Autor segons l'article: Bertran, Laia; Portillo-Carrasquer, Marta; Barrientos-Riosalido, Andrea; Aguilar, Carmen; Riesco, David; Martinez, Salome; Culebradas, Amada; Vives, Margarita; Sabench, Fatima; Del Castillo, Daniel; Richart, Cristobal; Auguet, Teresa;
Departament: Medicina i Cirurgia
Autor/s de la URV: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Culebradas Barrera, Amada / Del Castillo Déjardin, Daniel / Martínez González, María Salomé / Martinez Lluis, Sergio / Richart Jurado, Cristobal Manuel / Riesco Acevedo, David Gerardo / Sabench Pereferrer, Fàtima / VIVES GARCIA, MARIA
Paraules clau: Wnt Visceral fat Steatohepatitis Sfrp5 Secreted frizzled-related protein 5 Ppar-gamma Obesity Non-alcoholic fatty liver disease Metabolic dysfunction Insulin-resistance Hepatic steatosis Gene-expression Adipose tissue-liver axis Activated-receptor-gamma
Resum: Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipocytokine secreted by adipocytes that seems to be linked with nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the role of the SFRP5-wingless-MMTV integration site family member 5a (WNT5A) pathway, closely related to adipogenesis, in subcutaneous (SAT) and visceral adipose tissues (VAT) and its relationship with obesity-related NAFLD. Our cohort was composed of 60 women with morbid obesity (MO), who underwent hypocaloric diet, subclassified according to their hepatic histopathology and 15 women with normal weight. We observed increased SFRP5 mRNA expression in VAT and lower WNT5A expression in SAT in MO compared to normal weight. We found elevated SFRP5 expression in nonalcoholic steatohepatitis (NASH) in SAT and in mild simple steatosis (SS) and NASH in VAT. We observed higher WNT5A expression in SS compared to normal liver in SAT, and a peak of WNT5A expression in mild SS. To conclude, we reported increased SFRP5 mRNA expression in SAT and VAT of NAFLD-related to obesity subjects, suggesting an implication of the SFRP5-WNT5A pathway in NAFLD pathogenesis, probably due to the adipose tissue-liver axis. Since the mechanisms by which this potential interaction takes place remain elusive, more research in this field is needed.
Àrees temàtiques: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: davidgerardo.riesco@urv.cat amada.culebradas@urv.cat mariasalome.martinez@urv.cat danieldel.castillo@urv.cat cristobalmanuel.richart@urv.cat sergio.martinezl@urv.cat mariateresa.auguet@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat fatima.sabench@urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat
Identificador de l'autor: 0000-0001-6185-2889 0000-0003-0456-3102 0000-0001-7024-7824 0000-0003-0852-6739 0000-0002-3941-5348 0000-0003-0396-6428 0000-0002-4440-562X 0000-0002-4440-562X 0000-0002-9262-8756 0000-0001-9052-1368 0000-0001-9052-1368
Data d'alta del registre: 2024-03-03
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/1422-0067/23/17/9871
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Molecular Sciences. 23 (17):
Referència de l'ítem segons les normes APA: Bertran, Laia; Portillo-Carrasquer, Marta; Barrientos-Riosalido, Andrea; Aguilar, Carmen; Riesco, David; Martinez, Salome; Culebradas, Amada; Vives, M (2022). Increased Secreted Frizzled-Related Protein 5 mRNA Expression in the Adipose Tissue of Women with Nonalcoholic Fatty Liver Disease Associated with Obesity. International Journal Of Molecular Sciences, 23(17), -. DOI: 10.3390/ijms23179871
DOI de l'article: 10.3390/ijms23179871
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2022
Tipus de publicació: Journal Publications
Repositori URV