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Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial

  • Dades identificatives

    Identificador: imarina:831546
    Handle: https://hdl.handle.net/20.500.11797/imarina831546
    Autors:
    Corella, DoloresSorli, Jose VGonzalez, Jose IOrtega, CarolinaFito, MontserratBullo, MonicaMartinez-Gonzalez, Miguel AngelRos, EmilioArs, FernandoLapetra, JoseGomez-Gracia, EnriqueSerra-Majem, LluisRuiz-Gutierrez, ValentinaFiol, MiquelColtell, OscarVinyoles, ErnestPinto, XavierMarti, AmeliaSaiz, CarmenOrdovs, Jose MEstruch, Ramon
    Resum:
    The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G?>?A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related to obesity, its association with other cardiovascular risk factors and disease remains uncertain.We analyzed the association between the FAIM2-rs7138803 polymorphism and obesity, blood pressure and heart rate in 7,161 participants (48.3% with type 2 diabetes) in the PREDIMED study at baseline. We also explored gene-diet interactions with adherence to the Mediterranean diet (MedDiet) and examined the effects of the polymorphism on cardiovascular disease incidence per diabetes status after a median 4.8-year dietary intervention (MedDiet versus control group) follow-up.We replicated the association between the FAIM2-rs7138803 polymorphism and greater obesity risk (OR: 1.08; 95% CI: 1.01-1.16; P?=?0.011; per-A allele). Moreover, we detected novel associations of this polymorphism with higher diastolic blood pressure (DBP) and heart rate at baseline (B?=?1.07; 95% CI: 0.97-1.28 bmp in AA vs G-carriers for the whole population), that remained statistically significant even after adjustment for body mass index (P?=?0.012) and correction for multiple comparisons. This association was greater and statistically significant in type-2 diabetic subjects (B?=?1.44: 95% CI: 0.23-2.56 bmp; P?=?0.010 for AA versus G-carriers). Likewise, these findings were also observed longitudinally over 5-year follow-up. Nevertheless, we found no statistically significant gene-diet interactions with MedDiet for this trait. On analyzing myocardial infarction risk, we detected a nominally significant (P?=?0.041) association in type-2 diabetic subjects (HR: 1.86; 95% CI:1.03-3.37 for AA versus G

  • Altres:

    Autor segons l'article: Corella, Dolores; Sorli, Jose V; Gonzalez, Jose I; Ortega, Carolina; Fito, Montserrat; Bullo, Monica; Martinez-Gonzalez, Miguel Angel; Ros, Emilio; Ars, Fernando; Lapetra, Jose; Gomez-Gracia, Enrique; Serra-Majem, Lluis; Ruiz-Gutierrez, Valentina; Fiol, Miquel; Coltell, Oscar; Vinyoles, Ernest; Pinto, Xavier; Marti, Amelia; Saiz, Carmen; Ordovs, Jose M; Estruch, Ramon
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Bulló Bonet, Mònica
    Paraules clau: Heart rate Faim2 Apoptosis
    Resum: The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G?>?A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related to obesity, its association with other cardiovascular risk factors and disease remains uncertain.We analyzed the association between the FAIM2-rs7138803 polymorphism and obesity, blood pressure and heart rate in 7,161 participants (48.3% with type 2 diabetes) in the PREDIMED study at baseline. We also explored gene-diet interactions with adherence to the Mediterranean diet (MedDiet) and examined the effects of the polymorphism on cardiovascular disease incidence per diabetes status after a median 4.8-year dietary intervention (MedDiet versus control group) follow-up.We replicated the association between the FAIM2-rs7138803 polymorphism and greater obesity risk (OR: 1.08; 95% CI: 1.01-1.16; P?=?0.011; per-A allele). Moreover, we detected novel associations of this polymorphism with higher diastolic blood pressure (DBP) and heart rate at baseline (B?=?1.07; 95% CI: 0.97-1.28 bmp in AA vs G-carriers for the whole population), that remained statistically significant even after adjustment for body mass index (P?=?0.012) and correction for multiple comparisons. This association was greater and statistically significant in type-2 diabetic subjects (B?=?1.44: 95% CI: 0.23-2.56 bmp; P?=?0.010 for AA versus G-carriers). Likewise, these findings were also observed longitudinally over 5-year follow-up. Nevertheless, we found no statistically significant gene-diet interactions with MedDiet for this trait. On analyzing myocardial infarction risk, we detected a nominally significant (P?=?0.041) association in type-2 diabetic subjects (HR: 1.86; 95% CI:1.03-3.37 for AA versus G-carriers), although this association did not remain statistically significant following correction for multiple comparisons.We confirmed the FAIM2-rs7138803 relationship with obesity and identified novel and consistent associations with heart rate in particular in type 2 diabetic subjects. Furthermore, our results suggest a possible association of this polymorphism with higher myocardial infarction risk in type-2 diabetic subjects, although this result needs to be replicated as it could represent a false positive.
    Àrees temàtiques: Saúde coletiva Medicina ii Medicina i Internal medicine Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 14752840
    Adreça de correu electrònic de l'autor: monica.bullo@urv.cat
    Identificador de l'autor: 0000-0002-0218-7046
    Data d'alta del registre: 2024-10-12
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://cardiab.biomedcentral.com/articles/10.1186/1475-2840-13-5
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Cardiovascular Diabetology. 13 (1): 5-NA
    Referència de l'ítem segons les normes APA: Corella, Dolores; Sorli, Jose V; Gonzalez, Jose I; Ortega, Carolina; Fito, Montserrat; Bullo, Monica; Martinez-Gonzalez, Miguel Angel; Ros, Emilio; Ar (2014). Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial. Cardiovascular Diabetology, 13(1), 5-NA. DOI: 10.1186/1475-2840-13-5
    DOI de l'article: 10.1186/1475-2840-13-5
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2014
    Tipus de publicació: Journal Publications

  • Paraules clau:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Internal Medicine
    Heart rate
    Faim2
    Apoptosis
    Saúde coletiva
    Medicina ii
    Medicina i
    Internal medicine
    Interdisciplinar
    Farmacia
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
    Biotecnología

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