Articles producció científica> Medicina i Cirurgia

Predictors of Ascending Aorta Enlargement and Valvular Dysfunction Progression in Patients with Bicuspid Aortic Valve

  • Dades identificatives

    Identificador: imarina:9241177
    Autors:
    Lopez, ADentamaro, IGalian, LCalvo, FAlegret, JMSanchez, VCitro, RMoreo, AChirillo, FColonna, PCarrero, MCBossone, EMoral, SSao-Aviles, AGutierrez, LTeixido-Tura, GRodriguez-Palomares, JEvangelista, A
    Resum:
    Bicuspid aortic valve (BAV) patients are at high risk of developing progressive aortic valve dysfunction and ascending aorta dilation. However, the progression of the disease is not well defined. We aimed to assess mid-long-term aorta dilation and valve dysfunction progression and their predictors. Patients were referred from cardiac outpatient clinics to the echocardiographic laboratories of 10 tertiary hospitals and followed clinically and by echocardiography for > 5 years. Seven hundred and eighteen patients with BAV (median age 47.8 years [IQR 33-62], 69.2% male) were recruited. BAV without raphe was observed in 11.3%. After a median follow-up of 7.2 years [IQR5-8], mean aortic root growth rate was 0.23 & PLUSMN; 0.15 mm/year. On multivariate analysis, rapid aortic root dilation (> 0.35 mm/year) was associated with male sex, hypertension, presence of raphe and aortic regurgitation. Annual ascending aorta growth rate was 0.43 & PLUSMN; 0.32 mm/year. Rapid ascending aorta dilation was related only to hypertension. Variables associated with aortic stenosis and regurgitation progression, adjusted by follow-up time, were presence of raphe, hypertension and dyslipidemia and basal valvular dysfunction, respectively. Intrinsic BAV characteristics and cardiovascular risk factors were associated with aorta dilation and valvular dysfunction progression, taking into account the inherent limitations of our study-design. Strict and early control of cardiovascular risk factors is mandatory in BAV patients.
  • Altres:

    Autor segons l'article: Lopez, A; Dentamaro, I; Galian, L; Calvo, F; Alegret, JM; Sanchez, V; Citro, R; Moreo, A; Chirillo, F; Colonna, P; Carrero, MC; Bossone, E; Moral, S; Sao-Aviles, A; Gutierrez, L; Teixido-Tura, G; Rodriguez-Palomares, J; Evangelista, A
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Alegret Colomé, Josep Maria
    Paraules clau: Stenosis Recommendations History European association Echocardiographic-assessment Dilatation Bicuspid aortic valve Aortic stenosis Aortic regurgitation Aneurysm
    Resum: Bicuspid aortic valve (BAV) patients are at high risk of developing progressive aortic valve dysfunction and ascending aorta dilation. However, the progression of the disease is not well defined. We aimed to assess mid-long-term aorta dilation and valve dysfunction progression and their predictors. Patients were referred from cardiac outpatient clinics to the echocardiographic laboratories of 10 tertiary hospitals and followed clinically and by echocardiography for > 5 years. Seven hundred and eighteen patients with BAV (median age 47.8 years [IQR 33-62], 69.2% male) were recruited. BAV without raphe was observed in 11.3%. After a median follow-up of 7.2 years [IQR5-8], mean aortic root growth rate was 0.23 & PLUSMN; 0.15 mm/year. On multivariate analysis, rapid aortic root dilation (> 0.35 mm/year) was associated with male sex, hypertension, presence of raphe and aortic regurgitation. Annual ascending aorta growth rate was 0.43 & PLUSMN; 0.32 mm/year. Rapid ascending aorta dilation was related only to hypertension. Variables associated with aortic stenosis and regurgitation progression, adjusted by follow-up time, were presence of raphe, hypertension and dyslipidemia and basal valvular dysfunction, respectively. Intrinsic BAV characteristics and cardiovascular risk factors were associated with aorta dilation and valvular dysfunction progression, taking into account the inherent limitations of our study-design. Strict and early control of cardiovascular risk factors is mandatory in BAV patients.
    Àrees temàtiques: Medicine, general & internal Medicine (miscellaneous) Medicine (all)
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: josepmaria.alegret@urv.cat
    Identificador de l'autor: 0000-0002-6117-5512
    Data d'alta del registre: 2024-07-27
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/2077-0383/10/22/5264
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Journal Of Clinical Medicine. 10 (22):
    Referència de l'ítem segons les normes APA: Lopez, A; Dentamaro, I; Galian, L; Calvo, F; Alegret, JM; Sanchez, V; Citro, R; Moreo, A; Chirillo, F; Colonna, P; Carrero, MC; Bossone, E; Moral, S; (2021). Predictors of Ascending Aorta Enlargement and Valvular Dysfunction Progression in Patients with Bicuspid Aortic Valve. Journal Of Clinical Medicine, 10(22), -. DOI: 10.3390/jcm10225264
    DOI de l'article: 10.3390/jcm10225264
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2021
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Medicine (Miscellaneous),Medicine, General & Internal
    Stenosis
    Recommendations
    History
    European association
    Echocardiographic-assessment
    Dilatation
    Bicuspid aortic valve
    Aortic stenosis
    Aortic regurgitation
    Aneurysm
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
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