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Reasons Why Combination Therapy Should Be the New Standard of Care to Achieve the LDL-Cholesterol Targets: Lipid-lowering combination therapy

  • Dades identificatives

    Identificador: imarina:6494687
    Autors:
    Masana LIbarretxe DPlana N
    Resum:
    © 2020, The Author(s). Purpose of Review: The aim of this report is to review the scientific evidence supporting that lipid lowering therapy (LLT), beyond statins, reduces cardiovascular risk; therefore, treatment strategies based on lipid-lowering drug combination should be implemented. Recent Findings: A strong scientific body of evidence supports the effect of statins on cardiovascular risk reduction. Recent trials using non-statin LLT, ezetimibe, and PCSK9 inhibitors have provide scientific evidence about their impact on cardiovascular prevention. Current clinical guidelines still recommend using high-intensity statin monotherapy before considering combination therapy. Summary: The causal effect of LDL-C on atherosclerosis is well established. Moreover, new RCT, meta-analysis, and Mendelian randomization data, support that the main determinant of risk reduction is the absolute LDL reduction regardless of LLT. Accordingly, the “high-intensity statin therapy” concept should be substituted by “high-intensity lipid lowering therapy.” Combination therapy must become the standard of care of hypercholesterolemia treatment.
  • Altres:

    Autor segons l'article: Masana L; Ibarretxe D; Plana N
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Ibarretxe Gerediaga, Daiana / Masana Marín, Luis / Plana Gil, Núria
    Paraules clau: Very-low levels Statins Safety Pcsk9 inhibitors Metaanalysis Lipid-lowering combination therapy High-risk Fenofibrate therapy Ezetimibe Evolocumab Efficacy Density-lipoprotein cholesterol Cardiovascular prevention Cardiovascular outcomes Association pcsk9 inhibitors lipid-lowering combination therapy ezetimibe cardiovascular prevention
    Resum: © 2020, The Author(s). Purpose of Review: The aim of this report is to review the scientific evidence supporting that lipid lowering therapy (LLT), beyond statins, reduces cardiovascular risk; therefore, treatment strategies based on lipid-lowering drug combination should be implemented. Recent Findings: A strong scientific body of evidence supports the effect of statins on cardiovascular risk reduction. Recent trials using non-statin LLT, ezetimibe, and PCSK9 inhibitors have provide scientific evidence about their impact on cardiovascular prevention. Current clinical guidelines still recommend using high-intensity statin monotherapy before considering combination therapy. Summary: The causal effect of LDL-C on atherosclerosis is well established. Moreover, new RCT, meta-analysis, and Mendelian randomization data, support that the main determinant of risk reduction is the absolute LDL reduction regardless of LLT. Accordingly, the “high-intensity statin therapy” concept should be substituted by “high-intensity lipid lowering therapy.” Combination therapy must become the standard of care of hypercholesterolemia treatment.
    Àrees temàtiques: Saúde coletiva Medicina ii Medicina i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 15343170
    Adreça de correu electrònic de l'autor: daiana.ibarretxe@urv.cat nuria.plana@urv.cat luis.masana@urv.cat
    Identificador de l'autor: 0000-0002-4231-7618 0000-0002-0789-4954
    Data d'alta del registre: 2023-02-19
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://link.springer.com/article/10.1007/s11886-020-01326-w
    Referència a l'article segons font original: Current Cardiology Reports. 22 (8): 66-
    Referència de l'ítem segons les normes APA: Masana L; Ibarretxe D; Plana N (2020). Reasons Why Combination Therapy Should Be the New Standard of Care to Achieve the LDL-Cholesterol Targets: Lipid-lowering combination therapy. Current Cardiology Reports, 22(8), 66-. DOI: 10.1007/s11886-020-01326-w
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1007/s11886-020-01326-w
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine
    Very-low levels
    Statins
    Safety
    Pcsk9 inhibitors
    Metaanalysis
    Lipid-lowering combination therapy
    High-risk
    Fenofibrate therapy
    Ezetimibe
    Evolocumab
    Efficacy
    Density-lipoprotein cholesterol
    Cardiovascular prevention
    Cardiovascular outcomes
    Association
    pcsk9 inhibitors
    lipid-lowering combination therapy
    ezetimibe
    cardiovascular prevention
    Saúde coletiva
    Medicina ii
    Medicina i
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
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