Early antiretroviral therapy initiation effect on metabolic profile in vertically HIV-1-infected children

Autor segons l'article: Tarancon-Diez, Laura; Rull, Anna; Herrero, Pol; Vazquez-Alejo, Elena; Peraire, Joaquim; Guillen, Sara; Luisa Navarro-Gomez, Maria; Vilades, Consuelo; Angeles Munoz-Fernandez, Ma; Vidal, Francesc

Departament: Bioquímica i Biotecnologia; Medicina i Cirurgia

Autor/s de la URV: HERRERO GIL, POL / Peraire Forner, José Joaquin / RULL AIXA, ANNA / Vidal Marsal, Francisco / Vilades Laborda, Consuelo Gloria

Paraules clau: Proteomics; Metabolome; Humans; Hiv-infected children; Hiv-1; Hiv seropositivity; Hiv infections; Child; Antiretroviral therapy, highly active; time; lysozyme; b-cells; absence

Resum: Background: Early combined antiretroviral treatment (cART) in perinatally acquired HIV-1 children has been associated with a rapid viral suppression, small HIV-1 reservoir size and reduced mortality and morbidity. Immunometabolism has emerged as an important field in HIV-1 infection offering both relevant knowledge regarding immunopathogenesis and potential targets for therapies against HIV-1. Objectives: To characterize the proteomic, lipidomic and metabolomic profile of HIV-1-infected children depending on their age at cART initiation. Patients and methods: Plasma samples from perinatally HIV-1-infected children under suppressive cART who initiated an early cART (first 12 weeks after birth, EARLY, n = 10) and late cART (12-50 weeks after birth, LATE, n = 10) were analysed. Comparative plasma proteomics, lipidomics and metabolomics analyses were performed by nanoLC-Orbitrap, UHPLC-qTOF and GC-qTOF, respectively. Results: Seven of the 188 proteins identified exhibited differences comparing EARLY and LATE groups of HIV-1-infected children. Despite no differences in the lipidomic (n = 115) and metabolomic (n = 81) profiles, strong correlations were found between proteins and lipid levels as well as metabolites, including glucidic components and amino acids, with clinical parameters. The ratio among different proteins showed high discriminatory power of EARLY and LATE groups. Conclusions: Protein signature show a different proinflammatory state associated with a late cART introduction. Its associations with lipid levels and the relationships found between metabolites and clinical parameters may potentially trigger premature non-AIDS events in this HIV-1 population, including atherosclerotic diseases and metabolic disorders. Antiretroviral treatment should be started as soon as possible in perinatally acquired HIV-1-infected children to prevent them from future long-life complications. © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Àrees temàtiques: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Pharmacology (medical); Pharmacology & pharmacy; Pharmacology; Odontología; Nutrição; Microbiology (medical); Microbiology; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Infectious diseases; General medicine; Farmacia; Engenharias iii; Engenharias ii; Enfermagem; Educação física; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciência de alimentos; Biotecnología; Biodiversidade; Astronomia / física

Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/

Adreça de correu electrònic de l'autor: joaquim.peraire@urv.cat; consuelo.vilades@urv.cat; francesc.vidal@urv.cat

Data d'alta del registre: 2025-02-18

Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion

Enllaç font original: https://academic.oup.com/jac/article/76/11/2993/6360037

URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/

Referència a l'article segons font original: Journal Of Antimicrobial Chemotherapy. 76 (11): 2993-3001

Referència de l'ítem segons les normes APA: Tarancon-Diez, Laura; Rull, Anna; Herrero, Pol; Vazquez-Alejo, Elena; Peraire, Joaquim; Guillen, Sara; Luisa Navarro-Gomez, Maria; Vilades, Consuelo; (2021). Early antiretroviral therapy initiation effect on metabolic profile in vertically HIV-1-infected children. Journal Of Antimicrobial Chemotherapy, 76(11), 2993-3001. DOI: 10.1093/jac/dkab277

DOI de l'article: 10.1093/jac/dkab277

Entitat: Universitat Rovira i Virgili

Any de publicació de la revista: 2021

Tipus de publicació: Journal Publications