Articles producció científica> Medicina i Cirurgia

Gut microbiota trajectory in early life may predict development of celiac disease

  • Dades identificatives

    Identificador: imarina:6389365
    Autors:
    Olivares MWalker AWCapilla ABenítez-Páez APalau FParkhill JCastillejo GSanz Y
    Resum:
    © The Author(s). 2018. Background: To investigate whether alterations in the developing intestinal microbiota and immune markers precede celiac disease (CD) onset in infants at familial risk of developing the disease. Methods: A nested case-control study was carried out as part of a larger prospective cohort study, which included healthy full-term newborns (> 200) with at least one first relative with biopsy-verified CD. The present study includes cases of CD (n = 10) and the best-matched controls (n = 10) who did not develop the disease after 5-year follow-up. Fecal microbiota, assessed by high-throughput 16S rRNA gene amplicon sequencing, and immune parameters were profiled at 4 and 6 months of age and related to CD onset. Results: The microbiota of infants who remained healthy showed an increase in bacterial diversity over time, characterized by increases in Firmicutes families, but not those who developed CD. Infants who subsequently developed CD showed a significant reduction in sIgA levels over time, while those who remained healthy showed increases in TNF-α correlated to Bifidobacterium spp. An increased relative abundance of Bifidobacterium longum was associated with control children while increased proportions of Bifidobacterium breve and Enterococcus spp. were associated with CD development. Conclusion: The findings suggest that alterations in the early trajectory of gut microbiota in infants at CD risk could influence the immune maturation process and predispose to CD, although larger population studies are warranted to confirm this hypothesis.
  • Altres:

    Autor segons l'article: Olivares M; Walker AW; Capilla A; Benítez-Páez A; Palau F; Parkhill J; Castillejo G; Sanz Y
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Castillejo De Villasante, Gemma
    Paraules clau: Intestinal microbiology Hla genes Celiac disease hla genes celiac disease
    Resum: © The Author(s). 2018. Background: To investigate whether alterations in the developing intestinal microbiota and immune markers precede celiac disease (CD) onset in infants at familial risk of developing the disease. Methods: A nested case-control study was carried out as part of a larger prospective cohort study, which included healthy full-term newborns (> 200) with at least one first relative with biopsy-verified CD. The present study includes cases of CD (n = 10) and the best-matched controls (n = 10) who did not develop the disease after 5-year follow-up. Fecal microbiota, assessed by high-throughput 16S rRNA gene amplicon sequencing, and immune parameters were profiled at 4 and 6 months of age and related to CD onset. Results: The microbiota of infants who remained healthy showed an increase in bacterial diversity over time, characterized by increases in Firmicutes families, but not those who developed CD. Infants who subsequently developed CD showed a significant reduction in sIgA levels over time, while those who remained healthy showed increases in TNF-α correlated to Bifidobacterium spp. An increased relative abundance of Bifidobacterium longum was associated with control children while increased proportions of Bifidobacterium breve and Enterococcus spp. were associated with CD development. Conclusion: The findings suggest that alterations in the early trajectory of gut microbiota in infants at CD risk could influence the immune maturation process and predispose to CD, although larger population studies are warranted to confirm this hypothesis.
    Àrees temàtiques: Microbiology (medical) Microbiology Medicina i General medicine Ciências biológicas i
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20492618
    Adreça de correu electrònic de l'autor: gemma.castillejo@urv.cat
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-018-0415-6
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Microbiome. 6 (1): 36-
    Referència de l'ítem segons les normes APA: Olivares M; Walker AW; Capilla A; Benítez-Páez A; Palau F; Parkhill J; Castillejo G; Sanz Y (2018). Gut microbiota trajectory in early life may predict development of celiac disease. Microbiome, 6(1), 36-. DOI: 10.1186/s40168-018-0415-6
    DOI de l'article: 10.1186/s40168-018-0415-6
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2018
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Microbiology,Microbiology (Medical)
    Intestinal microbiology
    Hla genes
    Celiac disease
    hla genes
    celiac disease
    Microbiology (medical)
    Microbiology
    Medicina i
    General medicine
    Ciências biológicas i
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