Articles producció científica> Medicina i Cirurgia

Precipitated sdLDL: An easy method to estimate LDL particle size

  • Dades identificatives

    Identificador: imarina:6184573
    Autors:
    Fernandez-Cidon, BarbaraCandas-Estebanez, BeatrizRibalta, JosepRock, EdmondGuardiola-Guionnet, MontserratAmigo, NuriaPadro-Miquel, AriadnaAlia-Ramos, PedroPinto-Sala, Xavier
    Resum:
    Background LDL-C lowering is the main measure in cardiovascular disease prevention but a residual risk of ischemic events still remains. Alterations of lipoproteins, specially, increase in small dense LDL (sdLDL) particles are related to this risk. Objective To investigate the potential use of sdLDL cholesterol concentration (sdLDL-C) isolated by an easy precipitation method and to assess the impact of a set of clinical and biochemical variables determined by NMR on sdLDL concentration. Methods sdLDL-C and NMR lipid profile were performed in 85 men samples. Association among them was evaluated using Pearson coefficients (r(xy)). A multivariate regression was performed to identify the influence of NMR variables on sdLDL-C. Results A strong association between sdLDL-C and LDLLDL-P (r(xy) = 0.687) and with LDL-Z (r(xy) = -0.603) was found. The multivariate regression explained a 56.8% in sdLDL-C variation (P = 8.77.10-12). BMI, ApoB, triglycerides, FFA, and LDL-Z showed a significant contribution. The most important ones were ApoB and LDL-Z; a 1nm increase (LDL-Z) leads to decrease 126 nmol/L in sdLDL-C. Conclusion The association between sdLDL-C, LDL-Z, and LDL-P is clear. From a large number of variables, especially LDL-Z and apoB influence on sdLDL-C. Results show that the smaller the LDL size, the higher their cholesterol concentration. Therefore, sdLDL-C determination by using this easy method would be useful to risk stratification and to uncover cardiovascular residual risk.
  • Altres:

    Autor segons l'article: Fernandez-Cidon, Barbara; Candas-Estebanez, Beatriz; Ribalta, Josep; Rock, Edmond; Guardiola-Guionnet, Montserrat; Amigo, Nuria; Padro-Miquel, Ariadna; Alia-Ramos, Pedro; Pinto-Sala, Xavier;
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Guardiola Guionnet, Montserrat / Ribalta Vives, Josep
    Paraules clau: Subclinical atherosclerosis Small dense ldl Risk Residual cardiovascular risk Prevention Prevalence Nuclear magnetic resonance lipid profile Lipoprotein precipitation Incident cardiovascular-disease Density-lipoprotein-cholesterol Coronary-heart-disease Carotid atherosclerosis Atherosclerosis Association Adults residual cardiovascular risk nuclear magnetic resonance lipid profile lipoprotein precipitation atherosclerosis
    Resum: Background LDL-C lowering is the main measure in cardiovascular disease prevention but a residual risk of ischemic events still remains. Alterations of lipoproteins, specially, increase in small dense LDL (sdLDL) particles are related to this risk. Objective To investigate the potential use of sdLDL cholesterol concentration (sdLDL-C) isolated by an easy precipitation method and to assess the impact of a set of clinical and biochemical variables determined by NMR on sdLDL concentration. Methods sdLDL-C and NMR lipid profile were performed in 85 men samples. Association among them was evaluated using Pearson coefficients (r(xy)). A multivariate regression was performed to identify the influence of NMR variables on sdLDL-C. Results A strong association between sdLDL-C and LDLLDL-P (r(xy) = 0.687) and with LDL-Z (r(xy) = -0.603) was found. The multivariate regression explained a 56.8% in sdLDL-C variation (P = 8.77.10-12). BMI, ApoB, triglycerides, FFA, and LDL-Z showed a significant contribution. The most important ones were ApoB and LDL-Z; a 1nm increase (LDL-Z) leads to decrease 126 nmol/L in sdLDL-C. Conclusion The association between sdLDL-C, LDL-Z, and LDL-P is clear. From a large number of variables, especially LDL-Z and apoB influence on sdLDL-C. Results show that the smaller the LDL size, the higher their cholesterol concentration. Therefore, sdLDL-C determination by using this easy method would be useful to risk stratification and to uncover cardiovascular residual risk.
    Àrees temàtiques: Saúde coletiva Química Public health, environmental and occupational health Planejamento urbano e regional / demografia Microbiology (medical) Medicina veterinaria Medicina iii Medicina ii Medicina i Medical laboratory technology Materiais Interdisciplinar Immunology and allergy Hematology Farmacia Engenharias iv Enfermagem Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência da computação Biotecnología Biodiversidade Biochemistry (medical) Astronomia / física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 08878013
    Adreça de correu electrònic de l'autor: josep.ribalta@urv.cat montse.guardiola@urv.cat
    Identificador de l'autor: 0000-0002-8879-4719 0000-0002-9696-7384
    Data d'alta del registre: 2023-02-19
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://onlinelibrary.wiley.com/doi/full/10.1002/jcla.23282
    Referència a l'article segons font original: Journal Of Clinical Laboratory Analysis. 34 (e23282): e23282-
    Referència de l'ítem segons les normes APA: Fernandez-Cidon, Barbara; Candas-Estebanez, Beatriz; Ribalta, Josep; Rock, Edmond; Guardiola-Guionnet, Montserrat; Amigo, Nuria; Padro-Miquel, Ariadna (2020). Precipitated sdLDL: An easy method to estimate LDL particle size. Journal Of Clinical Laboratory Analysis, 34(e23282), e23282-. DOI: 10.1002/jcla.23282
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1002/jcla.23282
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Biochemistry (Medical),Clinical Biochemistry,Hematology,Immunology and Allergy,Medical Laboratory Technology,Microbiology (Medical),Public Health, Environmental and Occupational Health
    Subclinical atherosclerosis
    Small dense ldl
    Risk
    Residual cardiovascular risk
    Prevention
    Prevalence
    Nuclear magnetic resonance lipid profile
    Lipoprotein precipitation
    Incident cardiovascular-disease
    Density-lipoprotein-cholesterol
    Coronary-heart-disease
    Carotid atherosclerosis
    Atherosclerosis
    Association
    Adults
    residual cardiovascular risk
    nuclear magnetic resonance lipid profile
    lipoprotein precipitation
    atherosclerosis
    Saúde coletiva
    Química
    Public health, environmental and occupational health
    Planejamento urbano e regional / demografia
    Microbiology (medical)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Medical laboratory technology
    Materiais
    Interdisciplinar
    Immunology and allergy
    Hematology
    Farmacia
    Engenharias iv
    Enfermagem
    Clinical biochemistry
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência da computação
    Biotecnología
    Biodiversidade
    Biochemistry (medical)
    Astronomia / física
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