Articles producció científica> Medicina i Cirurgia

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

  • Dades identificatives

    Identificador: imarina:8681133
    Autors:
    Zhang, QianBastard, PaulLiu, ZhiyongLe Pen, JeremieMoncada-Velez, MarcelaChen, JieOgishi, MasatoSabli, Ira K DHodeib, StephanieKorol, CeciliaRosain, JeremieBilguvar, KayaYe, JunqiangBolze, AlexandreBigio, BenedettaYang, RuiArias, Andres AugustoZhou, QinhuaZhang, YuOnodi, FannyKorniotis, SarantisKarpf, LeaPhilippot, QuentinChbihi, MarwaBonnet-Madin, LucieDorgham, KarimSmith, NikaiaSchneider, William MRazooky, Brandon SHoffmann, Hans-HeinrichMichailidis, EleftheriosMoens, LeenHan, Ji EunLorenzo, LazaroBizien, LucyMeade, PhilipNeehus, Anna-LenaUgurbil, Aileen CamilleCorneau, AurelienKerner, GaspardZhang, PengRapaport, FranckSeeleuthner, YoannManry, JeremyMasson, CecileSchmitt, YohannSchlueter, AgathaLe Voyer, TomKhan, TaushifLi, JuanFellay, JacquesRoussel, LucieShahrooei, MohammadAlosaimi, Mohammed FMansouri, DavoodAl-Saud, HayaAl-Mulla, FahdAlmourfi, FerasAl-Muhsen, Saleh ZaidAlsohime, FahadAl Turki, SaeedHasanato, Ranavan de Beek, DiederikBiondi, AndreaBettini, Laura RacheleD'Angio, MariellaBonfanti, PaoloImberti, LuisaSottini, AlessandraPaghera, SimoneQuiros-Roldan, EugeniaRossi, CamilloOler, Andrew JTompkins, Miranda FAlba, CamilleVandernoot, IsabelleGoffard, Jean-ChristopheSmits, GuillaumeMigeotte, IsabelleHaerynck, FilomeenSoler-Palacin, PereMartin-Nalda, AndreaColobran, RogerMorange, Pierre-EmmanuelKeles, SevgiColkesen, FatmaOzcelik, TayfunYasar, Kadriye KartSenoglu, SevtapKarabela, Semsi NurRodriguez-Gallego, CarlosNovelli, GiuseppeHraiech, SamiTandjaoui-Lambiotte, YacineDuval, XavierLaouenan, CedricSnow, Andrew LDalgard, Clifton LMilner, Joshua DVinh, Donald CMogensen
    Resum:
    Clinical outcome upon infection with SARS-CoV-2 ranges from silent infection to lethal COVID-19. We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern TLR3- and IRF7-dependent type I interferon (IFN) immunity to influenza virus, in 659 patients with life-threatening COVID-19 pneumonia, relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally define LOF variants in 23 patients (3.5%), aged 17 to 77 years, underlying autosomal recessive or dominant deficiencies. We show that human fibroblasts with mutations affecting this pathway are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection.Copyright © 2020, American Association for the Advancement of Science.
  • Altres:

    Autor segons l'article: Zhang, Qian; Bastard, Paul; Liu, Zhiyong; Le Pen, Jeremie; Moncada-Velez, Marcela; Chen, Jie; Ogishi, Masato; Sabli, Ira K D; Hodeib, Stephanie; Korol, Cecilia; Rosain, Jeremie; Bilguvar, Kaya; Ye, Junqiang; Bolze, Alexandre; Bigio, Benedetta; Yang, Rui; Arias, Andres Augusto; Zhou, Qinhua; Zhang, Yu; Onodi, Fanny; Korniotis, Sarantis; Karpf, Lea; Philippot, Quentin; Chbihi, Marwa; Bonnet-Madin, Lucie; Dorgham, Karim; Smith, Nikaia; Schneider, William M; Razooky, Brandon S; Hoffmann, Hans-Heinrich; Michailidis, Eleftherios; Moens, Leen; Han, Ji Eun; Lorenzo, Lazaro; Bizien, Lucy; Meade, Philip; Neehus, Anna-Lena; Ugurbil, Aileen Camille; Corneau, Aurelien; Kerner, Gaspard; Zhang, Peng; Rapaport, Franck; Seeleuthner, Yoann; Manry, Jeremy; Masson, Cecile; Schmitt, Yohann; Schlueter, Agatha; Le Voyer, Tom; Khan, Taushif; Li, Juan; Fellay, Jacques; Roussel, Lucie; Shahrooei, Mohammad; Alosaimi, Mohammed F; Mansouri, Davood; Al-Saud, Haya; Al-Mulla, Fahd; Almourfi, Feras; Al-Muhsen, Saleh Zaid; Alsohime, Fahad; Al Turki, Saeed; Hasanato, Rana; van de Beek, Diederik; Biondi, Andrea; Bettini, Laura Rachele; D'Angio, Mariella; Bonfanti, Paolo; Imberti, Luisa; Sottini, Alessandra; Paghera, Simone; Quiros-Roldan, Eugenia; Rossi, Camillo; Oler, Andrew J; Tompkins, Miranda F; Alba, Camille; Vandernoot, Isabelle; Goffard, Jean-Christophe; Smits, Guillaume; Migeotte, Isabelle; Haerynck, Filomeen; Soler-Palacin, Pere; Martin-Nalda, Andrea; Colobran, Roger; Morange, Pierre-Emmanuel; Keles, Sevgi; Colkesen, Fatma; Ozcelik, Tayfun; Yasar, Kadriye Kart; Senoglu, Sevtap; Karabela, Semsi Nur; Rodriguez-Gallego, Carlos; Novelli, Giuseppe; Hraiech, Sami; Tandjaoui-Lambiotte, Yacine; Duval, Xavier; Laouenan, Cedric; Snow, Andrew L; Dalgard, Clifton L; Milner, Joshua D; Vinh, Donald C; Mogensen, Trine H; Marr, Nico; Spaan, Andras N; Boisson, Bertrand; Boisson-Dupuis, Stephanie; Bustamante, Jacinta; Puel, Anne; Ciancanelli, Michael J; Meyts, Isabelle; Maniatis, Tom; Soumelis, Vassili; Amara, Ali; Nussenzweig, Michel; Garcia-Sastre, Adolfo; Krammer, Florian; Pujol, Aurora; Duffy, Darragh; Lifton, Richard P; Zhang, Shen-Ying; Gorochov, Guy; Beziat, Vivien; Jouanguy, Emmanuelle; Sancho-Shimizu, Vanessa; Rice, Charles M; Abel, Laurent; Notarangelo, Luigi D; Cobat, Aurelie; Su, Helen C; Casanova, Jean-Laurent
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Auguet Quintillà, Maria Teresa
    Paraules clau: Susceptibility Nf-kappa-b Herpes-simplex encephalitis Deficiency
    Resum: Clinical outcome upon infection with SARS-CoV-2 ranges from silent infection to lethal COVID-19. We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern TLR3- and IRF7-dependent type I interferon (IFN) immunity to influenza virus, in 659 patients with life-threatening COVID-19 pneumonia, relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally define LOF variants in 23 patients (3.5%), aged 17 to 77 years, underlying autosomal recessive or dominant deficiencies. We show that human fibroblasts with mutations affecting this pathway are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection.Copyright © 2020, American Association for the Advancement of Science.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psychology Psicología Planejamento urbano e regional / demografia Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar History and philosophy of science Geografía Geociências General o multidisciplinar General medicine Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Economia Direito Ciencias sociales Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência política e relações internacionais Biotecnología Biodiversidade Astronomia / física Antropologia / arqueologia Administração pública e de empresas, ciências contábeis e turismo
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: mariateresa.auguet@urv.cat
    Identificador de l'autor: 0000-0003-0396-6428
    Data d'alta del registre: 2024-09-28
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://science.sciencemag.org/content/370/6515/eabd4570
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Science. 370 (6515): 422-+
    Referència de l'ítem segons les normes APA: Zhang, Qian; Bastard, Paul; Liu, Zhiyong; Le Pen, Jeremie; Moncada-Velez, Marcela; Chen, Jie; Ogishi, Masato; Sabli, Ira K D; Hodeib, Stephanie; Korol (2020). Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science, 370(6515), 422-+. DOI: 10.1126/science.abd4570
    DOI de l'article: 10.1126/science.abd4570
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    History and Philosophy of Science,Multidisciplinary,Multidisciplinary Sciences
    Susceptibility
    Nf-kappa-b
    Herpes-simplex encephalitis
    Deficiency
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psychology
    Psicología
    Planejamento urbano e regional / demografia
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    History and philosophy of science
    Geografía
    Geociências
    General o multidisciplinar
    General medicine
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Educação física
    Economia
    Direito
    Ciencias sociales
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência política e relações internacionais
    Biotecnología
    Biodiversidade
    Astronomia / física
    Antropologia / arqueologia
    Administração pública e de empresas, ciências contábeis e turismo
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