Articles producció científica> Medicina i Cirurgia

Auto-antibodies against type I IFNs in patients with life-threatening COVID-19

  • Dades identificatives

    Identificador: imarina:8681132
    Handle: https://hdl.handle.net/20.500.11797/imarina8681132
    Autors:
    Bastard, PaulRosen, Lindsey BZhang, QianMichailidis, EleftheriosHoffmann, Hans-HeinrichZhang, YuDorgham, KarimPhilippot, QuentinRosain, JeremieBeziat, VivienManry, JeremyShaw, ElanaHaljasmagi, LiisPeterson, PartLorenzo, LazaroBizien, LucyTrouillet-Assant, SophieDobbs, Kerryde Jesus, Adriana AlmeidaBelot, AlexandreKallaste, AnneCatherinot, EmilieTandjaoui-Lambiotte, YacineLe Pen, JeremieKerner, GaspardBigio, BenedettaSeeleuthner, YoannYang, RuiBolze, AlexandreSpaan, Andras NDelmonte, Ottavia MAbers, Michael SAiuti, AlessandroCasari, GiorgioLampasona, VitoPiemonti, LorenzoCiceri, FabioBilguvar, KayaLifton, Richard PVasse, MarcSmadja, David MMigaud, MelanieHadjadj, JeromeTerrier, BenjaminDuffy, DarraghQuintana-Murci, Lluisvan de Beek, DiederikRoussel, LucieVinh, Donald CTangye, Stuart GHaerynck, FilomeenDalmau, DavidMartinez-Picado, JavierBrodin, PetterNussenzweig, Michel CBoisson-Dupuis, StephanieRodriguez-Gallego, CarlosVogt, GuillaumeMogensen, Trine HOler, Andrew JGu, JingwenBurbelo, Peter DCohen, Jeffrey IBiondi, AndreaBettini, Laura RacheleD'Angio, MariellaBonfanti, PaoloRossignol, PatrickMayaux, JulienRieux-Laucat, FredericHusebye, Eystein SFusco, FrancescaUrsini, Matilde ValeriaImberti, LuisaSottini, AlessandraPaghera, SimoneQuiros-Roldan, EugeniaRossi, CamilloCastagnoli, RiccardoMontagna, DanielaLicari, AmeliaMarseglia, Gian LuigiDuval, XavierGhosn, JadeTsang, John SGoldbach-Mansky, RaphaelaKisand, KaiLionakis, Michail SPuel, AnneZhang, Shen-YingHolland, Steven MGorochov, GuyJouanguy, EmmanuelleRice, Charles MCobat, AurelieNotarangelo, Luigi DAbel, LaurentSu, Helen CCasano
    Resum:
    Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-omega (IFN-omega) (13 patients), against the 13 types of IFN-alpha (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for lifethreatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.

  • Altres:

    Autor segons l'article: Bastard, Paul; Rosen, Lindsey B; Zhang, Qian; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Zhang, Yu; Dorgham, Karim; Philippot, Quentin; Rosain, Jeremie; Beziat, Vivien; Manry, Jeremy; Shaw, Elana; Haljasmagi, Liis; Peterson, Part; Lorenzo, Lazaro; Bizien, Lucy; Trouillet-Assant, Sophie; Dobbs, Kerry; de Jesus, Adriana Almeida; Belot, Alexandre; Kallaste, Anne; Catherinot, Emilie; Tandjaoui-Lambiotte, Yacine; Le Pen, Jeremie; Kerner, Gaspard; Bigio, Benedetta; Seeleuthner, Yoann; Yang, Rui; Bolze, Alexandre; Spaan, Andras N; Delmonte, Ottavia M; Abers, Michael S; Aiuti, Alessandro; Casari, Giorgio; Lampasona, Vito; Piemonti, Lorenzo; Ciceri, Fabio; Bilguvar, Kaya; Lifton, Richard P; Vasse, Marc; Smadja, David M; Migaud, Melanie; Hadjadj, Jerome; Terrier, Benjamin; Duffy, Darragh; Quintana-Murci, Lluis; van de Beek, Diederik; Roussel, Lucie; Vinh, Donald C; Tangye, Stuart G; Haerynck, Filomeen; Dalmau, David; Martinez-Picado, Javier; Brodin, Petter; Nussenzweig, Michel C; Boisson-Dupuis, Stephanie; Rodriguez-Gallego, Carlos; Vogt, Guillaume; Mogensen, Trine H; Oler, Andrew J; Gu, Jingwen; Burbelo, Peter D; Cohen, Jeffrey I; Biondi, Andrea; Bettini, Laura Rachele; D'Angio, Mariella; Bonfanti, Paolo; Rossignol, Patrick; Mayaux, Julien; Rieux-Laucat, Frederic; Husebye, Eystein S; Fusco, Francesca; Ursini, Matilde Valeria; Imberti, Luisa; Sottini, Alessandra; Paghera, Simone; Quiros-Roldan, Eugenia; Rossi, Camillo; Castagnoli, Riccardo; Montagna, Daniela; Licari, Amelia; Marseglia, Gian Luigi; Duval, Xavier; Ghosn, Jade; Tsang, John S; Goldbach-Mansky, Raphaela; Kisand, Kai; Lionakis, Michail S; Puel, Anne; Zhang, Shen-Ying; Holland, Steven M; Gorochov, Guy; Jouanguy, Emmanuelle; Rice, Charles M; Cobat, Aurelie; Notarangelo, Luigi D; Abel, Laurent; Su, Helen C; Casanova, Jean-Laurent
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Auguet Quintillà, Maria Teresa
    Paraules clau: Proteins Interferon Gamma Disease Cytokines Chronic mucocutaneous candidiasis Antibodies
    Resum: Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-omega (IFN-omega) (13 patients), against the 13 types of IFN-alpha (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for lifethreatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psychology Psicología Planejamento urbano e regional / demografia Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar History and philosophy of science Geografía Geociências General o multidisciplinar General medicine Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Economia Direito Ciencias sociales Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência política e relações internacionais Biotecnología Biodiversidade Astronomia / física Antropologia / arqueologia Administração pública e de empresas, ciências contábeis e turismo
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: mariateresa.auguet@urv.cat
    Identificador de l'autor: 0000-0003-0396-6428
    Data d'alta del registre: 2024-09-28
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Science. 370 (6515): 423-+
    Referència de l'ítem segons les normes APA: Bastard, Paul; Rosen, Lindsey B; Zhang, Qian; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Zhang, Yu; Dorgham, Karim; Philippot, Quentin; Rosain (2020). Auto-antibodies against type I IFNs in patients with life-threatening COVID-19. Science, 370(6515), 423-+. DOI: 10.1126/science.abd4585
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications

  • Paraules clau:

    History and Philosophy of Science,Multidisciplinary,Multidisciplinary Sciences
    Proteins
    Interferon
    Gamma
    Disease
    Cytokines
    Chronic mucocutaneous candidiasis
    Antibodies
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psychology
    Psicología
    Planejamento urbano e regional / demografia
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    History and philosophy of science
    Geografía
    Geociências
    General o multidisciplinar
    General medicine
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Educação física
    Economia
    Direito
    Ciencias sociales
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência política e relações internacionais
    Biotecnología
    Biodiversidade
    Astronomia / física
    Antropologia / arqueologia
    Administração pública e de empresas, ciências contábeis e turismo

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