Autor segons l'article: Margalef, Maria; Pons, Zara; Iglesias-Carres, Lisard; Isabel Bravo, Francisca; Muguerza, Begona; Arola-Arnal, Anna
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Arola Arnal, Anna / BRAVO LARA, FERNANDO / Bravo Vázquez, Francisca Isabel / MARGALEF JORNET, MARIA / Muguerza Marquínez, Maria Begoña / PONS VILA, ZARA
Paraules clau: bioavailability; flavonoid-type polyphenols; metabolites; obesity; rats; Adipose tissue; Animals; Bioavailability; Blood-pressure; Brain; Cocoa powder; Flavonoid-type polyphenols; Gene-expression; Grape seed extract; Hepg2 cells; High-fat diet; Liver; Male; Metabolites; Obesity; Polyphenols; Proanthocyanidin extract; Rats; Rats, wistar; Seeds; Spontaneously hypertensive-rats; Tissue distribution; Vitis
Resum: © 2015 American Chemical Society. After ingestion flavanols are metabolized by phase-II enzymes and the microbiota and are distributed throughout the body depending on several factors. Herein we aim to evaluate whether flavanols are tissue-accumulated after the long-term administration of a grape seed polyphenol extract (GSPE) in rats and to study if compounds present in tissues differ in a cafeteria-diet obesity state. For that, plasma, liver, mesenteric white adipose tissue (MWAT), brain, and aorta flavanol metabolites from standard chow-diet-fed (ST) and cafeteria-diet-fed (CAF) rats were analyzed by high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) 21 h after the last 12-week-daily GSPE (100 mg/kg) dosage. Results showed that long-term GSPE intake did not trigger a flavanol tissue accumulation, indicating a clearance of products at each daily dosage. Therefore, results suggest that polyphenol benefits in a disease state would be due to a daily pulsatile effect. Moreover, obesity induced by diet also influences the metabolism and bioavailability of flavanols in rats.
Àrees temàtiques: Agricultural and biological sciences (all); Agricultural and biological sciences (miscellaneous); Agriculture; Agriculture, multidisciplinary; Astronomia / física; Biodiversidade; Biotecnología; Chemistry (all); Chemistry (miscellaneous); Chemistry, applied; Ciência da computação; Ciência de alimentos; Ciências agrárias i; Ciências ambientais; Ciências biológicas i; Ciências biológicas ii; Ciências biológicas iii; Educação; Engenharias ii; Engenharias iii; Engenharias iv; Ensino; Farmacia; Food science & technology; General agricultural and biological sciences; General chemistry; General medicine; Interdisciplinar; Materiais; Medicina i; Medicina ii; Medicina veterinaria; Nutrição; Odontología; Planejamento urbano e regional / demografia; Química; Saúde coletiva; Zootecnia / recursos pesqueiros
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: begona.muguerza@urv.cat; anna.arola@urv.cat; franciscaisabel.bravo@urv.cat
ISSN: 00218561
Data d'alta del registre: 2024-09-21
Versió de l'article dipositat: info:eu-repo/semantics/submittedVersion
Enllaç font original: https://pubs.acs.org/doi/10.1021/acs.jafc.5b03856
Referència a l'article segons font original: Journal Of Agricultural And Food Chemistry. 63 (45): 9996-10003
Referència de l'ítem segons les normes APA: Margalef, Maria; Pons, Zara; Iglesias-Carres, Lisard; Isabel Bravo, Francisca; Muguerza, Begona; Arola-Arnal, Anna (2015). Lack of Tissue Accumulation of Grape Seed Flavanols after Daily Long-Term Administration in Healthy and Cafeteria-Diet Obese Rats. Journal Of Agricultural And Food Chemistry, 63(45), 9996-10003. DOI: 10.1021/acs.jafc.5b03856
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1021/acs.jafc.5b03856
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2015
Tipus de publicació: Journal Publications
Repositori URV