Articles producció científica> Medicina i Cirurgia

Effect of milk protein content in Toddler formula on later BMI and obesity risk: protocol of the multicentre randomised controlled Toddler Milk Intervention (ToMI) trial

  • Dades identificatives

    Identificador: imarina:9241814
    Autors:
    Grote, VeitJaeger, VanessaEscribano, JoaquinZaragoza, MartaGispert, MarionaGrathwohl, DominikKoletzko, Berthold
    Resum:
    Introduction Reduction of milk protein content in infant formula provided during the first year of life has been shown to reduce early weight gain and obesity later in life. While rapid weight gain during the first 2 years of life is one of the strongest early predictors of obesity, the role of animal protein intake beyond the first year of life is unclear. The aim of this study is to examine the role of milk protein during the second year of life in healthy children on weight gain and obesity risk in preschool age.Methods and analysis This randomised, double-blinded study enrolled 1618 children aged 11.5-13.5 months in Spain and Germany into two groups receiving isocaloric toddler milk with differing protein content during the second year of life. The experimental formula contains 1.5g/100 kcal and the control formula 6.15 g/100 kcal protein and otherwise equal formula composition, except for modified fat content to achieve equal energy density. The primary endpoint is body mass index (BMI)-for-age z-score at the age of 24 months adjusted for BMI at 12 months of age. The children are followed until 6 years of age.Ethics and dissemination Ethics approval was obtained from the ethical committees of the LMU University Hospital Munich, Germany (Nr. 555-15) and at Institut d'Investigacio Sanitaria Pere Virgili, Reus, Spain (Ref. CEIm IISPV 013/2016). We aim at publishing results in peer-reviewed journals and sharing of results with study participants.
  • Altres:

    Autor segons l'article: Grote, Veit; Jaeger, Vanessa; Escribano, Joaquin; Zaragoza, Marta; Gispert, Mariona; Grathwohl, Dominik; Koletzko, Berthold;
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Escribano Subías, Joaquín / Gispert Llauradó, Mariona / Zaragoza Jordana, Marta
    Paraules clau: Weight Waist circumference Vitamin blood level Urea blood level Urea Total body fat Toddler Systolic blood pressure Spain Somatomedin c Somatomedin binding protein 3 Somatomedin binding protein 2 Skinfold thickness Serum albumin Risk factor Risk assessment Randomized controlled trial Protein intake Protein content Prophylaxis Porphyria Physical activity Percentage Paediatrics Other metabolic Obesity Nutritional regulation Nutrition & dietetics Multicenter study Milk protein Male Major clinical study Lipid fingerprinting Lipid composition Leptin Intervention study Insulin Infant formula Infant Human Hip circumference Head circumference Growth Ghrelin Germany Follow up Ferritin blood level Ferritin Female Fat mass Fat content E.g. iron Double blind procedure Dna methylation Diastolic blood pressure Creatinine urine level Creatinine blood level Creatinine Cow milk Controlled study Cohort analysis Children Childhood Child nutrition Child growth Child development Child Caloric intake Calcium urine level Calcium C peptide Body-mass index Body weight gain Body mass Body fat distribution Blood pressure Blood cell count Artificial milk Article Arm circumference Amino acid blood level Amino acid Albumin blood level Age Adiponectin 25 hydroxyvitamin d
    Resum: Introduction Reduction of milk protein content in infant formula provided during the first year of life has been shown to reduce early weight gain and obesity later in life. While rapid weight gain during the first 2 years of life is one of the strongest early predictors of obesity, the role of animal protein intake beyond the first year of life is unclear. The aim of this study is to examine the role of milk protein during the second year of life in healthy children on weight gain and obesity risk in preschool age.Methods and analysis This randomised, double-blinded study enrolled 1618 children aged 11.5-13.5 months in Spain and Germany into two groups receiving isocaloric toddler milk with differing protein content during the second year of life. The experimental formula contains 1.5g/100 kcal and the control formula 6.15 g/100 kcal protein and otherwise equal formula composition, except for modified fat content to achieve equal energy density. The primary endpoint is body mass index (BMI)-for-age z-score at the age of 24 months adjusted for BMI at 12 months of age. The children are followed until 6 years of age.Ethics and dissemination Ethics approval was obtained from the ethical committees of the LMU University Hospital Munich, Germany (Nr. 555-15) and at Institut d'Investigacio Sanitaria Pere Virgili, Reus, Spain (Ref. CEIm IISPV 013/2016). We aim at publishing results in peer-reviewed journals and sharing of results with study participants.
    Àrees temàtiques: Saúde coletiva Psicología Odontología Nutrição Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência da computação Biotecnología
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 2020-048290
    Adreça de correu electrònic de l'autor: mariona.gispert@urv.cat marta.zaragoza@urv.cat joaquin.escribano@urv.cat
    Identificador de l'autor: 0000-0002-5041-459X
    Data d'alta del registre: 2024-07-27
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://bmjopen.bmj.com/content/11/12/e048290.long
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Bmj Open. 11 (12):
    Referència de l'ítem segons les normes APA: Grote, Veit; Jaeger, Vanessa; Escribano, Joaquin; Zaragoza, Marta; Gispert, Mariona; Grathwohl, Dominik; Koletzko, Berthold; (2021). Effect of milk protein content in Toddler formula on later BMI and obesity risk: protocol of the multicentre randomised controlled Toddler Milk Intervention (ToMI) trial. Bmj Open, 11(12), -. DOI: 10.1136/bmjopen-2020-048290
    DOI de l'article: 10.1136/bmjopen-2020-048290
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2021
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Medicine (Miscellaneous),Medicine, General & Internal
    Weight
    Waist circumference
    Vitamin blood level
    Urea blood level
    Urea
    Total body fat
    Toddler
    Systolic blood pressure
    Spain
    Somatomedin c
    Somatomedin binding protein 3
    Somatomedin binding protein 2
    Skinfold thickness
    Serum albumin
    Risk factor
    Risk assessment
    Randomized controlled trial
    Protein intake
    Protein content
    Prophylaxis
    Porphyria
    Physical activity
    Percentage
    Paediatrics
    Other metabolic
    Obesity
    Nutritional regulation
    Nutrition & dietetics
    Multicenter study
    Milk protein
    Male
    Major clinical study
    Lipid fingerprinting
    Lipid composition
    Leptin
    Intervention study
    Insulin
    Infant formula
    Infant
    Human
    Hip circumference
    Head circumference
    Growth
    Ghrelin
    Germany
    Follow up
    Ferritin blood level
    Ferritin
    Female
    Fat mass
    Fat content
    E.g. iron
    Double blind procedure
    Dna methylation
    Diastolic blood pressure
    Creatinine urine level
    Creatinine blood level
    Creatinine
    Cow milk
    Controlled study
    Cohort analysis
    Children
    Childhood
    Child nutrition
    Child growth
    Child development
    Child
    Caloric intake
    Calcium urine level
    Calcium
    C peptide
    Body-mass index
    Body weight gain
    Body mass
    Body fat distribution
    Blood pressure
    Blood cell count
    Artificial milk
    Article
    Arm circumference
    Amino acid blood level
    Amino acid
    Albumin blood level
    Age
    Adiponectin
    25 hydroxyvitamin d
    Saúde coletiva
    Psicología
    Odontología
    Nutrição
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Ensino
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciência da computação
    Biotecnología
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