Autor segons l'article: García-Heredia A; Marsillach J; Rull A; Triguero I; Fort I; MacKness B; MacKness M; Shih D; Joven J; Camps J
Departament: Medicina i Cirurgia
Autor/s de la URV: Camps Andreu, Jorge / Joven Maried, Jorge / RULL AIXA, ANNA
Resum: We studied the influence of PON1 on metabolic alterations induced by oxidized LDL when incubated with endothelial cells. HUVEC cells were incubated with native LDL, oxidized LDL, oxidized LDL plus HDL from wild type mice, and oxidized LDL plus HDL from PON1-deficient mice. Results showed alterations in carbohydrate and phospholipid metabolism and increased apoptosis in cells incubated with oxidized LDL. These changes were partially prevented by wild type mouse HDL, but the effects were less effective with HDL from PON1-deficient mice. Our results suggest that PON1 may play a significant role in endothelial cell survival by protecting cells from alterations in the respiratory chain induced by oxidized LDL. These results extend current knowledge on the protective role of HDL and PON1 against oxidation and apoptosis in endothelial cells. © 2013 Anabel García-Heredia et al.
Àrees temàtiques: Saúde coletiva Química Psicología Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Immunology Farmacia Engenharias iv Engenharias iii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Antropologia / arqueologia
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 09629351
Adreça de correu electrònic de l'autor: jorge.camps@urv.cat jorge.joven@urv.cat
Identificador de l'autor: 0000-0002-3165-3640 0000-0003-2749-4541
Data d'alta del registre: 2023-02-19
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.hindawi.com/journals/mi/2013/156053/
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Mediators Of Inflammation. 2013 156053-
Referència de l'ítem segons les normes APA: García-Heredia A; Marsillach J; Rull A; Triguero I; Fort I; MacKness B; MacKness M; Shih D; Joven J; Camps J (2013). Paraoxonase-1 inhibits oxidized low-density lipoprotein-induced metabolic alterations and apoptosis in endothelial cells: A nondirected metabolomic study. Mediators Of Inflammation, 2013(), 156053-. DOI: 10.1155/2013/156053
DOI de l'article: 10.1155/2013/156053
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2013
Tipus de publicació: Journal Publications
Repositori URV