Autor segons l'article: Gimeno, Aleix; Beltran-Debon, Raul; Mulero, Miguel; Pujadas, Gerard; Garcia-Vallve, Santiago
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Beltrán Debón, Raúl Alejandro / Garcia Vallve, Santiago / Gimeno Vives, Aleix / Mulero Abellán, Miguel / Pujadas Anguiano, Gerard
Paraules clau: Amino acid sequence; Animals; Binding sites; Biological evaluation; Cancer; Chelating inhibitors; Crystal-structures; Design; Fragment-based discovery; Highly potent; Humans; Inflammatory-bowel-disease; Matrix metalloproteinase inhibitors; Matrix metalloproteinases; Mmp inhibition; Zinc-binding group
Resum: Matrix metalloproteinases (MMPs) are a family of proteins involved in a range of pathologies. Given that MMP broad-spectrum inhibition is associated with severe adverse effects, selectivity has become a priority in the design of MMP inhibitors, and is often achieved by targeting the variable S1' pocket. However, the specific characteristics of the S1' pocket that determine inhibitor selectivity are often not described and, in many cases, challenging to identify. In this review, we investigate the variability of the S1' pocket across the MMP family, and propose explanations for the selectivity of previously described inhibitors. These analyses provide valuable insights into how to design novel inhibitors selective for a given MMP.Copyright © 2019 Elsevier Ltd. All rights reserved.
Àrees temàtiques: Astronomia / física; Biochemistry & molecular biology; Biotecnología; Ciências biológicas i; Ciências biológicas ii; Ciências biológicas iii; Drug discovery; Interdisciplinar; Medicina i; Medicina ii; Medicina veterinaria; Pharmacology; Pharmacology & pharmacy; Química
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: raul.beltran@urv.cat; gerard.pujadas@urv.cat; santi.garcia-vallve@urv.cat; miquel.mulero@urv.cat; aleix.gimeno@urv.cat; aleix.gimeno@urv.cat
ISSN: 13596446
Data d'alta del registre: 2025-03-22
Versió de l'article dipositat: info:eu-repo/semantics/submittedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S1359644619303411?via%3Dihub
Referència a l'article segons font original: Drug Discovery Today. 25 (1): 38-57
Referència de l'ítem segons les normes APA: Gimeno, Aleix; Beltran-Debon, Raul; Mulero, Miguel; Pujadas, Gerard; Garcia-Vallve, Santiago (2020). Understanding the variability of the S1' pocket to improve matrix metalloproteinase inhibitor selectivity profiles. Drug Discovery Today, 25(1), 38-57. DOI: 10.1016/j.drudis.2019.07.013
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1016/j.drudis.2019.07.013
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2020
Tipus de publicació: Journal Publications
Repositori URV