Autor segons l'article: Grote, Veit; Jaeger, Vanessa; Escribano, Joaquin; Zaragoza, Marta; Gispert, Mariona; Grathwohl, Dominik; Koletzko, Berthold;
Departament: Medicina i Cirurgia
Autor/s de la URV: Escribano Subías, Joaquín / Gispert Llauradó, Mariona / Zaragoza Jordana, Marta
Paraules clau: Weight Waist circumference Vitamin blood level Urea blood level Urea Total body fat Toddler Systolic blood pressure Spain Somatomedin c Somatomedin binding protein 3 Somatomedin binding protein 2 Skinfold thickness Serum albumin Risk factor Risk assessment Randomized controlled trial Protein intake Protein content Prophylaxis Porphyria Physical activity Percentage Paediatrics Other metabolic Obesity Nutritional regulation Nutrition & dietetics Multicenter study Milk protein Male Major clinical study Lipid fingerprinting Lipid composition Leptin Intervention study Insulin Infant formula Infant Human Hip circumference Head circumference Growth Ghrelin Germany Follow up Ferritin blood level Ferritin Female Fat mass Fat content E.g. iron Double blind procedure Dna methylation Diastolic blood pressure Creatinine urine level Creatinine blood level Creatinine Cow milk Controlled study Cohort analysis Children Childhood Child nutrition Child growth Child development Child Caloric intake Calcium urine level Calcium C peptide Body-mass index Body weight gain Body mass Body fat distribution Blood pressure Blood cell count Artificial milk Article Arm circumference Amino acid blood level Amino acid Albumin blood level Age Adiponectin 25 hydroxyvitamin d
Resum: Introduction Reduction of milk protein content in infant formula provided during the first year of life has been shown to reduce early weight gain and obesity later in life. While rapid weight gain during the first 2 years of life is one of the strongest early predictors of obesity, the role of animal protein intake beyond the first year of life is unclear. The aim of this study is to examine the role of milk protein during the second year of life in healthy children on weight gain and obesity risk in preschool age.Methods and analysis This randomised, double-blinded study enrolled 1618 children aged 11.5-13.5 months in Spain and Germany into two groups receiving isocaloric toddler milk with differing protein content during the second year of life. The experimental formula contains 1.5g/100 kcal and the control formula 6.15 g/100 kcal protein and otherwise equal formula composition, except for modified fat content to achieve equal energy density. The primary endpoint is body mass index (BMI)-for-age z-score at the age of 24 months adjusted for BMI at 12 months of age. The children are followed until 6 years of age.Ethics and dissemination Ethics approval was obtained from the ethical committees of the LMU University Hospital Munich, Germany (Nr. 555-15) and at Institut d'Investigacio Sanitaria Pere Virgili, Reus, Spain (Ref. CEIm IISPV 013/2016). We aim at publishing results in peer-reviewed journals and sharing of results with study participants.
Àrees temàtiques: Saúde coletiva Psicología Odontología Nutrição Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência da computação Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 2020-048290
Adreça de correu electrònic de l'autor: mariona.gispert@urv.cat marta.zaragoza@urv.cat joaquin.escribano@urv.cat
Identificador de l'autor: 0000-0002-5041-459X
Data d'alta del registre: 2024-07-27
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://bmjopen.bmj.com/content/11/12/e048290.long
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Bmj Open. 11 (12):
Referència de l'ítem segons les normes APA: Grote, Veit; Jaeger, Vanessa; Escribano, Joaquin; Zaragoza, Marta; Gispert, Mariona; Grathwohl, Dominik; Koletzko, Berthold; (2021). Effect of milk protein content in Toddler formula on later BMI and obesity risk: protocol of the multicentre randomised controlled Toddler Milk Intervention (ToMI) trial. Bmj Open, 11(12), -. DOI: 10.1136/bmjopen-2020-048290
DOI de l'article: 10.1136/bmjopen-2020-048290
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications