Repositori URV

Identificador: imarina:8679851

Handle: https://hdl.handle.net/20.500.11797/imarina8679851

Autors:
Chicote, Javier U.Lopez-Sanchez, MarcosMarques-Bonet, TomasCallizo, JosePerez-Jurado, Luis A.Garcia-Espana, Antonio

Resum:
Background: Duplications of large genomic segments provide genetic diversity in genome evolution. Despite their importance, how these duplications are generated remains uncertain, particularly for distant duplicated genomic segments. Results: Here we provide evidence of the participation of circular DNA intermediates in the single generation of some large human segmental duplications. A specific reversion of sequence order from A-B/C-D to B-A/D-C between duplicated segments and the presence of only microhomologies and short indels at the evolutionary breakpoints suggest a circularization of the donor ancestral locus and an accidental replicative interaction with the acceptor locus. Conclusions: This novel mechanism of random genomic mutation could explain several distant genomic duplications including some of the ones that took place during recent human evolution.