Autor segons l'article: Rull, Anna; Hernandez-Aguilera, Anna; Fibla, Montserrat; Sepulveda, Julio; Rodriguez-Gallego, Esther; Riera-Borrull, Marta; Sirvent, Juan J; Martin-Paredero, Vicente; Menendez, Javier A; Camps, Jordi; Joven, Jorge
Departament: Medicina i Cirurgia
Autor/s de la URV: Camps Andreu, Jorge / Fibla Simó, Montserrat / Joven Maried, Jorge / Martín Paredero, Vicente / Rodríguez Gallego, Esther / RULL AIXA, ANNA / SIRVENT CALVERA, JUAN JOSÉ
Paraules clau: atherosclerosis; biological markers; cytokines; genetics; metabolism; peripheral artery disease; Aged; Aged, 80 and over; Atherosclerosis; Atherosclerosis, biological markers, cytokines, genetics, metabolism, peripheral artery disease, risk factors; Atherosclerosis; biomarker; collagen; extracellular matrix; neoepitopes; peripheral artery disease; versican; Biological markers; Biomarkers; Ccl2 protein, human; Chemokine ccl2; Chronic disease; Cytokines; Female; Genetic variation; Genetics; Genotype; Humans; Ischemia; Lower extremity; Male; Metabolism; Middle aged; Monocytes; Peripheral arterial disease; Peripheral artery disease; Polymorphism, single nucleotide; Risk factors
Resum: © The Author(s) 2014. The role of chemokine (C-C motif) ligand 2 (CCL2) in peripheral artery disease is unclear. We measured the difference between serum and plasma levels of CCL2 in patients with chronic ischemia threatening the lower extremities following the observation that atypical chemokine receptors in blood and tissue cells may prevent CCL2 from entering the circulation and consequently modulate its function of attracting monocytes to the site of lesion. To identify the influence of CCL2, we compared the patients' values to those in bio-banked samples from a control population. Further, we explored the association with the Asp42Gly polymorphism (rs12075) in Duffy antigen chemokine receptor; one of these atypical chemokine receptors. When possible, we evaluated in surgically excised normal and affected arteries the calcium burden as well as the expression of CCL2 and related receptors reflecting the inflammatory status. Our findings indicate that circulating CCL2 was significantly associated with the severity and presence of the disease (OR 0.966, 95% CI 0.944 to 0.988, p = 0.003). Circulating CCL2 was dependent on the rs12075 genotype (AA>AG>GG), which, probably, indicates a higher expression of chemokine receptor in the arteries of AA subjects. The associations with genetic variants and the over-expression of atypical chemokine receptors in diseased arteries may have potential implications and our data indicate that CCL2 may represent a previously unrecognized factor that needs to be considered in the screening of patients with risk factors for peripheral artery disease.
Àrees temàtiques: Cardiology and cardiovascular medicine; Ciências biológicas ii; Educação física; General medicine; Medicina i; Medicina ii; Medicina iii; Medicine (miscellaneous); Odontología; Peripheral vascular disease; Saúde coletiva
Adreça de correu electrònic de l'autor: esther.rodriguez@urv.cat; jorge.joven@urv.cat; jorge.camps@urv.cat; montserrat.fibla@urv.cat
ISSN: 1358863X
Data d'alta del registre: 2024-09-28
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://journals.sagepub.com/doi/10.1177/1358863X14554034
Referència a l'article segons font original: Vascular Medicine. 19 (6): 442-451
Referència de l'ítem segons les normes APA: Rull, Anna; Hernandez-Aguilera, Anna; Fibla, Montserrat; Sepulveda, Julio; Rodriguez-Gallego, Esther; Riera-Borrull, Marta; Sirvent, Juan J; Martin-Pa (2014). Understanding the role of circulating chemokine (C-C motif) ligand 2 in patients with chronic ischemia threatening the lower extremities. Vascular Medicine, 19(6), 442-451. DOI: 10.1177/1358863X14554034
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1177/1358863X14554034
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2014
Tipus de publicació: Journal Publications
Repositori URV