Articles producció científica> Medicina i Cirurgia

Different protein intake in the first year and its effects on adiposity rebound and obesity throughout childhood: 11 years follow-up of a randomized controlled trial

  • Dades identificatives

    Identificador: imarina:9280224
  • Autors:

    Totzauer, Martina
    Escribano, Joaquin
    Closa-Monasterolo, Ricardo
    Luque, Veronica
    Verduci, Elvira
    ReDionigi, Alice
    Langhendries, Jean-Paul
    Martin, Francoise
    Xhonneux, Annick
    Gruszfeld, Dariusz
    Socha, Piotr
    Grote, Veit
    Koletzko, Berthold
    European Childhood Obesity Trial S
  • Altres:

    Autor segons l'article: Totzauer, Martina; Escribano, Joaquin; Closa-Monasterolo, Ricardo; Luque, Veronica; Verduci, Elvira; ReDionigi, Alice; Langhendries, Jean-Paul; Martin, Francoise; Xhonneux, Annick; Gruszfeld, Dariusz; Socha, Piotr; Grote, Veit; Koletzko, Berthold;European Childhood Obesity Trial S
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Closa Monasterolo, Ricardo / Escribano Subías, Joaquín / Ferre Pallas, Natalia / Luque Moreno, Verònica
    Paraules clau: Weight-gain Risk Protein Pediatric gastroenterology Overweight Obesity Nutrition Infant formula Growth Breastfeeding Body-mass index Bmi trajectory Bmi Age Adiposity rebound
    Resum: Background and Objectives Infant feeding affects child growth and later obesity risk. We examined whether protein supply in infancy affects the adiposity rebound, body mass index (BMI) and overweight and obesity up to 11 years of age. Methods We enrolled healthy term infants from five European countries in a double blind randomized trial, with anticipated 16 examinations within 11 years follow-up. Formula-fed infants (n = 1090) were randomized to isoenergetic formula with higher or lower protein content within the range stipulated by EU legislation in 2001. A breastfed reference group (n = 588) was included. Adiposity rebound and BMI trajectories were estimated by generalized additive mixed models in 917 children, with 712 participating in the 11 year follow-up. Results BMI trajectories were elevated in the higher compared to the lower protein group, with significantly different BMI at adiposity rebound (0.24 kg/m(2), 0.01-0.47, p = 0.040), and an increased risk for overweight at 11 years (adjusted Odds Ratio 1.70; 1.06-2.73; p = 0.027) but no significant difference for obesity (adjusted Odds Ratio 1.47; 0.66-3.27). The two formula groups did not differ in the timing of adiposity rebound, but all children with obesity at 11 years had an early adiposity rebound before four years. Conclusions Compared to conventional high protein formula, feeding lower protein formula in infancy lowers BMI trajectories up to 11 years and achieves similar BMI values at adiposity rebound as observed in breastfed infants.
    Àrees temàtiques: Saúde coletiva Public health, environmental and occupational health Pediatrics, perinatology and child health Pediatrics Nutrition and dietetics Nutrição Medicina ii Medicina i Health policy General medicine Engenharias iv Ciências biológicas i
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: veronica.luque@urv.cat ricardo.closa@urv.cat natalia.ferre@urv.cat joaquin.escribano@urv.cat
    Identificador de l'autor: 0000-0003-2615-8175 0000-0002-9963-4163 0000-0002-2838-1525 0000-0002-5041-459X
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://onlinelibrary.wiley.com/doi/full/10.1111/ijpo.12961
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Pediatric Obesity. 17 (12): e12961-
    Referència de l'ítem segons les normes APA: Totzauer, Martina; Escribano, Joaquin; Closa-Monasterolo, Ricardo; Luque, Veronica; Verduci, Elvira; ReDionigi, Alice; Langhendries, Jean-Paul; Martin (2022). Different protein intake in the first year and its effects on adiposity rebound and obesity throughout childhood: 11 years follow-up of a randomized controlled trial. Pediatric Obesity, 17(12), e12961-. DOI: 10.1111/ijpo.12961
    DOI de l'article: 10.1111/ijpo.12961
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2022
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Health Policy,Nutrition and Dietetics,Pediatrics,Pediatrics, Perinatology and Child Health,Public Health, Environmental and Occupational Health
    Weight-gain
    Risk
    Protein
    Pediatric gastroenterology
    Overweight
    Obesity
    Nutrition
    Infant formula
    Growth
    Breastfeeding
    Body-mass index
    Bmi trajectory
    Bmi
    Age
    Adiposity rebound
    Saúde coletiva
    Public health, environmental and occupational health
    Pediatrics, perinatology and child health
    Pediatrics
    Nutrition and dietetics
    Nutrição
    Medicina ii
    Medicina i
    Health policy
    General medicine
    Engenharias iv
    Ciências biológicas i
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