Autor segons l'article: Ceausu A, Rodríguez-Gallego E, Peraire J, López-Dupla M, Domingo P, Viladés C, Vidal-Gonzalez J, Peraire M, Perpiñán C, Pacheco YM, Veloso S, Alba V, Vargas M, Castellano AJ, Ruiz-Mateos E, Mallolas J, Vidal F, Rull A
Departament: Medicina i Cirurgia
Autor/s de la URV: Ceausu, Andra / López Dupla, Jesús Miguel / Peraire Forner, José Joaquin / Perpiñan Auguet, Carles / Rodríguez Gallego, Esther / RULL AIXA, ANNA / SIRVENT CALVERA, JUAN JOSÉ / Veloso Esteban, Sergio / Vidal Marsal, Francisco / Vidal, Fernando / Vilades Laborda, Consuelo Gloria
Paraules clau: T-cell recovery Risk Recombinant human interleukin-7 Receptor-alpha Receiving antiretroviral therapy Polymorphisms Low cd4 counts Il-7 Hiv-infected patients Cd4+t-cell recovery
Resum: A relationship between polymorphisms in genes encoding interleukin 7 (IL-7) and its cellular receptor (IL-7R) and antiretroviral therapy (ART)-associated immune recovery in HIV subjects has been previously reported. However, details of this relationship remain unclear, and the association of these polymorphisms with circulating IL-7/IL-7R levels is scarce. Here, we explored whether IL-7/IL-7R axis was associated with quantitative CD4+ T-cell recovery in HIV-infected subjects. IL-7/IL-7R polymorphisms were assessed by genotyping, and multiple inheritance models were used to estimate both, their association with low pre-ART CD4+ T-cell counts and incomplete immune recovery status after 48 weeks of suppressive ART. Integrated data from genetic variants association and soluble plasma IL-7/IL-7R quantification suggest that IL-7/IL-7R genotype expression could alter the homeostatic balance between soluble and membrane-bound receptors. The haplotype analyses indicates that allele combinations impacts pre-ART circulating CD4+ T-cell counts, immune recovery status and the absolute increment of CD4+ T-cell counts. The knowledge about how IL-7/IL-7R axis is related to quantitative CD4+ T-cell recovery and immune recovery status after initiating ART could be useful regarding T-cell reservoirs investigations in HIV subjects.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20452322
Adreça de correu electrònic de l'autor: fernando.vidal@urv.cat carles.perpinan@urv.cat andra.ceausu@urv.cat sergio.veloso@urv.cat joaquim.peraire@urv.cat consuelo.vilades@urv.cat jesusmiguel.lopez@urv.cat francesc.vidal@urv.cat esther.rodriguez@urv.cat carles.perpinan@urv.cat
Identificador de l'autor: 0000-0002-2956-8607 0000-0001-7808-5479 0000-0002-2991-9593 0000-0002-9141-2523 0000-0002-6692-6186
Data d'alta del registre: 2024-06-15
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.nature.com/articles/s41598-019-52025-8
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Scientific Reports. 9 (1): 15722-
Referència de l'ítem segons les normes APA: Ceausu A, Rodríguez-Gallego E, Peraire J, López-Dupla M, Domingo P, Viladés C, Vidal-Gonzalez J, Peraire M, Perpiñán C, Pacheco YM, Veloso S, Alba V, (2019). IL-7/IL-7R gene variants impact circulating IL-7/IL-7R homeostasis and ART-associated immune recovery status. Scientific Reports, 9(1), 15722-. DOI: 10.1038/s41598-019-52025-8
DOI de l'article: 10.1038/s41598-019-52025-8
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Tipus de publicació: Journal Publications
Repositori URV