Autor segons l'article: Leal-Witt, M J; Ramon-Krauel, M; Samino, S; Llobet, M; Cuadras, D; Jimenez-Chillaron, J C; Yanes, O; Lerin, C
Departament: Enginyeria Electrònica, Elèctrica i Automàtica
Autor/s de la URV: SAMINO GENÉ, SARA / Yanes Torrado, Óscar
Paraules clau: Sphingolipids Risk-factors Resistance Pediatric obesity Overweight Metabolomics Metabolome Metabolism Male Life style Insulin sensitivity Inhibition Humans Hemoglobin a1c protein, human Glycated hemoglobin a Glycated hemoglobin Female Fatty-acid Exercise Diet Childhood obesity Child
Resum: OBJECTIVE: Childhood obesity is a strong risk factor for adult obesity and metabolic diseases, including type 2 diabetes and cardiovascular disease. Early lifestyle intervention in children with obesity reduces future disease risk. The objective of this study is to identify metabolic signatures associated with lifestyle intervention in prepubertal children with obesity.
METHODS: Thirty-five prepubertal children (7-10 years) with obesity (body mass index (BMI)>42 standard deviations) were enrolled in the study and participated in a 6-month-long lifestyle intervention program. Physiological and biochemical data and blood samples were collected both at baseline and after the intervention. A liquid chromatography-mass spectrometry (LC-MS)-based metabolomics approach was applied to obtain a comprehensive profiling of plasma samples, identifying 2581 distinct metabolite. Principal component analysis (PCA) was performed to consolidate all features into 8 principal components. Associations between metabolites and physiological and biochemical variables were investigated.
RESULTS: The intervention program significantly decreased mean (95% CI) BMI standard deviation score from 3.56 (3.29-3.84) to 3.11 (2.88-3.34) (P < 0.001). PCA identified one component (PC1) significantly altered by the intervention (Bonferroni adjusted P = 0.008). A sphingolipid metabolism-related signature was identified as the major contributor to PC1. Sphingolipid metabolites were decreased by the intervention, and included multiple sphingomyelin, ceramide, glycosylsphingosine and sulfatide species. Changes in several sphingolipid metabolites were associated with intervention-induced improvements in HbA1c levels.
CONCLUSIONS: Decreased circulating sphingolipid-related metabolites were associated with lifestyle intervention in prepubertal children with obesity, and correlated to improvements in HbA1c.
Àrees temàtiques: Serviço social Saúde coletiva Psicología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 03070565
Adreça de correu electrònic de l'autor: oscar.yanes@urv.cat
Identificador de l'autor: 0000-0003-3695-7157
Data d'alta del registre: 2025-02-19
Versió de l'article dipositat: info:eu-repo/semantics/submittedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Obesity. 42 (1): 72-78
Referència de l'ítem segons les normes APA: Leal-Witt, M J; Ramon-Krauel, M; Samino, S; Llobet, M; Cuadras, D; Jimenez-Chillaron, J C; Yanes, O; Lerin, C (2018). Untargeted metabolomics identifies a plasma sphingolipid-related signature associated with lifestyle intervention in prepubertal children with obesity. International Journal Of Obesity, 42(1), 72-78. DOI: 10.1038/ijo.2017.201
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2018
Tipus de publicació: Journal Publications
Repositori URV