Articles producció científica> Ciències Mèdiques Bàsiques

Oxidative stress is associated with an increased antioxidant defense in elderly subjects: A multilevel approach

  • Dades identificatives

    Identificador: imarina:831792
    Autors:
    Flores-Mateo, GemmaElosua, RobertoRodriguez-Blanco, TeresaBasora-Gallisa, JosepBullo, MonicaSalas-Salvado, JordiAngel Martinez-Gonzalez, MiguelEstruch, RamonCorella, DoloresFito, MontserratFiol, MiquelAros, FernandoGomez-Gracia, EnriqueSubirana, IsaacLapetra, JoseRuiz-Gutierrez, ValentinaSaez, Guillermo TCovas, Maria-Isabel
    Resum:
    Studies of associations between plasma GSH-Px activity and cardiovascular risk factors have been done in humans, and contradictory results have been reported. The aim of our study was to assess the association between the scavenger antioxidant enzyme glutathione peroxidase (GSH-Px) activity in plasma and the presence of novel and classical cardiovascular risk factors in elderly patients.We performed a cross-sectional study with baseline data from a subsample of the PREDIMED (PREvención con DIeta MEDiterránea) study in Spain. Participants were 1,060 asymptomatic subjects at high risk for cardiovascular disease (CVD), aged 55 to 80, selected from 8 primary health care centers (PHCCs). We assessed classical CVD risk factors, plasma oxidized low-density lipoproteins (ox-LDL), and glutathione peroxidase (GSH-Px) using multilevel statistical procedures.Mean GSH-Px value was 612 U/L (SE: 12 U/L), with variation between PHCCs ranging from 549 to 674 U/L (Variance =? 013.5; P<0.001). Between-participants variability within a PHCC accounted for 89% of the total variation. Both glucose and oxidized LDL were positively associated with GSH-Px activity after adjustment for possible confounder variables (P = 0.03 and P = 0.01, respectively).In a population at high cardiovascular risk, a positive linear association was observed between plasma GSH-Px activity and both glucose and ox-LDL levels. The high GSH-Px activity observed when an oxidative stress situation occurred, such as hyperglycemia and lipid oxidative damage, could be interpreted as a healthy defensive response against oxidative injury in our cardiovascular risk population.
  • Altres:

    Autor segons l'article: Flores-Mateo, Gemma; Elosua, Roberto; Rodriguez-Blanco, Teresa; Basora-Gallisa, Josep; Bullo, Monica; Salas-Salvado, Jordi; Angel Martinez-Gonzalez, Miguel; Estruch, Ramon; Corella, Dolores; Fito, Montserrat; Fiol, Miquel; Aros, Fernando; Gomez-Gracia, Enrique; Subirana, Isaac; Lapetra, Jose; Ruiz-Gutierrez, Valentina; Saez, Guillermo T; Covas, Maria-Isabel
    Departament: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
    Autor/s de la URV: Basora Gallisa, Josep / Bulló Bonet, Mònica / Díaz López, Andres / Fernández Ballart, Joan Domènech / Salas Salvadó, Jorge
    Paraules clau: Good health and well-being
    Resum: Studies of associations between plasma GSH-Px activity and cardiovascular risk factors have been done in humans, and contradictory results have been reported. The aim of our study was to assess the association between the scavenger antioxidant enzyme glutathione peroxidase (GSH-Px) activity in plasma and the presence of novel and classical cardiovascular risk factors in elderly patients.We performed a cross-sectional study with baseline data from a subsample of the PREDIMED (PREvención con DIeta MEDiterránea) study in Spain. Participants were 1,060 asymptomatic subjects at high risk for cardiovascular disease (CVD), aged 55 to 80, selected from 8 primary health care centers (PHCCs). We assessed classical CVD risk factors, plasma oxidized low-density lipoproteins (ox-LDL), and glutathione peroxidase (GSH-Px) using multilevel statistical procedures.Mean GSH-Px value was 612 U/L (SE: 12 U/L), with variation between PHCCs ranging from 549 to 674 U/L (Variance =? 013.5; P<0.001). Between-participants variability within a PHCC accounted for 89% of the total variation. Both glucose and oxidized LDL were positively associated with GSH-Px activity after adjustment for possible confounder variables (P = 0.03 and P = 0.01, respectively).In a population at high cardiovascular risk, a positive linear association was observed between plasma GSH-Px activity and both glucose and ox-LDL levels. The high GSH-Px activity observed when an oxidative stress situation occurred, such as hyperglycemia and lipid oxidative damage, could be interpreted as a healthy defensive response against oxidative injury in our cardiovascular risk population.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Sociology Sociología Serviço social Saúde coletiva Química Psychology Psicología Planejamento urbano e regional / demografia Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Linguística e literatura Letras / linguística Interdisciplinary research in the social sciences Interdisciplinar Human geography and urban studies History & philosophy of science Historia Geografía Geociências General medicine General biochemistry,genetics and molecular biology General agricultural and biological sciences Farmacia Environmental studies Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Educação Economia Direito Demography Comunicação e informação Ciências sociais aplicadas i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência política e relações internacionais Ciência de alimentos Ciência da computação Biotecnología Biology Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Astronomia / física Arquitetura, urbanismo e design Archaeology Antropologia / arqueologia Anthropology Agricultural and biological sciences (miscellaneous) Administração, ciências contábeis e turismo Administração pública e de empresas, ciências contábeis e turismo
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 19326203
    Adreça de correu electrònic de l'autor: josep.basora@urv.cat andres.diaz@urv.cat monica.bullo@urv.cat josep.basora@urv.cat jordi.salas@urv.cat
    Identificador de l'autor: 0000-0002-7500-5629 0000-0002-0218-7046 0000-0003-2700-7459
    Data d'alta del registre: 2024-11-16
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105881
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Plos One. 9 (9): e105881-e105881
    Referència de l'ítem segons les normes APA: Flores-Mateo, Gemma; Elosua, Roberto; Rodriguez-Blanco, Teresa; Basora-Gallisa, Josep; Bullo, Monica; Salas-Salvado, Jordi; Angel Martinez-Gonzalez, M (2014). Oxidative stress is associated with an increased antioxidant defense in elderly subjects: A multilevel approach. Plos One, 9(9), e105881-e105881. DOI: 10.1371/journal.pone.0105881
    DOI de l'article: 10.1371/journal.pone.0105881
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2014
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Agricultural and Biological Sciences (Miscellaneous),Biochemistry, Genetics and Molecular Biology (Miscellaneous),Biology,Medicine (Miscellaneous),Multidisciplinary,Multidisciplinary Sciences
    Good health and well-being
    Zootecnia / recursos pesqueiros
    Sociology
    Sociología
    Serviço social
    Saúde coletiva
    Química
    Psychology
    Psicología
    Planejamento urbano e regional / demografia
    Odontología
    Nutrição
    Multidisciplinary sciences
    Multidisciplinary
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Linguística e literatura
    Letras / linguística
    Interdisciplinary research in the social sciences
    Interdisciplinar
    Human geography and urban studies
    History & philosophy of science
    Historia
    Geografía
    Geociências
    General medicine
    General biochemistry,genetics and molecular biology
    General agricultural and biological sciences
    Farmacia
    Environmental studies
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Educação
    Economia
    Direito
    Demography
    Comunicação e informação
    Ciências sociais aplicadas i
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência política e relações internacionais
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biology
    Biodiversidade
    Biochemistry, genetics and molecular biology (miscellaneous)
    Astronomia / física
    Arquitetura, urbanismo e design
    Archaeology
    Antropologia / arqueologia
    Anthropology
    Agricultural and biological sciences (miscellaneous)
    Administração, ciências contábeis e turismo
    Administração pública e de empresas, ciências contábeis e turismo
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