Autor segons l'article: Carbonell, Raquel; Moreno, Gerard; Martin-Loeches, Ignacio; Gomez-Bertomeu, Frederic; Sarvise, Carolina; Gomez, Josep; Bodi, Maria; Diaz, Emili; Papiol, Elisabeth; Trefler, Sandra; Nieto, Mercedes; Estella, Angel; Jimenez Herrera, Maria; Vidal Cortes, Pablo; Guardiola, Juan Jose; Sole-Violan, Jordi; Rodriguez, Alejandro;
Departament: Bioquímica i Biotecnologia Medicina i Cirurgia Infermeria
Autor/s de la URV: Bodi Saera, Maria Amparo / Gómez Alvarez, Josep / Gomez Bertomeu, Frederic-Francesc / Jiménez Herrera, María Francisca / Rodríguez Oviedo, Alejandro Hugo / TREFLER CRESPO, SANDRA INES
Paraules clau: Virus pneumonia Task performance Streptococcus pneumoniae Staphylococcus capitis Staphylococcus aureus Sequential organ failure assessment score Sensitivity and specificity Retrospective study Renal replacement therapy Red blood cell distribution width Receiver operating characteristic Procalcitonin Predictive value Pneumonia Observational study Obesity Mortality Middle aged Male Lung lavage Limit of detection Leukocyte count Legionella pneumophila Intensive care unit Influenza Human Heart failure Gram-positive cocci Gram negative bacilli Enzyme linked immunosorbent assay Critically ill patient Creatinine Continuous renal replacement therapy Cohort analysis C-reactive protein C reactive protein Body mass Biological marker Aspergillus Artificial ventilation Article Apache Adult Acute kidney failure
Resum: Background: Procalcitonin (PCT) and C-Reactive protein (CRP) are well-established sepsis biomarkers. The association of baseline PCT levels and mortality in pneumonia remains unclear, and we still do not know whether biomarkers levels could be related to the causative microorganism (GPC, GNB). The objective of this study is to address these issues. Methods: a retrospective observational cohort study was conducted in 184 Spanish ICUs (2009-2018). Results: 1608 patients with severe influenza pneumonia with PCT and CRP available levels on admission were included, 1186 with primary viral pneumonia (PVP) and 422 with bacterial Co-infection (BC). Those with BC presented higher PCT levels (4.25 [0.6-19.5] versus 0.6 [0.2-2.3]ng/mL) and CRP (36.7 [20.23-118] versus 28.05 [13.3-109]mg/dL) as compared to PVP (p < 0.001). Deceased patients had higher PCT (ng/mL) when compared with survivors, in PVP (0.82 [0.3-2.8]) versus 0.53 [0.19-2.1], p = 0.001) and BC (6.9 [0.93-28.5] versus 3.8 [0.5-17.37], p = 0.039). However, no significant association with mortality was observed in the multivariate analysis. The PCT levels (ng/mL) were significantly higher in polymicrobial infection (8.4) and GPC (6.9) when compared with GNB (1.2) and Aspergillus (1.7). The AUC-ROC of PCT for GPC was 0.67 and 0.32 for GNB. The AUROC of CRP was 0.56 for GPC and 0.39 for GNB. Conclusions: a single PCT/CRP value at ICU admission was not associated with mortality in severe influenza pneumonia. None of the biomarkers have enough discriminatory power to be used for predicting the causative microorganism of the co-infection.
Àrees temàtiques: Pharmacology, toxicology and pharmaceutics (miscellaneous) Pharmacology, toxicology and pharmaceutics (all) Pharmacology (medical) Pharmacology & pharmacy Microbiology (medical) Microbiology Infectious diseases General pharmacology, toxicology and pharmaceutics Engenharias ii Biochemistry
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: josep.gomez@urv.cat alejandrohugo.rodriguez@urv.cat frederic-francesc.gomez@urv.cat maria.jimenez@urv.cat mariaamparo.bodi@urv.cat mariaamparo.bodi@urv.cat
Identificador de l'autor: 0000-0002-0573-7621 0000-0001-8828-5984 0000-0002-8039-2889 0000-0003-2599-3742 0000-0001-7652-8379 0000-0001-7652-8379
Data d'alta del registre: 2024-07-27
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Antibiotics. 10 (4):
Referència de l'ítem segons les normes APA: Carbonell, Raquel; Moreno, Gerard; Martin-Loeches, Ignacio; Gomez-Bertomeu, Frederic; Sarvise, Carolina; Gomez, Josep; Bodi, Maria; Diaz, Emili; Papio (2021). Prognostic Value of Procalcitonin and C-Reactive Protein in 1608 Critically Ill Patients with Severe Influenza Pneumonia. Antibiotics, 10(4), -. DOI: 10.3390/antibiotics10040350
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV