Articles producció científica> Medicina i Cirurgia

The prognostic value of muscle regional oxygen saturation index in severe community-acquired pneumonia: a prospective observational study

  • Dades identificatives

    Identificador: imarina:6016182
    Autors:
    Claverias, LauraMari, MichaelMarin-Corral, JudithMagret, MonicaTrefler, SandraBodi, MariaGarcia-Espana, AntonioCarlos Yebenes, JuanPascual, SergiGea, JoaquimRodriguez, Alejandro
    Resum:
    Background: Community-acquired pneumonia (CAP) mortality exceeds 20 % in critical care patients despite appropriate antibiotic therapy. Regional tissue oxygen saturation index (rSO2) measured with near-infrared spectroscopy (NIRS) might facilitate early detection for patients at risk of serious complications. Our objectives were to determine the relationship between early determination of rSO2 and mortality and to compare discrimination power for mortality of rSO2 and other resuscitation variables in critically ill CAP patients. Methods: This is a prospective observational study. Patients with CAP were enrolled within 6 h to intensive care admission. Demographics and clinical variables were recorded. rSO2 was determined using NIRS in brachioradialis muscle. All variables were determined at baseline and 24 h after admission. Results: Forty patients were enrolled. Fourteen patients (35 %) had a baseline rSO2 < 60 % and 7 of them died (50 %). Only 1 of 26 (3.8 %) patients with rSO2 >= 60 % died (p = 0.007). The area under ROC curve (AUROC) showed consistent mortality discrimination at baseline (0.84, p = 0.03) and at 24 h (0.86, p = 0.006) for rSO2 values. Cox regression analysis showed that low rSO2 at ICU admission (hazard ratio (HR) = 8.99; 95 % confidence interval (CI) 1.05-76.8; p = 0.045) and low rSO2 at 24 h (HR = 13.18; 95 % CI 1.52-113.6; p = 0.019) were variables independently associated with mortality. In contrast, other variables such as Acute Physiology and Chronic Health Evaluation (APACHE II) score (HR = 1.09; 95 % CI 0.99-1.19; p = 0.052) were not associated with mortality. Conclusions: Our findings suggest that forearm skeletal muscle rSO2 differs in patients with severe CAP according to outcome and might be an early prognosis tool.
  • Altres:

    Autor segons l'article: Claverias, Laura; Mari, Michael; Marin-Corral, Judith; Magret, Monica; Trefler, Sandra; Bodi, Maria; Garcia-Espana, Antonio; Carlos Yebenes, Juan; Pascual, Sergi; Gea, Joaquim; Rodriguez, Alejandro;
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Bodi Saera, Maria Amparo / Magret Iglesias, Mònica / Rodríguez Oviedo, Alejandro Hugo
    Paraules clau: Tissue oxygenation Therapy Systemic cytokine levels Severe sepsis Septic shock Sepsis Neumonía comunitaria grave Near-infrared spectroscopy Mortality Microcirculation Microcirculación Intensive-care-unit Impact Community-acquired pneumonia
    Resum: Background: Community-acquired pneumonia (CAP) mortality exceeds 20 % in critical care patients despite appropriate antibiotic therapy. Regional tissue oxygen saturation index (rSO2) measured with near-infrared spectroscopy (NIRS) might facilitate early detection for patients at risk of serious complications. Our objectives were to determine the relationship between early determination of rSO2 and mortality and to compare discrimination power for mortality of rSO2 and other resuscitation variables in critically ill CAP patients. Methods: This is a prospective observational study. Patients with CAP were enrolled within 6 h to intensive care admission. Demographics and clinical variables were recorded. rSO2 was determined using NIRS in brachioradialis muscle. All variables were determined at baseline and 24 h after admission. Results: Forty patients were enrolled. Fourteen patients (35 %) had a baseline rSO2 < 60 % and 7 of them died (50 %). Only 1 of 26 (3.8 %) patients with rSO2 >= 60 % died (p = 0.007). The area under ROC curve (AUROC) showed consistent mortality discrimination at baseline (0.84, p = 0.03) and at 24 h (0.86, p = 0.006) for rSO2 values. Cox regression analysis showed that low rSO2 at ICU admission (hazard ratio (HR) = 8.99; 95 % confidence interval (CI) 1.05-76.8; p = 0.045) and low rSO2 at 24 h (HR = 13.18; 95 % CI 1.52-113.6; p = 0.019) were variables independently associated with mortality. In contrast, other variables such as Acute Physiology and Chronic Health Evaluation (APACHE II) score (HR = 1.09; 95 % CI 0.99-1.19; p = 0.052) were not associated with mortality. Conclusions: Our findings suggest that forearm skeletal muscle rSO2 differs in patients with severe CAP according to outcome and might be an early prognosis tool.
    Àrees temàtiques: Critical care medicine Critical care and intensive care medicine
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20520492
    Adreça de correu electrònic de l'autor: alejandrohugo.rodriguez@urv.cat monica.magret@urv.cat mariaamparo.bodi@urv.cat mariaamparo.bodi@urv.cat
    Identificador de l'autor: 0000-0001-8828-5984 0000-0002-9534-9920 0000-0001-7652-8379 0000-0001-7652-8379
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://jintensivecare.biomedcentral.com/articles/10.1186/s40560-016-0129-4
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Journal Of Intensive Care. 4 (7): 7-
    Referència de l'ítem segons les normes APA: Claverias, Laura; Mari, Michael; Marin-Corral, Judith; Magret, Monica; Trefler, Sandra; Bodi, Maria; Garcia-Espana, Antonio; Carlos Yebenes, Juan; Pas (2016). The prognostic value of muscle regional oxygen saturation index in severe community-acquired pneumonia: a prospective observational study. Journal Of Intensive Care, 4(7), 7-. DOI: 10.1186/s40560-016-0129-4
    DOI de l'article: 10.1186/s40560-016-0129-4
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2016
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Critical Care and Intensive Care Medicine,Critical Care Medicine
    Tissue oxygenation
    Therapy
    Systemic cytokine levels
    Severe sepsis
    Septic shock
    Sepsis
    Neumonía comunitaria grave
    Near-infrared spectroscopy
    Mortality
    Microcirculation
    Microcirculación
    Intensive-care-unit
    Impact
    Community-acquired pneumonia
    Critical care medicine
    Critical care and intensive care medicine
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