Autor segons l'article: Flores-Mateo, Gemma; Elosua, Roberto; Rodriguez-Blanco, Teresa; Basora-Gallisa, Josep; Bullo, Monica; Salas-Salvado, Jordi; Angel Martinez-Gonzalez, Miguel; Estruch, Ramon; Corella, Dolores; Fito, Montserrat; Fiol, Miquel; Aros, Fernando; Gomez-Gracia, Enrique; Subirana, Isaac; Lapetra, Jose; Ruiz-Gutierrez, Valentina; Saez, Guillermo T; Covas, Maria-Isabel
Departament: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
Autor/s de la URV: Basora Gallisa, Josep / Bulló Bonet, Mònica / Díaz López, Andres / Fernández Ballart, Joan Domènech / Salas Salvadó, Jorge
Paraules clau: @infoAeu @residentesaeu @uroweb Etiqueta «#» Hashtag
Resum: Studies of associations between plasma GSH-Px activity and cardiovascular risk factors have been done in humans, and contradictory results have been reported. The aim of our study was to assess the association between the scavenger antioxidant enzyme glutathione peroxidase (GSH-Px) activity in plasma and the presence of novel and classical cardiovascular risk factors in elderly patients.We performed a cross-sectional study with baseline data from a subsample of the PREDIMED (PREvención con DIeta MEDiterránea) study in Spain. Participants were 1,060 asymptomatic subjects at high risk for cardiovascular disease (CVD), aged 55 to 80, selected from 8 primary health care centers (PHCCs). We assessed classical CVD risk factors, plasma oxidized low-density lipoproteins (ox-LDL), and glutathione peroxidase (GSH-Px) using multilevel statistical procedures.Mean GSH-Px value was 612 U/L (SE: 12 U/L), with variation between PHCCs ranging from 549 to 674 U/L (Variance =? 013.5; P<0.001). Between-participants variability within a PHCC accounted for 89% of the total variation. Both glucose and oxidized LDL were positively associated with GSH-Px activity after adjustment for possible confounder variables (P = 0.03 and P = 0.01, respectively).In a population at high cardiovascular risk, a positive linear association was observed between plasma GSH-Px activity and both glucose and ox-LDL levels. The high GSH-Px activity observed when an oxidative stress situation occurred, such as hyperglycemia and lipid oxidative damage, could be interpreted as a healthy defensive response against oxidative injury in our cardiovascular risk population.
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Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 19326203
Adreça de correu electrònic de l'autor: josep.basora@urv.cat andres.diaz@urv.cat monica.bullo@urv.cat josep.basora@urv.cat jordi.salas@urv.cat
Identificador de l'autor: 0000-0002-7500-5629 0000-0002-0218-7046 0000-0003-2700-7459
Data d'alta del registre: 2024-10-12
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105881
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Plos One. 9 (9): e105881-
Referència de l'ítem segons les normes APA: Flores-Mateo, Gemma; Elosua, Roberto; Rodriguez-Blanco, Teresa; Basora-Gallisa, Josep; Bullo, Monica; Salas-Salvado, Jordi; Angel Martinez-Gonzalez, M (2014). Oxidative stress is associated with an increased antioxidant defense in elderly subjects: A multilevel approach. Plos One, 9(9), e105881-. DOI: 10.1371/journal.pone.0105881
DOI de l'article: 10.1371/journal.pone.0105881
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2014
Tipus de publicació: Journal Publications