Autor segons l'article: Peris-Sampedro F; Cabré M; Basaure P; Reverte I; Domingo J; Teresa Colomina M
Departament: Ciències Mèdiques Bàsiques Psicologia
Autor/s de la URV: BASAURE GARCÍA, PÍA ISABEL / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / REVERTÉ SOLER, INGRID
Paraules clau: Triglycerides Phenotype Pesticide Obesity Mice, transgenic Mice, inbred c57bl Male Leptin Insulin resistance Insulin Insecticides Ghrelin Eating Diet Diabetes mellitus Diabetes Cholinesterases Cholesterol Chlorpyrifos Body weight Blood glucose Apolipoprotein e3 Apolipoprotein e Animals obesity leptin ghrelin diabetes apolipoprotein e
Resum: © 2015 Elsevier Inc.. Increasing evidence links the widespread exposure to organophosphate (OP) pesticides to the global epidemics of type 2 diabetes and obesity. Our recent data highlighted gene×environment interactions: mice expressing the human apolipoprotein E3 (apoE3) isoform were more prone to develop obesity than those expressing apoE2 or apoE4 upon dietary challenge with chlorpyrifos (CPF), the most used OP worldwide. Thus, we aimed to further explore the contribution of the APOE3 genotype on the emergence of obesity and related metabolic dysfunctions upon subchronic exposure to CPF. Seven-month-old targeted replacement apoE3 and C57BL/6N male mice were orally exposed to CPF at 0 or 2. mg/kg body weight/day for 8 consecutive weeks. We examined body weight status, food and water intake, lipid and glucose homeostasis, metabolic biomarkers concentrations, insulin levels and insulin resistance, and leptin and ghrelin profiles. CPF exposure generally increased food ingestion, glucose and total cholesterol concentrations, and tended to elevate acyl ghrelin levels. Nonetheless, excess weight gain and increased leptin levels were inherent to apoE3 mice. Moreover, the propensity towards a diabetic profile was markedly higher in these animals than in C57BL/6N, as they showed a higher homeostatic model assessment for insulin resistance index and higher insulin levels. Although both genotypes were metabolically affected by CPF, the results of the present investigation revealed that apoE3 mice were the most vulnerable to developing obesity and related disturbances following CPF administration through the diet. Since the APOE3 genotype is the most prevalent worldwide, current findings have particular implications for human health.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00139351
Adreça de correu electrònic de l'autor: maria.cabre@urv.cat joseluis.domingo@urv.cat mariateresa.colomina@urv.cat
Identificador de l'autor: 0000-0003-4124-8603 0000-0001-6647-9470 0000-0002-5619-4874
Data d'alta del registre: 2024-10-12
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S0013935115300086?via%3Dihub
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Environmental Research. 142 169-176
Referència de l'ítem segons les normes APA: Peris-Sampedro F; Cabré M; Basaure P; Reverte I; Domingo J; Teresa Colomina M (2015). Adulthood dietary exposure to a common pesticide leads to an obese-like phenotype and a diabetic profile in apoE3 mice. Environmental Research, 142(), 169-176. DOI: 10.1016/j.envres.2015.06.036
DOI de l'article: 10.1016/j.envres.2015.06.036
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2015
Tipus de publicació: Journal Publications