; Lai, Chao-Qiang; Moreno, Luis A; Pitkanen, Niina; Boreham, Colin A; Zhang, Tao; Saw, Seang Mei; Ridker, Paul M; Graff, Mariaelisa; Van Rooij, Frank J A; Uitterlinden, Andre G; Hofman, Albert; van Heemst, Diana; Rosendaal, Frits R; de Mutsert, Renee; Burkhardt, Ralph; Schulz, Christina-Alexandra; Ericson, Ulrika; Kamatani, Yoichiro; Yuan, Jian-Min; Power, Chris; Hansen, Torben; Sorensen, Thorkild I A; Tjonneland, Anne; Overvad, Kim; Delgado, Graciela; Cooper, Cyrus; Djousse, Luc; Rivadeneira, Fernando; Jameson, Karen; Zhao, Wanting; Liu, Jianjun; Lee, Nanette R; Raitakari, Olli; Kahonen, Mika; Viikari, Jorma; Grote, Veit; Langhendries, Jean-Paul; Koletzko, Berthold; Escribano, Joaquin; Verduci, Elvira; Dedoussis, George; Yu, Caizheng; Tham, Yih Chung; Lim, Blanche; Lim, Sing Hui; Froguel, Philippe; Balkau, Beverley; Fink, Nadia R; Vinding, Rebecca K; Sevelsted, Astrid; Bisgaard, Hans; Coltell, Oscar; Dallongeville, Jean; Gottrand, Frederic; Pahkala, Katja; Niinikoski, Harri; Hypponen, Elina; Pedersen, Oluf; Marz, Winfried; Inskip, Hazel; Jaddoe, VincentW V; Dennison, Elaine; YinWong, Tien; Sabanayagam, Charumathi; Tai, E-Shyong; Mohlke, Karen L; Mackey, David A; Gruszfeld, Dariusz; Deloukas, Panagiotis; Tucker, Katherine L; Fumeron, Frederic; Bonnelykke, Klaus; Rossing, Peter; Estruch, Ramon; Ordovas, Jose M; Arnett, Donna K; Meirhaeghe, Aline; Amouyel, Philippe; Cheng, Ching-Yu; Sim, Xueling; Teo, Yik Ying; van Dam, Robm M; Koh, Woon-Puay; Orho-Melander, Marju; Loeffler, Markus; Kubo, Michiaki; Thiery, Joachim; Mook-Kanamori, Dennis O; Mozaffarian, Dariush; Psaty, Bruce M; Franco, Oscar H; Wu, Tangchun; North, Kari E; Smith, George Davey; Chavarro, Jorge E; Chasman, Daniel I; Qi, Lu
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Escribano Subías, Joaquín
    Paraules clau: Thrifty phenotype Risk Loci Instruments Heterogeneity Genotype Genome-wide association Consumption Common variants Bias
    Resum: Importance: Observational studies have shown associations of birth weight with type 2 diabetes (T2D) and glycemic traits, but it remains unclear whether these associations represent causal associations. Objective: To test the association of birth weight with T2D and glycemic traits using a mendelian randomization analysis. Design, Setting, and Participants: This mendelian randomization study used a genetic risk score for birth weight that was constructed with 7 genome-wide significant single-nucleotide polymorphisms. The associations of this score with birth weight and T2D were tested in a mendelian randomization analysis using study-level data. The association of birth weight with T2D was tested using both study-level data (7 single-nucleotide polymorphisms were used as an instrumental variable) and summary-level data from the consortia (43 single-nucleotide polymorphisms were used as an instrumental variable). Data from 180 056 participants from 49 studies were included. Main Outcomes and Measures: Type 2 diabetes and glycemic traits. Results: This mendelian randomization analysis included 49 studies with 41 155 patients with T2D and 80 008 control participants from study-level data and 34 840 patients with T2D and 114 981 control participants from summary-level data. Study-level data showed that a 1-SD decrease in birth weight due to the genetic risk score was associated with higher risk of T2D among all participants (odds ratio [OR], 2.10; 95% CI, 1.69-2.61; P = 4.03 × 10-5), among European participants (OR, 1.96; 95% CI, 1.42-2.71; P = .04), and among East Asian participants (OR, 1.39; 95% CI, 1.18-1.62; P = .04). Similar results were observed from summary-level analyses. In addition, each 1-SD lower birth weight was associated with 0.189 SD higher fasting glucose concentration (β = 0.189; SE = 0.060; P = .002), but not with fasting insulin, 2-hour glucose, or hemoglobin A1c concentration. Conclusions and Relevance: In this study, a genetic predisposition to lower birth weight was associated with increased risk of T2D and higher fasting glucose concentration, suggesting genetic effects on retarded fetal growth and increased diabetes risk that either are independent of each other or operate through alterations of integrated biological mechanisms.
    Àrees temàtiques: Medicine, general & internal Medicine (miscellaneous) Medicine (all) General medicine
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 25743805
    Adreça de correu electrònic de l'autor: joaquin.escribano@urv.cat
    Identificador de l'autor: 0000-0002-5041-459X
    Data d'alta del registre: 2025-02-18
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Jama Network Open. 2 (9): e1910915-
    Referència de l'ítem segons les normes APA: Huang, Tao; Wang, Tiange; Zheng, Yan; Ellervik, Christina; Gao, Meng; Fang, Zhe; Chai, Jin-Fang; Ahluwalia, Tarun Veer S; Wang, Yujie; Voortman, Trudy (2019). Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study. Jama Network Open, 2(9), e1910915-. DOI: 10.1001/jamanetworkopen.2019.10915
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2019
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Medicine (Miscellaneous),Medicine, General & Internal
    Thrifty phenotype
    Risk
    Loci
    Instruments
    Heterogeneity
    Genotype
    Genome-wide association
    Consumption
    Common variants
    Bias
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
    General medicine
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